protein

PROGRANULIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROGRANULIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

330Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Progranulin (GRN) is a secreted growth factor involved in neuronal survival, lysosomal function, and inflammation. GRN mutations cause frontotemporal dementia and are linked to Alzheimer's and Parkinson's disease.

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🔬 Protein Info

Gene Symbol	GRN
Aliases	PROGRANULIN
Protein Family	Progranulin family
Function	is a secreted glycoprotein encoded by the <a href="/genes/grn">GRN</a> gene that functions as a crucial regulator of neuronal survival, lysosomal function, and immune response[@baker2006].
Primary Expression	Secreted, Lysosomes, Cytoplasm
Subcellular Localization	Secreted, Lysosomes, Cytoplasm
Molecular Weight	90 kDa
Amino Acids	60 aa
Pathways	Immune Response, Inflammasome, Tdp-43, Toll-Like Receptor, inflammation
UniProt ID	P28799
GeneCards	GRN
Human Protein Atlas	GRN
Associated Diseases	Als, Dementia, disease, Frontotemporal Dementia
Interactions	Actin, AGING, ALZHEIMER, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOE
KG Connections	324 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — PROGRANULIN Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

2JYE — X-ray / Cryo-EM

🔮 AI Predicted Structure

P28799 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Progranulin (PGRN)

protein · 1536 words

→

Pathway Diagram

graph TD
    PROGRANULIN["PROGRANULIN"]
    Neuroinflammation{"Neuroinflammation"}
    PROGRANULIN -->|"activates"| Neuroinflammation
    Aging{"Aging"}
    PROGRANULIN -->|"activates"| Aging
    Inflammation{"Inflammation"}
    PROGRANULIN -->|"activates"| Inflammation
    Alzheimer{"Alzheimer"}
    PROGRANULIN -->|"activates"| Alzheimer
    ALS{"ALS"}
    PROGRANULIN -->|"activates"| ALS
    Huntington{"Huntington"}
    PROGRANULIN -->|"activates"| Huntington
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    PROGRANULIN -->|"activates"| Frontotemporal_Dementia
    Dementia{"Dementia"}
    PROGRANULIN -->|"activates"| Dementia
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    PROGRANULIN -->|"activates"| Amyotrophic_Lateral_Sclerosis
    Parkinson{"Parkinson"}
    PROGRANULIN -->|"activates"| Parkinson
    Prion_Disease{"Prion Disease"}
    PROGRANULIN -->|"activates"| Prion_Disease
    Neurodegeneration{"Neurodegeneration"}
    PROGRANULIN -->|"activates"| Neurodegeneration
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"activates"| PROGRANULIN
    TREM2["TREM2"]
    TREM2 -->|"activates"| PROGRANULIN
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| PROGRANULIN
    GENES["GENES"]
    GENES -->|"activates"| PROGRANULIN
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| PROGRANULIN
    PARKINSON["PARKINSON"]
    PARKINSON -->|"activates"| PROGRANULIN
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"activates"| PROGRANULIN
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| PROGRANULIN
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"activates"| PROGRANULIN
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"activates"| PROGRANULIN
    GPNMB["GPNMB"]
    GPNMB -->|"biomarker for"| PROGRANULIN
    CX3CL1["CX3CL1"]
    CX3CL1 -->|"activates"| PROGRANULIN
    style PROGRANULIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (235)

Target	Relation	Type	Str
SMPD1	regulates	gene	0.90
Microglial Inflammatory Response	inhibits	process	0.85
Microglial Inflammatory Response	inhibits	process	0.85
Microglia	regulates	cell_type	0.80
gene- and cell-based interventions	involved_in	biological_process	0.80
Neuroinflammation	inhibits	process	0.75
TDP-43	regulates	protein	0.70
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.65
Parkinson	contributes_to	disease	0.65
Dementia	associated_with	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.65
Ms	therapeutic_target	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Prion Disease	contributes_to	disease	0.65
Frontotemporal Dementia	biomarker_for	disease	0.65
Alzheimer	contributes_to	disease	0.65
Frontotemporal Dementia	inhibits	disease	0.65
Dementia	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Frontotemporal Dementia	expressed_in	disease	0.65
Schizophrenia	biomarker_for	disease	0.65
Aging	contributes_to	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Ftd	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Frontotemporal Dementia	therapeutic_target	disease	0.65
Als	contributes_to	disease	0.65
Huntington	contributes_to	disease	0.65
ALS	causes	disease	0.65
Alzheimer	expressed_in	disease	0.65
Dementia	biomarker_for	disease	0.65
Als	expressed_in	disease	0.65
Ms	biomarker_for	disease	0.65
Dementia	expressed_in	disease	0.65
ALS	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Neurodegeneration	causes	disease	0.65
Dementia	causes	disease	0.65
Als	causes	disease	0.65
Ftd	causes	disease	0.65
Ms	causes	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	biomarker_for	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	interacts_with	disease	0.65

Incoming (95)

Source	Relation	Type	Str
GRN	encodes	gene	0.70
TREM2	activates	gene	0.60
GPNMB	biomarker_for	gene	0.60
CX3CL1	activates	gene	0.60
CX3CR1	activates	gene	0.60
VIM	activates	gene	0.60
C1Q	biomarker_for	gene	0.60
S100B	biomarker_for	gene	0.60
BDNF	activates	entity	0.60
CXCL10	activates	entity	0.60
FGF21	activates	entity	0.60
FGF23	activates	entity	0.60
FNDC5	activates	entity	0.60
PLAU	activates	entity	0.60
TMEM106B	biomarker_for	gene	0.60
GJA1	activates	gene	0.60
VIMENTIN	activates	gene	0.60
HMGB1	biomarker_for	gene	0.60
APP	biomarker_for	gene	0.60
TGM2	biomarker_for	gene	0.60
TDP-43	activates	gene	0.60
APOE	activates	gene	0.60
SLC1A2	activates	gene	0.60
SMPD1	inhibits	gene	0.60
GAIN	causes	gene	0.60
TDP-43	expressed_in	gene	0.60
TDP-43	therapeutic_target	gene	0.60
GRN	causes	gene	0.60
FUS	expressed_in	gene	0.60
GRN	associated_with	gene	0.60
PGRN	transports	gene	0.60
NEURODEGENERATION	causes	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
IFN	regulates	gene	0.60
GASDERMIN	activates	gene	0.60
DNA	activates	gene	0.60
AQP4	activates	gene	0.60
IRF1	activates	gene	0.60
GRN	transports	gene	0.60
CCR8	transports	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
PARKINSON	activates	gene	0.60
DEMENTIA	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PROGRANULIN in their description or question text

No additional research found