concept

MEMANTINE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEMANTINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

131Connections

0Hypotheses

0Analyses

50Outgoing

49Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MEMANTINE
Key Genes/Proteins	AKT, AMPK, AMYLOID, APP, BDNF, CREB
Related Diseases	ACETYLCHOLINE, ALZHEIMER, ALZHEIMER'S DISEASE, ALZHEIMERS_DISEASE, CHOLESTEROL

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Memantine - NMDA Antagonist for Alzheimer's Disease

therapeutic · 847 words

→

Pathway Diagram

graph TD
    MEMANTINE["MEMANTINE"]
    MEMANTINE -->|"inhibits"| NMDA_RECEPTOR["NMDA RECEPTOR"]
    MEMANTINE -->|"treats"| Dementia["Dementia"]
    MEMANTINE -->|"treats"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    MEMANTINE -->|"treats"| Moderate_To_Severe_Dementia["Moderate To Severe Dementia"]
    MEMANTINE -->|"treats"| Alzheimer_s_Disease["Alzheimer's Disease"]
    MEMANTINE -->|"promotes"| Functional_Stabilization["Functional Stabilization"]
    MEMANTINE -->|"activates"| NRF2["NRF2"]
    MEMANTINE -->|"activates"| NMDA["NMDA"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| MEMANTINE
    DEMENTIA["DEMENTIA"] -->|"inhibits"| MEMANTINE
    CREB["CREB"] -->|"activates"| MEMANTINE
    EXCITOTOXICITY["EXCITOTOXICITY"] -->|"activates"| MEMANTINE
    DONEPEZIL["DONEPEZIL"] -->|"activates"| MEMANTINE
    APP["APP"] -->|"produces"| MEMANTINE

Outgoing (82)

Target	Relation	Type	Str
ad_clinical_trial_failures:memantine	data_in	dataset_row	0.00
ad_clinical_trial_failures:memantine	data_in	dataset_row	0.00
Dementia	treats	disease	0.90
Moderate To Severe Dementia	treats	disease	0.90
Alzheimer'S Disease	treats	disease	0.90
Alzheimer's Disease	treats	disease	0.85
Functional Stabilization	promotes	phenotype	0.85
Nrf2	activates	pathway	0.80
Nrf2 Pathway	activates	pathway	0.80
NMDA receptor	inhibits	receptor	0.80
glutamate signaling	modulates	pathway	0.80
NRF2	activates	protein	0.80
CREB/RCAN1	activates	pathway	0.80
Alzheimer's Disease	treats	disease	0.75
Oxidative Stress	associated_with	process	0.75
NMDA	inhibits	entity	0.70
unfolded protein response	modulates	pathway	0.70
NMDA	activates	entity	0.70
Alzheimer's disease	treats	disease	0.70
NEURONS	protects_against	cell_type	0.65
NEURON	protects_against	cell_type	0.65
TAU	transports	gene	0.65
NEURODEGENERATION	exacerbates	disease	0.65
NEURODEGENERATION	activates	disease	0.65
TAU	phosphorylates	gene	0.65
NMDAR	treats	gene	0.65
NMDAR	regulates	gene	0.65
NMDAR	inhibits	gene	0.65
MICROGLIA	treats	cell_type	0.65
NEURODEGENERATION	regulates	phenotype	0.65
AKT	inhibits	gene	0.65
AKT	regulates	gene	0.65
AKT	treats	gene	0.65
INFLAMMATION	activates	phenotype	0.65
NEURODEGENERATION	inhibits	phenotype	0.65
ALZHEIMERS_DISEASE	treats	disease	0.64
depression	treats	disease	0.60
neuroinflammation	treats	disease	0.60
NMDA	targets	gene	0.60
NMDA receptor	treats	receptor	0.60
CREB	targets	gene	0.60
APP	targets	gene	0.60
NMDAR	targets	gene	0.60
APP	inhibits	gene	0.60
frontotemporal dementia	treats	disease	0.60
Parkinson's disease	treats	disease	0.60
APP	associated_with	gene	0.60
RCAN1	targets	gene	0.60
NMDA receptor	secreted_by	receptor	0.60
NMDA receptor	activates	receptor	0.60

Incoming (49)

Source	Relation	Type	Str
ad_clinical_trial_failures:memantine	data_in	dataset_row	0.00
ad_clinical_trial_failures:memantine	data_in	dataset_row	0.00
ALZHEIMER'S DISEASE	treats	disease	0.65
ALZHEIMER	treats	disease	0.65
RIBOSOME	produces	organelle	0.65
GALANTAMINE	activates	drug	0.65
DONEPEZIL	associated_with	drug	0.65
EMPAGLIFLOZIN	treats	drug	0.65
NEURON	treats	cell_type	0.65
ALZHEIMER	causes	disease	0.65
ALZHEIMER'S DISEASE	regulates	disease	0.65
AKT	phosphorylates	gene	0.65
CHOLINERGIC	promotes	cell_type	0.65
APP	transports	gene	0.65
ACETYLCHOLINE	associated_with	phenotype	0.50
DOPAMINERGIC NEURONS	associated_with	cell_type	0.50
INFLAMMATION	associated_with	phenotype	0.50
CHOLESTEROL	associated_with	phenotype	0.50
NEURODEGENERATION	associated_with	phenotype	0.50
PARKINSON'S DISEASE	associated_with	disease	0.50
NEUROINFLAMMATION	associated_with	phenotype	0.45
COGNITIVE DECLINE	associated_with	phenotype	0.45
TIDEGLUSIB	associated_with	drug	0.45
NRF2 PATHWAY	associated_with	pathway	0.45
PRAMIPEXOLE	associated_with	drug	0.45
DEMENTIA	associated_with	disease	0.45
EXCITOTOXICITY	associated_with	phenotype	0.45
RIVASTIGMINE	associated_with	drug	0.45
GALANTAMINE	associated_with	drug	0.45
TAU PHOSPHORYLATION	associated_with	phenotype	0.45
CREB	associated_with	gene	0.45
MELATONIN	associated_with	drug	0.45
ALZHEIMER	associated_with	disease	0.45
GLUTAMATE	associated_with	phenotype	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
AKT	associated_with	gene	0.45
GLUTAMATE EXCITOTOXICITY	associated_with	phenotype	0.45
EMPAGLIFLOZIN	associated_with	drug	0.45
BARICITINIB	associated_with	drug	0.45
DEMENTIA	inhibits	disease	0.35
CREB	activates	gene	0.35
APP	produces	gene	0.35
APP	inhibits	gene	0.35
APP	therapeutic_target	gene	0.35
ALZHEIMER'S DISEASE	therapeutic_target	disease	0.35
AKT	activates	gene	0.35
ALZHEIMER'S DISEASE	activates	disease	0.35
EXCITOTOXICITY	activates	process	0.35
DONEPEZIL	activates	drug	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MEMANTINE in their description or question text

No additional research found