concept

IGF-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

283Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	IGF-1
Key Genes/Proteins	Adiponectin, AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt, Amyloid

Wiki Pages (2)

Knowledge base pages for this entity

IGF-1 Signaling Pathway in Neurodegeneration

mechanism · 3993 words

→

IGF-1 Receptor Neurons

cell · 871 words

→

Pathway Diagram

graph TD
    IGF_1["IGF-1"]
    style IGF_1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    IGF_1 -->|"activates"| Myogenesis["Myogenesis"]
    IGF_1 -->|"activates"| PI3K_Akt_mTOR["PI3K-Akt-mTOR"]
    IGF_1 -->|"regulates"| insulin_signaling["insulin signaling"]
    IGF_1 -->|"activates"| Ms["Ms"]
    IGF_1 -.->|"inhibits"| Alzheimer["Alzheimer"]
    IGF_1 -.->|"inhibits"| Aging["Aging"]
    IGF_1 -.->|"inhibits"| Inflammation["Inflammation"]
    IGF_1 -.->|"inhibits"| Als["Als"]
    KIF5B([KIF5B]) -->|"regulates"| IGF_1
    ERK["ERK"] -->|"upstream_of"| IGF_1
    AND([AND]) -->|"activates"| IGF_1
    DNM1L([DNM1L]) -->|"activates"| IGF_1
    NEURON([NEURON]) -->|"activates"| IGF_1
    MICROGLIA([MICROGLIA]) -->|"activates"| IGF_1
    MITOCHONDRIAL_DYSFUNCTION([MITOCHONDRIAL DYSFUNCTION]) -->|"activates"| IGF_1
    MTORC1([MTORC1]) -->|"activates"| IGF_1
    IL_6([IL-6]) -.->|"inhibits"| IGF_1
    BDNF([BDNF]) -->|"activates"| IGF_1

Outgoing (165)

Target	Relation	Type	Str
Synaptic Plasticity	promotes	process	0.85
Myogenesis	activates	process	0.85
PI3K-Akt-mTOR	activates	pathway	0.70
insulin signaling	regulates	pathway	0.70
ALS	activates	disease	0.65
Aging	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Senescence	biomarker_for	disease	0.65
Depression	activates	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Diabetes	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	regulates	disease	0.65
Aging	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
Als	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	contributes_to	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
Mtor	regulates	pathway	0.60
Fibroblast	associated_with	cell_type	0.60
Chemokine	biomarker_for	protein	0.60
OXIDATIVE STRESS	activates	gene	0.60
Bdnf	biomarker_for	protein	0.60
Ghrelin	activates	protein	0.60
Leptin	biomarker_for	protein	0.60
Adiponectin	activates	protein	0.60
Interleukin	activates	protein	0.60
AND	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
AGING	associated_with	gene	0.60
CYTOKINES	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
EXERCISE	activates	gene	0.60

Incoming (118)

Source	Relation	Type	Str
h-47ab2be5	targets	hypothesis	0.90
KL	modulates	protein	0.85
KIF5B	regulates	gene	0.80
ERK	upstream_of	pathway	0.75
IL-6	associated_with	gene	0.66
OXIDATIVE STRESS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
DEPRESSION	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
TRKB	activates	gene	0.60
IFN	activates	gene	0.60
IFN-Γ	activates	gene	0.60
IL-1	activates	gene	0.60
FGF21	activates	gene	0.60
NGF	activates	gene	0.60
MTOR	contributes_to	gene	0.60
IRS1	contributes_to	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
SYP	activates	gene	0.60
EXERCISE	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
CYTOKINES	activates	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
NPY	activates	gene	0.60
TAU	inhibits	gene	0.60
C-JUN	activates	gene	0.60
BDNF	biomarker_for	gene	0.60
ROS	associated_with	gene	0.60
TLR4	activates	gene	0.60
AGING	activates	gene	0.60
PER	activates	gene	0.60
FOXO1	activates	gene	0.60
MTOR	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AKT	activates	gene	0.60
INS	activates	gene	0.60
FGF21	biomarker_for	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
GPNMB	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
VIMENTIN	biomarker_for	gene	0.60
VIM	biomarker_for	gene	0.60
CXCL10	biomarker_for	gene	0.60
CX3CL1	biomarker_for	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
APP	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Fusing IGFBPL1 to IGF-1 for Receptor-Mediated BBB Transcytos	0.552	drug delivery	Can IGFBPL1 therapeutics effectively cro

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IGF-1 in their description or question text

No additional research found