gene

PLAU

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLAU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

175Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PLAU encodes urokinase-type plasminogen activator, a serine protease involved in fibrinolysis, extracellular matrix remodeling, and neuroinflammation. It plays complex roles in neurodegenerative diseases including Alzheimer's and Parkinson's.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	PLAU
Aliases	uPA, urokinase, ATF
Chromosome	10q22.2
Protein Type	Protease
Function	is a gene encoding a secreted serine protease that plays critical roles in fibrinolysis, extracellular matrix (ECM) remodeling, and cell migration.
Molecular Weight	54 kDa
Amino Acids	411 aa
Exons	11
Pathways	TGF-β
UniProt ID	P00750
NCBI Gene ID	5328
GeneCards	PLAU
Human Protein Atlas	PLAU
Associated Diseases	Als, Alzheimer, Leukemia, Ms
Interactions	ACE, ACE2, ALZHEIMER, AND, BACE1, Bdnf
KG Connections	175 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PLAU — AlphaFold P00750 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PLAU Gene (Urokinase)

gene · 2967 words

→

PLAU Protein

protein · 834 words

→

Pathway Diagram

graph TD
    PLAU["PLAU"] -->|"biomarker for"| Inflammation["Inflammation"]
    PLAU["PLAU"] -->|"biomarker for"| Senescence["Senescence"]
    PLAU["PLAU"] -->|"biomarker for"| Als["Als"]
    PLAU["PLAU"] -->|"biomarker for"| Aging["Aging"]
    PLAU["PLAU"] -->|"biomarker for"| Longevity["Longevity"]
    PLAU["PLAU"] -->|"biomarker for"| Fibrosis["Fibrosis"]
    FGF21["FGF21"] -->|"activates"| PLAU["PLAU"]
    APP["APP"] -->|"biomarker for"| PLAU["PLAU"]
    FNDC5["FNDC5"] -->|"activates"| PLAU["PLAU"]
    S100B["S100B"] -->|"biomarker for"| PLAU["PLAU"]
    style PLAU fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (104)

Target	Relation	Type	Str
Als	biomarker_for	disease	0.65
Als	regulates	disease	0.65
Longevity	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Senescence	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Ms	associated_with	disease	0.65
Apoptosis	biomarker_for	pathway	0.60
PRNP	associated_with	gene	0.60
GHRL	biomarker_for	gene	0.60
MAPT	associated_with	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
IL-6	activates	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
SORL1	associated_with	gene	0.60
IL1A	associated_with	gene	0.60
ACE	associated_with	gene	0.60
IL10	associated_with	gene	0.60
HSPG2	associated_with	gene	0.60
S100A8	activates	gene	0.60
S100A9	activates	gene	0.60
TGM2	activates	gene	0.60
Complement	biomarker_for	pathway	0.60
Fibronectin	activates	protein	0.60
Adiponectin	biomarker_for	protein	0.60
BACE1	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
Leptin	activates	protein	0.60
GENES	biomarker_for	gene	0.60
Ghrelin	biomarker_for	protein	0.60
TGFB1	associated_with	gene	0.60
Amyloid	biomarker_for	pathway	0.60
APOPTOSIS	associated_with	gene	0.60
IL6	associated_with	gene	0.60
IDE	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
Apoptosis	associated_with	pathway	0.60
Jak-Stat	associated_with	pathway	0.60
Akt	associated_with	pathway	0.60
Pi3K	associated_with	pathway	0.60
COMPLEMENT	biomarker_for	gene	0.60
Akt	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
Pi3K	regulates	pathway	0.60
AGING	biomarker_for	gene	0.60

Incoming (71)

Source	Relation	Type	Str
IL10	associated_with	gene	0.60
HMGB1	biomarker_for	gene	0.60
SORL1	associated_with	gene	0.60
IL1A	associated_with	gene	0.60
KL	activates	gene	0.60
ACE	interacts_with	gene	0.60
BACE1	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
IDE	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
AGING	biomarker_for	gene	0.60
TFCP2	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ACE2	activates	gene	0.60
HMGB2	activates	gene	0.60
GBA1	regulates	gene	0.60
VIMENTIN	activates	gene	0.60
ERK	associated_with	gene	0.60
JAK	associated_with	gene	0.60
PI3K	regulates	gene	0.60
LGALS3	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
FGF19	associated_with	gene	0.60
GPNMB	biomarker_for	gene	0.60
CX3CL1	activates	gene	0.60
PROGRANULIN	activates	gene	0.60
BDNF	activates	gene	0.60
FGF23	activates	gene	0.60
TGM2	biomarker_for	gene	0.60
IL6	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
PRNP	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
BACE1	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
GDF15	activates	gene	0.60
CLU	activates	gene	0.60
MMP12	activates	gene	0.60
PDGFA	activates	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
IGF-1	biomarker_for	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
IL-6	activates	gene	0.60
PGRN	activates	gene	0.60
AND	activates	gene	0.60
GENES	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PLAU in their description or question text

No additional research found