biomarker 1,084 words KG: ent-gene-b844ed8e
Contents

Fibroblast Growth Factor 21 (FGF21)

🔬 Protein Info
Gene Symbolent-gene-b844ed8e
Receptor bindingFGFR1c/FGFR3c in the brain
Co-receptor requirementβ-Klotho (KLB gene)
Intracellular signalingMAPK/ERK and PI3K/AKT pathways
Metabolic outcomesImproved insulin sensitivity, increased glucose uptake, reduced hepatic steatosis
ELISACommercial kits (e.g., R&D Systems, Millipore) - sensitivity ~10 pg/mL
Multiplex assaysMeso Scale Discovery platforms for multi-analyte panels
Western BlotFor molecular weight verification and isoform detection
SimoaUltra-sensitive single molecule array for low-abundance detection
KG Connections3 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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