concept

DHFR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DHFR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

0Analyses

27Outgoing

8Incoming

0Experiments

0Debates

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💡 Concept Info

Name	DHFR
Key Genes/Proteins	Actin, AND, App, CANCER, FERROPTOSIS, FSP1
Related Diseases	Als, ALS, Cancer
Related Pathways	Complement

Pathway Diagram

graph TD
    DHFR["DHFR"]
    DHFR -.protects against.-> Ferroptosis["Ferroptosis"]
    DHFR -->|"inhibits"| Cancer["Cancer"]
    DHFR -->|"inhibits"| Als["Als"]
    DHFR -->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    DHFR -->|"inhibits"| ALS["ALS"]
    NAD["NAD"] -->|"inhibits"| DHFR
    NQO1["NQO1"] -->|"inhibits"| DHFR
    FSP1["FSP1"] -->|"inhibits"| DHFR
    FERROPTOSIS["FERROPTOSIS"] -->|"inhibits"| DHFR
    NEURODEGENERATION["NEURODEGENERATION"] -->|"inhibits"| DHFR
    AND["AND"] -->|"inhibits"| DHFR
    UBIQUITIN["UBIQUITIN"] -->|"inhibits"| DHFR
    CANCER["CANCER"] -->|"inhibits"| DHFR

Outgoing (27)

Target	Relation	Type	Str
Ferroptosis	protects_against	process	0.85
ALS	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ferroptosis	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
ALS	inhibits	disease	0.65
GR	inhibits	gene	0.60
Actin	interacts_with	protein	0.60
Ras	inhibits	protein	0.60
App	interacts_with	protein	0.60
CANCER	inhibits	gene	0.60
NAD	inhibits	gene	0.60
AND	inhibits	gene	0.60
FSP1	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
NQO1	inhibits	gene	0.60
Rb	inhibits	protein	0.60
App	inhibits	protein	0.60
ferroptosis	inhibits	process	0.60
GFP	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
Complement	interacts_with	pathway	0.60
ferroptosis	participates_in	pathway	0.60
GFP	associated_with	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60

Incoming (8)

Source	Relation	Type	Str
NEURODEGENERATION	inhibits	gene	0.60
AND	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
NAD	inhibits	gene	0.60
NQO1	inhibits	gene	0.60
FSP1	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
CANCER	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DHFR in their description or question text

No additional research found