concept

ERK1/2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERK1/2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

439Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ERK1/2
Key Genes/Proteins	6-OHDA, Actin, ADAM17, ADRA2A, ADRA2B, AGING
Related Diseases	Aging, Als, ALS, Alzheimer

Pathway Diagram

graph TD
    ERK1_2["ERK1/2"]
    style ERK1_2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ERK1_2 -->|"interacts"| HSPA1A([HSPA1A])
    ERK1_2 -->|"mediates"| Apoptosis["Apoptosis"]
    ERK1_2 -->|"regulates"| Inflammation["Inflammation"]
    ERK1_2 -->|"mediates"| Astrocyte_Activation["Astrocyte Activation"]
    ERK1_2 -->|"mediates"| Microglia_Activation["Microglia Activation"]
    ERK1_2 -->|"regulates"| neurodegeneration["neurodegeneration"]
    ERK1_2 -->|"regulates"| ADAM17([ADAM17])
    ERK1_2 -->|"activates"| Aging["Aging"]
    ERK1_2 -->|"interacts"| Cancer["Cancer"]
    PRDX1([PRDX1]) -->|"phosphorylates"| ERK1_2
    TGN_020{"TGN-020"} -.->|"inhibits"| ERK1_2
    AKT([AKT]) -.->|"inhibits"| ERK1_2
    oxidative_stress(oxidative stress) -->|"regulates"| ERK1_2
    LL37([LL37]) -->|"interacts"| ERK1_2
    U0126{"U0126"} -.->|"inhibits"| ERK1_2
    CaMKII([CaMKII]) -->|"activates"| ERK1_2
    ADRA2B([ADRA2B]) -->|"activates"| ERK1_2
    SEMA3F([SEMA3F]) -.->|"downregulates"| ERK1_2
    AGING([AGING]) -->|"activates"| ERK1_2

Outgoing (284)

Target	Relation	Type	Str
HSPA1A	interacts_with	gene	0.90
Apoptosis	mediates	process	0.88
Apoptosis	regulates	process	0.85
APOPTOSIS	associated_with	process	0.85
Inflammation	regulates	process	0.85
Apoptosis	associated_with	process	0.80
Microglia Activation	mediates	process	0.78
Astrocyte Activation	mediates	process	0.78
neurodegeneration	regulates	process	0.70
ADAM17	regulates	gene	0.70
Als	activates	disease	0.65
Senescence	activates	disease	0.65
Fibrosis	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ischemia	activates	disease	0.65
Stroke	activates	disease	0.65
Tumor	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Als	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Glioblastoma	regulates	disease	0.65
Stroke	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Als	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Depression	activates	disease	0.65
Neuropathy	transports	disease	0.65
Alzheimer	protects_against	disease	0.65
Aging	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Parkinson	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
Aging	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ischemia	associated_with	disease	0.65
Encephalitis	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
GSK-3Β	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
RNA	inhibits	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60

Incoming (155)

Source	Relation	Type	Str
PRDX1	phosphorylates	protein	0.85
AKT	inhibits	gene	0.80
TGN-020	inhibits	drug	0.80
FGF21	activates	gene	0.80
LL37	interacts_with	protein	0.75
oxidative stress	regulates	phenotype	0.75
U0126	inhibits	drug	0.72
SEMA3F	downregulates	gene	0.70
oxidative stress	modulates	process	0.70
CaMKII	activates	protein	0.70
ADRA2B	activates	gene	0.70
IL-10	activates	gene	0.60
AKT	activates	gene	0.60
PARK2	associated_with	gene	0.60
ROS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
TLR4	activates	gene	0.60
OPA1	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
HSPA1A	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
FGF	activates	gene	0.60
DNA	activates	gene	0.60
GFAP	inhibits	gene	0.60
CHRNA7	inhibits	gene	0.60
MAPK	activates	gene	0.60
MEK	inhibits	gene	0.60
MAPK	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
DDX3X	inhibits	gene	0.60
SIRT7	inhibits	gene	0.60
IBA1	activates	gene	0.60
PI3K	regulates	gene	0.60
MICROGLIA	activates	gene	0.60
FGF1	interacts_with	gene	0.60
PRDX1	activates	gene	0.60
ERK	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
APP	inhibits	gene	0.60
RNA	activates	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
RNA	inhibits	gene	0.60
NGF	activates	gene	0.60
MTORC1	activates	gene	0.60
TLR	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
STROKE	inhibits	gene	0.60
MYELIN	transports	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ERK1/2 in their description or question text

No additional research found