gene

CX3CL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CX3CL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

488Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for CX3CL1 — Fractalkine (C-X3-C Motif Chemokine Ligand 1)

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🧬 Gene Info

Gene Symbol	CX3CL1
Full Name	Fractalkine (C-X3-C Motif Chemokine Ligand 1)
Aliases	C-X3-C Motif Chemokine Ligand 1
Chromosome	16q13
Primary Expression	Neurons (cortex, hippocampus), Endothelial cells, Dendritic cells
Amino Acids	373 aa
Pathways	Neuroinflammatory
UniProt ID	P78423
NCBI Gene ID	6376
Ensembl ID	ENSG00000006210
OMIM	601880
GeneCards	CX3CL1
Human Protein Atlas	CX3CL1
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Interactions	AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections	485 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CX3CL1 — AlphaFold P78423 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CX3CL1["CX3CL1"]
    CX3CL1 -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
    CX3CL1 -->|"regulates"| Inflammation["Inflammation"]
    CX3CL1 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    CX3CL1 -->|"target for"| Aging["Aging"]
    CX3CL1 -->|"interacts"| Ms["Ms"]
    CX3CL1 -.biomarker for.-> Senescence["Senescence"]
    CX3CL1 -.biomarker for.-> Als["Als"]
    CX3CL1 -.biomarker for.-> Longevity["Longevity"]
    CX3CR1["CX3CR1"] -->|"target for"| CX3CL1
    FGF21["FGF21"] -->|"activates"| CX3CL1
    APP["APP"] -.biomarker for.-> CX3CL1
    FNDC5["FNDC5"] -->|"activates"| CX3CL1
    S100B["S100B"] -.biomarker for.-> CX3CL1
    PLAU["PLAU"] -->|"activates"| CX3CL1
    CXCL10["CXCL10"] -->|"activates"| CX3CL1
    C1Q["C1Q"] -.biomarker for.-> CX3CL1
    OVERVIEW["OVERVIEW"] -->|"expressed in"| CX3CL1
    FGF23["FGF23"] -->|"activates"| CX3CL1

Outgoing (338)

Target	Relation	Type	Str
Fractalkine	associated_with	protein	0.95
Neurons	interacts_with	cell_type	0.95
Frailty	biomarker_for	phenotype	0.95
Cx3Cr1	binds	protein	0.95
Neuroinflammation	modulates	process	0.95
Microglia	interacts_with	cell_type	0.90
NEURON	expressed_in	cell_type	0.90
Neuron-Glial Signaling	involved_in	pathway	0.90
CX3CR1/AMPK/PPARG Pathway	activates	pathway	0.90
Microglial activation	modulates	process	0.90
Neuron-Glial Signaling	mediates	pathway	0.90
Blood-Brain Barrier	regulates	brain_region	0.90
Neurons	expressed_in	cell_type	0.90
Germinal Matrix Hemorrhage	protects_against	disease	0.85
Frailty	biomarker_for	phenotype	0.85
Neurodegeneration	targets	disease	0.85
neurodegeneration	associated_with	process	0.85
Hematoma Resolution	associated_with	process	0.85
Neurodegenerative Diseases	therapeutic_target	disease	0.85
GNB5	regulates	protein	0.80
neurodegenerative disease	implicated_in	disease	0.80
microglia	expressed_in	cell_type	0.80
neurodegenerative diseases	targets	disease	0.80
Inflammation	activates	disease	0.75
MICROGLIA	mediates	cell_type	0.70
MACROPHAGE	interacts_with	cell_type	0.70
NEURONS	mediates	cell_type	0.70
TREM2	associated_with	gene	0.70
MICROGLIA	regulates	cell_type	0.70
STING	biomarker_for	gene	0.70
MACROPHAGE	targets	cell_type	0.70
CX3CR1	expressed_in	gene	0.70
MICROGLIA	expressed_in	cell_type	0.70
ENDOTHELIAL	activates	cell_type	0.70
MACROPHAGE	disrupts	cell_type	0.70
ENDOTHELIAL	targets	cell_type	0.70
CXCL10	biomarker_for	gene	0.70
NEURONS	expressed_in	cell_type	0.70
NEURONS	transports	cell_type	0.70
CX3CR1	transports	gene	0.70
STAT3	activates	gene	0.70
NEURONS	activates	cell_type	0.70
MICROGLIA	transports	cell_type	0.70
neurons	expressed_in	cell_type	0.70
ALS	activates	disease	0.65
CX3CR1	stabilizes	gene	0.65
Parkinson	expressed_in	disease	0.65
Prion Disease	protects_against	disease	0.65
Epilepsy	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65

Incoming (150)

Source	Relation	Type	Str
Repetitive Transcranial Magnetic Stimulation	upregulates	drug	0.92
h-494861d2	targets	hypothesis	0.90
GABAergic Neuron	produces	cell_type	0.90
miR-125b-5p	downregulates	biomarker	0.85
miR-16-5p	downregulates	biomarker	0.85
ADAM10	regulates	gene	0.70
CCL2	regulates	gene	0.70
ASTROCYTE	reduces	cell_type	0.65
FGF21	activates	gene	0.60
AMYLOID	biomarker_for	gene	0.60
AMPK	activates	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
AND	regulates	gene	0.60
CX3CR1	therapeutic_target	gene	0.60
APP	biomarker_for	gene	0.60
AND	activates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
PGRN	activates	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
INFLAMMATORY GENES	activates	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
DEMENTIA	inhibits	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
SYNAPSE	inhibits	gene	0.60
IL-6	activates	gene	0.60
WNT	inhibits	gene	0.60
EPILEPSY	associated_with	gene	0.60
PARKINSON	expressed_in	gene	0.60
AMYLOID	inhibits	gene	0.60
TAUOPATHY	inhibits	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
MICROGLIA	expressed_in	gene	0.60
ATP	causes	gene	0.60
IL-6	inhibits	gene	0.60
EPILEPSY	inhibits	gene	0.60
DEPRESSION	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
IL-10	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
CCL2	interacts_with	gene	0.60
AGING	therapeutic_target	gene	0.60
ADAM10	associated_with	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
IL-1B	expressed_in	gene	0.60
AD	causes	gene	0.60
AGING	biomarker_for	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CX3CL1-CX3CR1 Mimetic Therapy for Neuroprotection	0.635	neurodegeneration	Microglial subtypes in neurodegeneration
Soluble CX3CL1 cleavage by ADAM proteases disengages fractal	0.540	neurodegeneration	Synaptic pruning by microglia in neurode
CX3CL1 Mimetic Peptide to Disrupt Fractalkine Signaling Dysr	0.470	immunomics	Systemic immune profiling in neurodegene

Mentioning Analyses (1)

Scientific analyses that reference this entity

Microglial subtypes in neurodegeneration — friend vs foe

neurodegeneration | 2026-04-17 | 7 hypotheses Top: 0.685

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning CX3CL1 in their description or question text

No additional research found