| Gene Symbol | HSP60 |
| Full Name | HSP60 (Heat Shock 60) |
| Aliases | Hsp60 protein, Heat Shock Protein 60 |
| Protein Type | Protein |
| Function | is a mitochondrial chaperonin protein essential for proper protein folding within the mitochondrion. |
| Primary Expression | testis and some peripheral tissues |
| Molecular Weight | 60.3 kDa |
| Pathways | Apoptosis, Autophagy, Mapk, Mitophagy, Nf-Κb |
| UniProt ID | Search UniProt |
| GeneCards | HSP60 |
| Human Protein Atlas | HSP60 |
| Heptameric ring | Seven Hsp60 subunits arrange in a ring-like structure, each approximately 60 kDa |
| Double-barrel architecture | The complex forms two stacked heptameric rings, creating a barrel-shaped chamber approximately 25 nm in diameter |
| ATP-binding domains | Each subunit contains an ATP-binding pocket in the equatorial domain, required for the conformational changes that drive the folding cycle |
| Flexible apical domains | The apical domains form the entrance to the folding chamber and interact with client proteins and co-chaperones |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | memantine |
| Interactions | AGING, AIFM1, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND |
| KG Connections | 206 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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