gene

CACNA1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

40Outgoing

26Incoming

0Experiments

0Debates

Summary

CACNA1A is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Ms. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CACNA1A
Full Name	Calcium Voltage-Gated Channel Subunit Alpha1 A
Aliases	Calcium Channel Alpha-1A Subunit
Chromosome	19p13.13
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	cerebellar Purkinje cells and hippocampal neurons, where it mediates:
UniProt ID	O00555
NCBI Gene ID	773
Ensembl ID	ENSG00000141837
OMIM	601011
GeneCards	CACNA1A
Human Protein Atlas	CACNA1A
Associated Diseases	Als, Ms
Known Drugs/Compounds	GW201
Interactions	CACNA1C, CACNA1D, CACNA1E, cacna1f, CACNA1F, CACNA1G
KG Connections	66 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CACNA1A — AlphaFold O00555 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CACNA1A — Calcium Channel Alpha-1A Subunit

gene · 745 words

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CACNA1A Gene

gene · 1605 words

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Pathway Diagram

graph TD
    CACNA1A["CACNA1A"]
    Als{"Als"}
    CACNA1A -->|"associated with"| Als
    Ms{"Ms"}
    CACNA1A -->|"associated with"| Ms
    CHAT["CHAT"]
    CACNA1A -->|"associated with"| CHAT
    FERMT2["FERMT2"]
    CACNA1A -->|"associated with"| FERMT2
    OPTN["OPTN"]
    CACNA1A -->|"associated with"| OPTN
    GENES["GENES"]
    CACNA1A -->|"associated with"| GENES
    ABCA1["ABCA1"]
    CACNA1A -->|"associated with"| ABCA1
    DPM2["DPM2"]
    CACNA1A -->|"associated with"| DPM2
    TBK1["TBK1"]
    CACNA1A -->|"associated with"| TBK1
    neurodegeneration["neurodegeneration"]
    CACNA1A -->|"implicated in"| neurodegeneration
    ATXN2["ATXN2"]
    ATXN2 -->|"associated with"| CACNA1A
    NORMAL_TENSION_GLAUCOMA["NORMAL TENSION GLAUCOMA"]
    NORMAL_TENSION_GLAUCOMA -->|"associated with"| CACNA1A
    CHAT -->|"associated with"| CACNA1A
    ABCA1 -->|"associated with"| CACNA1A
    style CACNA1A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (40)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Als	causes	disease	0.65
Als	associated_with	disease	0.65
SLC1A3	causes	gene	0.60
KCNA1	causes	gene	0.60
FGF14	causes	gene	0.60
Purkinje	causes	cell_type	0.60
GENES	associated_with	gene	0.60
CACNA1E	interacts_with	gene	0.60
CACNA1F	interacts_with	gene	0.60
CACNA1G	interacts_with	gene	0.60
CACNA1H	interacts_with	gene	0.60
CACNA1I	interacts_with	gene	0.60
CACNA2D1	interacts_with	gene	0.60
CACNA2D2	interacts_with	gene	0.60
CACNA1D	interacts_with	gene	0.60
FERMT2	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
ABCA1	associated_with	gene	0.60
DPM2	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA2D2	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CACNA1I	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
SCA3	activates	gene	0.60
CACNA1F	associated_with	gene	0.60
AND	associated_with	gene	0.60
neurons	expressed_in	cell_type	0.60
EPILEPSY	causes	gene	0.60
Neuron	causes	cell_type	0.60
Fibroblast	causes	cell_type	0.60
Fgf	causes	protein	0.60
CACNA1C	interacts_with	gene	0.50

Incoming (26)

Source	Relation	Type	Str
GW201	modulates	compound	0.85
ABCA1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA1I	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA2D2	associated_with	gene	0.60
NORMAL TENSION GLAUCOMA	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
ACO2	regulates	gene	0.60
ATXN2	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
GAIN	contributes_to	gene	0.60
CACNA1F	associated_with	gene	0.60
cacna1f	interacts_with	gene	0.50
CACNA2D2	interacts_with	gene	0.50
CACNA1I	interacts_with	gene	0.50
CACNA2D1	interacts_with	gene	0.50
CACNA1E	interacts_with	protein	0.50
CACNA1H	interacts_with	protein	0.50
CACNA1G	interacts_with	protein	0.50
CACNA1D	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CACNA1A in their description or question text

No additional research found