gene

PICALM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PICALM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

490Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Gene profile: PICALM — Phosphatidylinositol Binding Clathrin Assembly Protein, key AD risk gene involved in clathrin-mediated endocytosis

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🧬 Gene Info

Gene Symbol	PICALM
Full Name	Phosphatidylinositol Binding Clathrin Assembly Protein
Chromosome	10q24.2
Function	is a gene located on chromosome 10q24.
Primary Expression	Brain, Blood cells, Heart, Lung
Molecular Weight	70 kDa
Amino Acids	652 aa
Exons	21
Pathways	Amyloid, Autophagy, Clathrin-mediated Endocytosis, Complement, Glucose Metabolism
UniProt ID	Q7Z417
NCBI Gene ID	81501
Ensembl ID	ENSG00000021762
OMIM	610004
GeneCards	PICALM
Human Protein Atlas	PICALM
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Cognitive Resilience
Interactions	ABCA1, ABCA7, Actin, AD, AKT, ALZHEIMER
KG Connections	490 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PICALM — AlphaFold Q7Z417 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PICALM["PICALM"]
    PICALM -->|"contributes to"| Alzheimer["Alzheimer"]
    PICALM -.biomarker for.-> Aging["Aging"]
    PICALM -->|"contributes to"| APP["APP"]
    PICALM -->|"implicated in"| neurodegeneration["neurodegeneration"]
    ENDOSOMES["ENDOSOMES"] -->|"contributes to"| PICALM
    ALZHEIMER["ALZHEIMER"] -->|"contributes to"| PICALM
    AMYLOID["AMYLOID"] -->|"contributes to"| PICALM
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"contributes to"| PICALM

Outgoing (230)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PICALM	data_in	dataset_row	0.00
ad_genetic_risk_loci:PICALM	data_in	dataset_row	0.00
ds-db4a006ea647	provides_data_for	dataset	1.00
ds-f50762b67605	provides_data_for	dataset	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Alzheimer's disease	associated_with	disease	0.95
Autophagy	regulates	process	0.90
Clathrin-mediated Endocytosis	regulates	process	0.90
Cognitive Resilience	associated_with	phenotype	0.88
Tau Pathology	modulates	process	0.85
amyloid-beta clearance	regulates	process	0.85
oxidative stress response	participates_in	pathway	0.80
Cognitive Aging	risk_factor_for	phenotype	0.80
Gestational Diabetes	risk_factor_for	disease	0.75
Impaired Glucose Tolerance	protects_against	disease	0.72
PSEN1	expresses	gene	0.70
RELN	protects_against	gene	0.70
RELN	markers	gene	0.70
STING	expresses	gene	0.70
VPS35	associated_with	gene	0.70
TAU	mediates	gene	0.70
TAU	causes	gene	0.70
TAU	markers	gene	0.70
STING	associated_with	gene	0.70
microglia	expressed_in	cell_type	0.70
Glucose Metabolism	involved_in	process	0.70
APOE	associated_with	gene	0.70
endothelial cells	expressed_in	cell_type	0.70
Aging	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Ms	associated_with	disease	0.65
ALS	regulates	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Dementia	associated_with	disease	0.65
Als	regulates	disease	0.65
TAU	interacts_with	gene	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	associated_with	disease	0.65
AMYLOID	regulates	protein	0.65
AMYLOID	causes	protein	0.65
APOPTOSIS	activates	phenotype	0.65
APOPTOSIS	inhibits	phenotype	0.65
MAPK	causes	gene	0.65
ERK	regulates	gene	0.65
Alzheimer	associated_with	disease	0.65
LRP1	interacts_with	gene	0.65

Incoming (260)

Source	Relation	Type	Str
ad_genetic_risk_loci:PICALM	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:PICALM	data_in	dataset_row	0.00
ds-db4a006ea647	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-f50762b67605	data_in	dataset	1.00
ALZHEIMER DISEASE	associated_with	gene	0.80
GENES	associated_with	gene	0.80
NEURONS	interacts_with	cell_type	0.70
CLU	markers	gene	0.70
APOE	markers	gene	0.70
ENDOTHELIAL	regulates	cell_type	0.70
APOE	protects_against	gene	0.70
ENDOTHELIAL	mediates	cell_type	0.70
APP	expressed_in	gene	0.70
MICROGLIA	expresses	cell_type	0.70
MAPT	markers	gene	0.70
LDLR	activates	gene	0.70
ENDOTHELIAL	activates	cell_type	0.70
GSK3B	associated_with	gene	0.70
CLU	associated_with	gene	0.70
SORL1	associated_with	gene	0.70
CR1	associated_with	gene	0.70
MAPK	treats	gene	0.65
ROS	regulates	phenotype	0.65
AND	interacts_with	gene	0.60
MS4A	expressed_in	gene	0.60
ENDOTHELIAL	enhances	cell_type	0.60
MS4A	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AKT	activates	gene	0.60
HLA	expressed_in	gene	0.60
INSULIN SIGNALING	mediates	pathway	0.60
MIRNAS	associated_with	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
DNA	regulates	gene	0.60
HLA-DRB1	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
ERK	activates	gene	0.60
LRP1	enhances	gene	0.60
MAPK	inhibits	gene	0.60
GENETIC LOCI	associated_with	gene	0.60
LRP1	expresses	gene	0.60
APOE	mediates	gene	0.60
MAPK	associated_with	gene	0.60
LRP1	interacts_with	gene	0.60
GENES	regulates	gene	0.60
MAPK	activates	gene	0.60
MTOR	protects_against	gene	0.60
SYNAPSE	regulates	gene	0.60
FTLD	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PICALM in their description or question text

No additional research found