protein

GPNMB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GPNMB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

426Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GPNMB is a protein involved in neurodegeneration research. Key relationships include: biomarker for, associated with, activates. Associated with AD, ALI, ALS. Connected to 193 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	GPNMB
Full Name	Glycoprotein Nmb
Chromosome	7p15.3
Function	GPNMB is a type I transmembrane protein with an extracellular domain containing a polycystic kidney disease (PKD) domain and a车位 ITAM-like motif.
Primary Expression	various tissues including brain, bone, and immune cells
Molecular Weight	63.5 kDa
Amino Acids	572 aa
Pathways	Autophagy, Cholesterol, Immune Response, Inflammatory Pathways
UniProt ID	Q14990
NCBI Gene ID	2690
Ensembl ID	ENSG00000136235
GeneCards	GPNMB
Human Protein Atlas	GPNMB
APOE	Interacts with immune responses GPNMB influences
Microglia	Primary central nervous system source of GPNMB
Associated Diseases	AD, ALI, Als, Alzheimer, Alzheimer's disease
Interactions	Actin, Adiponectin, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA
KG Connections	425 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GPNMB — AlphaFold Q14990 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    GPNMB["GPNMB
(Glycoprotein NMB)"]
    
    %% Associated genes/proteins
    APOE["APOE
(Apolipoprotein E)"]
    HMGB1["HMGB1
(High Mobility Group
Box 1 Protein)"]
    NPTX2["NPTX2
(Neuronal Pentraxin 2)"]
    
    %% Pathways
    Complement["Complement
Pathway"]
    Epigenetic["Epigenetic
Regulation"]
    Apoptosis["Apoptosis
Pathway"]
    
    %% Diseases - Protective
    PD_protect["Parkinson's Disease
(Protection)"]
    ALS_protect["ALS
(Protection)"]
    
    %% Diseases - Associated/Biomarker
    AD["Alzheimer's
Disease"]
    MS["Multiple
Sclerosis"]
    
    %% Pathological processes
    Inflammation["Neuroinflammation"]
    Senescence["Cellular
Senescence"]
    Fibrosis["Tissue
Fibrosis"]
    
    %% Beneficial outcomes
    Longevity["Longevity
Promotion"]
    
    %% Connections
    GPNMB -->|"protects against"| PD_protect
    GPNMB -->|"protects against"| ALS_protect
    GPNMB -->|"biomarker for"| AD
    GPNMB -->|"biomarker for"| MS
    GPNMB -->|"activates"| Complement
    GPNMB -->|"activates"| Epigenetic
    GPNMB -->|"activates"| HMGB1
    GPNMB -->|"associated with"| APOE
    GPNMB -->|"associated with"| NPTX2
    GPNMB -->|"biomarker for"| Inflammation
    GPNMB -->|"biomarker for"| Senescence
    GPNMB -->|"biomarker for"| Fibrosis
    GPNMB -->|"biomarker for"| Longevity
    
    Complement -->|"regulates"| Apoptosis
    HMGB1 -->|"promotes"| Inflammation
    Inflammation -->|"contributes to"| AD
    Inflammation -->|"contributes to"| MS
    
    %% Styling
    style GPNMB fill:#006494
    style PD_protect fill:#1b5e20
    style ALS_protect fill:#1b5e20
    style Longevity fill:#1b5e20
    style AD fill:#ef5350
    style MS fill:#ef5350
    style Inflammation fill:#ef5350
    style Senescence fill:#ef5350
    style Fibrosis fill:#ef5350
    style APOE fill:#4a1a6b
    style HMGB1 fill:#4a1a6b
    style NPTX2 fill:#4a1a6b
    style Complement fill:#5d4400
    style Epigenetic fill:#5d4400
    style Apoptosis fill:#5d4400

Outgoing (267)

Target	Relation	Type	Str
Disease-Associated Microglia	expressed_in	cell_type	0.90
Gaucher disease	biomarker_for	disease	0.90
Parkinson's Disease	therapeutic_target	disease	0.85
Parkinson'S Disease	therapeutic_target	disease	0.85
Multiple Sclerosis	biomarker_for	disease	0.85
Neurodegeneration	biomarker_for	process	0.85
Alzheimer's Disease	biomarker_for	disease	0.85
Alzheimer'S Disease	associated_with	disease	0.85
ALZHEIMER'S DISEASE	associated_with	entity	0.80
Inflammatory Response	regulates	process	0.80
GRN	associated_with	gene	0.80
Inflammatory Pathways	regulates	pathway	0.75
Phagocytosis	regulates	process	0.75
amyloidome	involved_in	process	0.70
Parkinson's disease	associated_with	disease	0.70
frontotemporal dementia	associated_with	disease	0.70
Fibrosis	biomarker_for	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Longevity	biomarker_for	disease	0.65
Inflammation	regulates	disease	0.65
Als	activates	disease	0.65
Senescence	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	activates	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
Ftd	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ms	biomarker_for	disease	0.65
Ms	expressed_in	disease	0.65
Epilepsy	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Als	expressed_in	disease	0.65
Ms	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Lewy Body	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Autism	activates	disease	0.65
Ischemia	protects_against	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
Melanoma	expressed_in	disease	0.65
Infection	expressed_in	disease	0.65
Als	protects_against	disease	0.65

Incoming (159)

Source	Relation	Type	Str
VCP	upregulates	gene	0.80
SOD1	upregulates	gene	0.75
CD33	causes	gene	0.70
CR2	causes	gene	0.60
DMSO	therapeutic_target	gene	0.60
CD38	causes	gene	0.60
ADAM15	causes	gene	0.60
MICROGLIA	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
AMYLOID-BETA	interacts_with	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
ERK	therapeutic_target	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
TAU PATHOLOGY	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
PTN	associated_with	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
PARKINSON	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
AGING	biomarker_for	gene	0.60
AMYLOID	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	therapeutic_target	gene	0.60
RAS	therapeutic_target	gene	0.60
LYSOSOME	interacts_with	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
IL-6	activates	gene	0.60
ALS	protects_against	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
MICROGLIA	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
PARKINSON	associated_with	gene	0.60
OLIGODENDROCYTE	activates	gene	0.60
GENES	activates	gene	0.60
NEURON	activates	gene	0.60
MICROGLIA	associated_with	gene	0.60
MICROGLIA	expressed_in	gene	0.60
JAK	activates	gene	0.60
ALS	expressed_in	gene	0.60
ASTROCYTES	interacts_with	gene	0.60
ASTROCYTES	activates	gene	0.60
PHAGOCYTOSIS	protects_against	gene	0.60
ERBB1	causes	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway	0.772	neurodegeneration	View

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (6)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The temporal and stimuli-specific effects of LPS and IFNγ on microglial activati [PMID:41695273]	Heiss CN, Naylor AS, Pesämaa I, Meshi A,	Front Aging Neurosci	2026
CD44 connects autophagy decline and ageing in the vascular endothelium. [PMID:37684253]	Unknown	Nat Commun	2023
The membrane receptor CD44: novel insights into metabolism. [PMID:35249813]	Unknown	Trends Endocrinol Metab	2022
CD44: A Multifunctional Mediator of Cancer Progression. [PMID:34944493]	Unknown	Biomolecules	2021
The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the C [PMID:29519253]	["Matthew L Neal", "Alexa M Boyle", "Kev	Journal of neuroinflammation	2019
HAS2 and CD44 in breast tumorigenesis. [PMID:25081531]	Unknown	Adv Cancer Res	2014

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GPNMB in their description or question text

No additional research found