| Gene Symbol | FGFR3 |
| Aliases | Page for FGFR3 |
| Chromosome | 4p16.3 |
| Protein Family | FGFR tyrosine kinase family |
| Protein Type | Receptor |
| Function | FGFR3 (Fibroblast Growth Factor Receptor 3) is a receptor tyrosine kinase that binds FGFs. |
| Primary Expression | chondrocytes where it negatively regulates bone growth, explaining why activating FGFR3 mutations cause achondroplasia, the most common form of dwarfi |
| Molecular Weight | 88.5 kDa |
| Amino Acids | 808 aa |
| Exons | 19 |
| Pathways | MAPK, PI3K |
| UniProt ID | P22607 |
| GeneCards | FGFR3 |
| Human Protein Atlas | FGFR3 |
| Extracellular Domain | Contains three immunoglobulin-like domains (D1-D3) that mediate FGF binding |
| Associated Diseases | Als, bladder cancer, Breast Cancer, cancer, Carcinoma |
| Interactions | AND, BMPR1A, CANCER, EP300, KDM6A, KMT2D |
| KG Connections | 98 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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