gene

MS4A6A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MS4A6A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

206Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Membrane Spanning 4-Domains A6A, Alzheimer's disease risk gene involved in microglial signaling

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🧬 Gene Info

Gene Symbol	MS4A6A
Full Name	Membrane Spanning 4-Domains A6A
Chromosome	11q12.2
Function	Membrane Protein Function: MS4A6A operates as a membrane receptor or scavenger receptor involved in cellular homeostasis
Primary Expression	Microglia, B-cells, Myeloid cells
Molecular Weight	28 kDa
Amino Acids	243 aa
Exons	6
UniProt ID	Q9H5Z1
NCBI Gene ID	64231
Ensembl ID	ENSG00000110079
GeneCards	MS4A6A
Human Protein Atlas	MS4A6A
Associated Diseases	Als, Alzheimer, GLIOBLASTOMA
Interactions	ABCA7, AND, APOE, BIN1, CD2AP, CD33
KG Connections	206 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MS4A6A — AlphaFold Q9H5Z1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

MS4A6A Gene

gene · 2260 words

→

MS4A4A-MS4A6A Cooperation in TREM2 Regulation

mechanism · 1807 words

→

MS4A4A/MS4A6A → TREM2 Negative Regulation → Microglial Dysfunction → AD Causal Chain

mechanism · 1022 words

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MS4A6A Protein

protein · 643 words

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Pathway Diagram

graph TD
    MS4A6A["MS4A6A"]
    OPTN["OPTN"]
    MS4A6A -->|"associated with"| OPTN
    PARK7["PARK7"]
    MS4A6A -->|"associated with"| PARK7
    PARKINSON["PARKINSON"]
    MS4A6A -->|"associated with"| PARKINSON
    PINK1["PINK1"]
    MS4A6A -->|"associated with"| PINK1
    PSEN1["PSEN1"]
    MS4A6A -->|"associated with"| PSEN1
    PSEN2["PSEN2"]
    MS4A6A -->|"associated with"| PSEN2
    SNCA["SNCA"]
    MS4A6A -->|"associated with"| SNCA
    SOD1["SOD1"]
    MS4A6A -->|"associated with"| SOD1
    TAU["TAU"]
    MS4A6A -->|"associated with"| TAU
    TBK1["TBK1"]
    MS4A6A -->|"associated with"| TBK1
    TREM2["TREM2"]
    MS4A6A -->|"associated with"| TREM2
    VPS35["VPS35"]
    MS4A6A -->|"associated with"| VPS35
    ABCA7["ABCA7"]
    ABCA7 -->|"associated with"| MS4A6A
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"associated with"| MS4A6A
    ALS["ALS"]
    ALS -->|"associated with"| MS4A6A
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| MS4A6A
    AMYLOID["AMYLOID"]
    AMYLOID -->|"associated with"| MS4A6A
    APOE["APOE"]
    APOE -->|"associated with"| MS4A6A
    APP["APP"]
    APP -->|"associated with"| MS4A6A
    ATP13A2["ATP13A2"]
    ATP13A2 -->|"associated with"| MS4A6A
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"associated with"| MS4A6A
    BIN1["BIN1"]
    BIN1 -->|"associated with"| MS4A6A
    C9ORF72["C9ORF72"]
    C9ORF72 -->|"associated with"| MS4A6A
    CD33["CD33"]
    CD33 -->|"associated with"| MS4A6A
    style MS4A6A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (112)

Target	Relation	Type	Str
ad_genetic_risk_loci:MS4A6A	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:MS4A6A	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-f50762b67605	provides_data_for	dataset	1.00
DAP12	binds	protein	0.90
DAP12	interacts_with	protein	0.80
glioblastoma	activates	disease	0.80
Alzheimer's disease	interacts_with	disease	0.70
glioblastoma	regulates	disease	0.70
Ms	expressed_in	disease	0.65
Als	associated_with	disease	0.65
tau	co_discussed	concept	0.65
ALS	associated_with	disease	0.65
GLIOBLASTOMA	causes	disease	0.65
MICROGLIA	regulates	cell_type	0.65
Glioblastoma	activates	disease	0.65
astrocyte	co_discussed	concept	0.65
amyloid	co_discussed	concept	0.65
MTOR	co_discussed	gene	0.65
AGING	interacts_with	phenotype	0.65
TREM2	co_discussed	gene	0.65
T CELLS	activates	cell_type	0.65
Alzheimer	associated_with	disease	0.65
neuroinflammation	co_discussed	concept	0.65
TREM2	causes	gene	0.65
MICROGLIA	protects_against	cell_type	0.65
ROS	causes	gene	0.60
AND	associated_with	gene	0.60
lipid metabolism	participates_in	pathway	0.60
ROS	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
RNA	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
Alzheimer's disease	regulates	disease	0.60
microglia	expressed_in	cell_type	0.60
MIRNAS	associated_with	gene	0.60
macrophages	expressed_in	cell_type	0.60
App	associated_with	protein	0.60
Microglia	associated_with	cell_type	0.60
ALZHEIMER	associated_with	gene	0.60
CYTOKINES	expressed_in	gene	0.60
Monocyte	associated_with	cell_type	0.60
glioblastoma	interacts_with	disease	0.60
Amyloid	associated_with	pathway	0.60
T cells	expressed_in	cell_type	0.60
glioblastoma	biomarker_for	disease	0.60
Immune Response	associated_with	pathway	0.60
CASS4	associated_with	gene	0.60
glioblastoma	protects_against	disease	0.60
glioblastoma	expressed_in	disease	0.60

Incoming (94)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:MS4A6A	data_in	dataset_row	0.00
ad_genetic_risk_loci:MS4A6A	data_in	dataset_row	0.00
ds-f50762b67605	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
MS4A4A	interacts_with	gene	0.90
GBM	activates	gene	0.80
GBM	regulates	gene	0.70
BDNF	co_discussed	gene	0.65
GBM	expressed_in	gene	0.60
MICROGLIA	co_discussed	gene	0.60
HLA	associated_with	gene	0.60
MS4A	interacts_with	gene	0.60
ERK	inhibits	gene	0.60
MERTK	associated_with	gene	0.60
APOE	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
EPHA1	associated_with	gene	0.60
HLA	regulates	gene	0.60
GBM	protects_against	gene	0.60
GBM	biomarker_for	gene	0.60
CD36	activates	gene	0.60
CD38	activates	gene	0.60
CD4	activates	gene	0.60
CDK4	inhibits	gene	0.60
GBM	interacts_with	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
AND	contributes_to	gene	0.60
GENES	associated_with	gene	0.60
APOE Ε4	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60
AND	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
GBM	associated_with	gene	0.60
CR1	associated_with	gene	0.60
ZCWPW1	interacts_with	gene	0.60
GAB2	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
PTK2B	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
NME8	interacts_with	gene	0.60
ABCA7	interacts_with	gene	0.60
MS4A4E	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
TOMM40	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MS4A6A in their description or question text

No additional research found