mechanism 1,710 words KG: ent-gene-3bc26681
Contents

FGF13-MTCH2 Neuroprotection in Parkinson's Disease

🔬 Protein Info
Gene SymbolFGF13
Full NameMTCH2 Neuroprotection in Parkinson's Disease
AliasesGene profile: FGF13
ChromosomeXq26.3
Protein TypeChannel
Functionis a member of the FGF family that is predominantly expressed in neuronal tissues, distinguishing it from many other FGFs with broader expression patterns.
Primary Expressionneuronal tissues, distinguishing it from many other FGFs with broader expression patterns
Subcellular Localizationthe cytoplasm and nucleus
PathwaysCalcium Signaling
UniProt IDP15532
NCBI Gene ID2253
GeneCardsFGF13
Human Protein AtlasFGF13
Intracellular localizationFGF13 is primarily localized in the cytoplasm and nucleus
Voltage-gated sodium channel modulationFGF13 binds to and modulates NaV1.2/NaV1.6 sodium channels[@fgf13_channel], regulating neuronal excitability
Associated DiseasesInflammation
InteractionsCAV1, CDK5R2, Fgf, GRM5, ISG15, MICROTUBULES
KG Connections55 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Related Hypotheses (6)

Microbial Inflammasome Priming Prevention
Score: 0.65
Senescent Cell Mitochondrial DNA Release
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Membrane Cholesterol Gradient Modulators
Score: 0.71
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43

Related Analyses (30)

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Related Experiments (30)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-3bc26681 data_in benchmark_ot_ad_answer_key:FGF13
benchmark_ot_ad_answer_key:FGF13 data_in ent-gene-3bc26681

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