protein

CD47

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD47: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

385Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CD47 is a protein involved in neurodegeneration research. Key relationships include: regulates, inhibits, therapeutic target. Associated with ALS, Aging, Als. Connected to 160 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CD47
Chromosome	3q13.1
Function	CD47 is a transmembrane protein that acts as a "don't eat me" signal by binding to SIRPα on macrophages and other phagocytic cells.
Primary Expression	various brain regions and cell types, where it contributes to cellular signaling, gene regulation, and homeostasis
Amino Acids	323 aa
Pathways	Adaptive Immunity, Amyloid, Apoptosis, Complement, Endocytosis
Ensembl ID	ENSG00000196776
GeneCards	CD47
Human Protein Atlas	CD47
Associated Diseases	Aging, Als, Alzheimer, Cancer, Glioblastoma
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ASTROCYTE
KG Connections	385 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD47["CD47"]
    CD47 -->|"regulates"| Inflammation["Inflammation"]
    CD47 -->|"regulates"| Als["Als"]
    CD47 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    CD47 -->|"regulates"| Aging["Aging"]
    CD47 -->|"regulates"| Alzheimer["Alzheimer"]
    CD47 -->|"regulates"| Autism["Autism"]
    CD47 -->|"regulates"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
    CD47 -->|"regulates"| Depression["Depression"]
    CD47 -->|"inhibits"| Ms["Ms"]
    CX3CR1["CX3CR1"] -->|"regulates"| CD47
    C1Q["C1Q"] -->|"regulates"| CD47
    S100A8["S100A8"] -->|"inhibits"| CD47
    OVERVIEW["OVERVIEW"] -->|"regulates"| CD47
    CD68["CD68"] -->|"inhibits"| CD47
    TNF["TNF"] -->|"inhibits"| CD47
    RAGE["RAGE"] -->|"interacts"| CD47
    CD19["CD19"] -->|"target for"| CD47
    MICROGLIA["MICROGLIA"] -->|"target for"| CD47

Outgoing (247)

Target	Relation	Type	Str
Neutrophil Extracellular Traps Formation	inhibits	process	0.95
macrophage phagocytosis	inhibits	process	0.93
neutrophil extracellular traps formation	inhibits	process	0.90
SIRPα	binds	receptor	0.90
S100A8/A9	downregulates	protein	0.85
Phagocytosis	inhibits	process	0.85
Neutrophil Extracellular Traps	inhibits	biological_process	0.80
microglia	expressed_in	cell_type	0.80
neutrophil extracellular traps	interferes_with	process	0.80
Depression	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
complement cascade	participates_in	pathway	0.70
neurons	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
Phagocytosis	therapeutic_target	pathway	0.70
Tumor	regulates	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	interacts_with	disease	0.65
Autism	regulates	disease	0.65
Als	regulates	disease	0.65
Aging	regulates	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	interacts_with	disease	0.65
Infection	regulates	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Spinal Cord Injury	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Retinal Degeneration	regulates	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Glioblastoma	regulates	disease	0.65
Als	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Aging	associated_with	disease	0.65
Parkinson	regulates	disease	0.65
Dementia	regulates	disease	0.65
Cancer	activates	disease	0.65
Inflammation	regulates	disease	0.65
Tumor	activates	disease	0.65
Als	associated_with	disease	0.65

Incoming (138)

Source	Relation	Type	Str
MYC	transcriptionally_regulates	gene	0.92
Lactate	upregulates	compound	0.90
EGFR	promotes	gene	0.90
Histone Lactylation	upregulates	process	0.90
MYC	binds_to	gene	0.88
Galectin-3	associated_with	protein	0.80
DEPRESSION	regulates	gene	0.70
PHAGOCYTOSIS	therapeutic_target	gene	0.70
LACTATE	activates	phenotype	0.65
LACTATE	causes	phenotype	0.65
LACTATE	regulates	phenotype	0.65
CYTOKINES	activates	gene	0.60
AND	associated_with	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
AND	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
GENES	regulates	gene	0.60
STROKE	inhibits	gene	0.60
COMPLEMENT	associated_with	gene	0.60
AND	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AGING	associated_with	gene	0.60
GENES	associated_with	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
AND	protects_against	gene	0.60
APOPTOSIS	regulates	gene	0.60
AND	inhibits	gene	0.60
PER	regulates	gene	0.60
CANCER	associated_with	gene	0.60
AND	therapeutic_target	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
NF-KB	causes	gene	0.60
DNA	therapeutic_target	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
INFLAMMATION	causes	gene	0.60
CANCER	therapeutic_target	gene	0.60
IL-6	inhibits	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
CD36	associated_with	gene	0.60
CD19	therapeutic_target	gene	0.60
GBM	therapeutic_target	gene	0.60
TGM2	causes	gene	0.60
PKC	regulates	gene	0.60
CALCINEURIN	regulates	gene	0.60
SNAP25	regulates	gene	0.60
GEPHYRIN	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Anti-CD47/SIRPα Checkpoint Therapy to Enhance Phagocytic Cle	0.500	immunomics	Systemic immune profiling in neurodegene
Microglial Membrane Camouflage Exploits CD47-SIRPα Checkpoin	0.444	neuroinflammation	How does Alectinib, a kinase inhibitor,

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 44 hypotheses Top: 0.990

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning CD47 in their description or question text

No additional research found