gene

CATHEPSIN-B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CATHEPSIN-B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

22Outgoing

1Incoming

0Experiments

0Debates

Summary

CTSB Gene

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🧬 Gene Info

Gene Symbol	CATHEPSIN
GeneCards	CATHEPSIN
Human Protein Atlas	CATHEPSIN
Associated Diseases	Dementia, Alzheimer, Frontotemporal Dementia, Parkinson, Als, Neurodegeneration
Interactions	ALZHEIMER, Bdnf, BDNF, Cytokine, CYTOKINES, Fgf
KG Connections	23 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: CATHEPSIN-B — AlphaFold P07846 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    CATHEPSIN_B["CATHEPSIN-B"]
    Aging{"Aging"}
    CATHEPSIN_B -->|"regulates"| Aging
    Neurodegeneration{"Neurodegeneration"}
    CATHEPSIN_B -->|"activates"| Neurodegeneration
    Diabetes{"Diabetes"}
    CATHEPSIN_B -->|"activates"| Diabetes
    Alzheimer{"Alzheimer"}
    CATHEPSIN_B -->|"activates"| Alzheimer
    ALZHEIMER(["ALZHEIMER"])
    CATHEPSIN_B -->|"activates"| ALZHEIMER
    BDNF(["BDNF"])
    CATHEPSIN_B -->|"activates"| BDNF
    IL_6(["IL-6"])
    IL_6 -->|"regulates"| CATHEPSIN_B
    style CATHEPSIN_B fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (22)

Target	Relation	Type	Str
Diabetes	activates	disease	0.65
Alzheimer	activates	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
AGING	regulates	gene	0.60
FGF21	activates	gene	0.60
IL-6	regulates	gene	0.60
Synaptic Plasticity	activates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Insulin	activates	protein	0.60
Cathepsin	regulates	protein	0.60
Bdnf	activates	protein	0.60
ALZHEIMER	activates	gene	0.60
Cytokine	activates	protein	0.60
BDNF	activates	gene	0.60
IGF-1	activates	gene	0.60
CYTOKINES	activates	gene	0.60
Fgf	activates	protein	0.60
Il-1	regulates	protein	0.60
Igf	activates	protein	0.60
inflammation	regulates	pathway	0.50
aging	regulates	phenotype	0.50

Incoming (1)

Source	Relation	Type	Str
IL-6	regulates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CATHEPSIN-B in their description or question text

No additional research found