gene 1,001 words KG: FGF19
Contents

FGF19 — Fibroblast Growth Factor 19

🧬 Gene Info
Gene SymbolFGF19
Full NameFibroblast Growth Factor 19
AliasesGene profile: FGF19
Chromosome11q13.1
FunctionUnlike the canonical FGFs (FGF1-FGF10), these metabolic FGFs have low heparin-binding affinity, allowing them to enter circulation.
Primary Expressionthe small intestine (ileum), particularly in enterocytes 2
PathwaysMAPK pathway, PI3K, MAPK
UniProt IDQ9KUM4
NCBI Gene ID2259
Ensembl IDENSG00000162337
GeneCardsFGF19
Human Protein AtlasFGF19
Associated DiseasesAls, Leukemia, Ms
KG Connections47 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57

Related Analyses (3)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (7)

Apoptosis in Neurodegeneration
entity · KG edge: associated_with
CTSD — Cathepsin D
gene · KG edge: regulates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target

Knowledge Graph (12 edges)

FGF21 therapeutic_target FGF19
PI3K regulates FGF19
CTSD regulates FGF19
FGF19 regulates AKT
FGF19 regulates CTSD
LGALS3 associated_with FGF19
PI3K associated_with FGF19
FGF19 associated_with PLAU
FGF19 associated_with AKT
FGF19 associated_with TNF

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