gene

KCNA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

7Outgoing

3Incoming

0Experiments

0Debates

Summary

KCNA1 encodes Kv1.1, a voltage-gated potassium channel critical for neuronal excitability, repolarization, and synaptic transmission

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🧬 Gene Info

Gene Symbol	KCNA1
Full Name	Potassium Voltage-Gated Channel Subfamily A Member 1
Chromosome	12p13.32
Function	is a tetramer of four α-subunits, which can form homomeric (Kv1.
Subcellular Localization	In the central nervous system, Kv1.1 is strategically positioned:
UniProt ID	P09488
NCBI Gene ID	3736
Ensembl ID	ENSG00000111245
OMIM	176260
GeneCards	KCNA1
Human Protein Atlas	KCNA1
Associated Diseases	Als, Epilepsy
KG Connections	10 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNA1 — AlphaFold P09488 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KCNA1["KCNA1"]
    Als{"Als"}
    KCNA1 -->|"causes"| Als
    Epilepsy{"Epilepsy"}
    KCNA1 -->|"causes"| Epilepsy
    FGF14["FGF14"]
    KCNA1 -->|"causes"| FGF14
    Neuron["Neuron"]
    KCNA1 -->|"causes"| Neuron
    Purkinje["Purkinje"]
    KCNA1 -->|"causes"| Purkinje
    Fibroblast["Fibroblast"]
    KCNA1 -->|"causes"| Fibroblast
    Fgf("Fgf")
    KCNA1 -->|"causes"| Fgf
    CACNA1A["CACNA1A"]
    CACNA1A -->|"causes"| KCNA1
    SLC1A3["SLC1A3"]
    SLC1A3 -->|"causes"| KCNA1
    EPILEPSY["EPILEPSY"]
    EPILEPSY -->|"causes"| KCNA1
    neurodegeneration["neurodegeneration"]
    KCNA1 -->|"implicated_in"| neurodegeneration

Outgoing (7)

Target	Relation	Type	Str
Als	causes	disease	0.65
Epilepsy	causes	disease	0.65
Neuron	causes	cell_type	0.60
Fibroblast	causes	cell_type	0.60
Fgf	causes	protein	0.60
FGF14	causes	gene	0.60
Purkinje	causes	cell_type	0.60

Incoming (3)

Source	Relation	Type	Str
EPILEPSY	causes	gene	0.60
CACNA1A	causes	gene	0.60
SLC1A3	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNA1 in their description or question text

No additional research found