concept

FGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

515Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	FGF
Key Genes/Proteins	Actin, Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
Related Diseases	Aging, ALS, Alzheimer
Related Pathways	Amyloid, Angiogenesis, Apoptosis, apoptosis pathway

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FGF["FGF"]
    style FGF fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    FGF -->|"regulates"| MTOR([MTOR])
    FGF -->|"regulates"| MYELINATION["MYELINATION"]
    FGF -->|"expressed in"| Cancer["Cancer"]
    FGF -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    FGF -->|"regulates"| Alzheimer["Alzheimer"]
    FGF -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    FGF -->|"regulates"| Inflammation["Inflammation"]
    DNA([DNA]) -->|"activates"| FGF
    FGF1([FGF1]) -->|"interacts"| FGF
    ERK1_2([ERK1/2]) -->|"activates"| FGF
    NEURODEGENERATION([NEURODEGENERATION]) -->|"regulates"| FGF
    EXERCISE([EXERCISE]) -->|"regulates"| FGF
    NEUROINFLAMMATION([NEUROINFLAMMATION]) -->|"regulates"| FGF
    MITOCHONDRIAL_DYSFUNCTION([MITOCHONDRIAL DYSFUNCTION]) -->|"regulates"| FGF
    ASTROCYTE([ASTROCYTE]) -->|"regulates"| FGF
    ALZHEIMER([ALZHEIMER]) -->|"regulates"| FGF
    FGF2([FGF2]) -->|"interacts"| FGF

Outgoing (234)

Target	Relation	Type	Str
TFEB	activates	gene	0.70
SQSTM1	activates	gene	0.70
SOD2	activates	gene	0.70
SOD1	activates	gene	0.70
SIRT1	activates	gene	0.70
NEURONS	transports	cell_type	0.70
ULK1	activates	gene	0.70
TGF-beta signaling	participates_in	pathway	0.70
astrocytes	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
ALS	activates	disease	0.65
Glioblastoma	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Cancer	expressed_in	disease	0.65
MTOR	regulates	gene	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
Inflammation	activates	disease	0.65
NEURON	transports	cell_type	0.60
GENES	causes	gene	0.60
AND	causes	gene	0.60
Tgf-Β	causes	pathway	0.60
TH	co_discussed	gene	0.60
AND	activates	gene	0.60
FGF7	activates	gene	0.60
FGFR2	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
APOPTOSIS	causes	gene	0.60
NEURON	co_discussed	cell_type	0.60
MANF	regulates	gene	0.60
Astrocyte Reactivity	associated_with	pathway	0.60
APOPTOSIS	activates	gene	0.60
Raf	expressed_in	protein	0.60
App	expressed_in	protein	0.60
Erk	activates	protein	0.60
Als	regulates	disease	0.60
TAU	regulates	gene	0.60
AMYLOID	regulates	gene	0.60

Incoming (281)

Source	Relation	Type	Str
ATG5	interacts_with	gene	0.70
ATG7	interacts_with	gene	0.70
ASTROCYTE	transports	cell_type	0.70
APOPTOSIS	causes	gene	0.60
ERK1/2	activates	gene	0.60
TP53	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
DNA	inhibits	gene	0.60
B3GALT6	activates	gene	0.60
TSC1	inhibits	gene	0.60
MAPK	inhibits	gene	0.60
PIK3CA	inhibits	gene	0.60
TPR	associated_with	gene	0.60
DNA	therapeutic_target	gene	0.60
ESR1	associated_with	gene	0.60
PBRM1	associated_with	gene	0.60
RB1	associated_with	gene	0.60
PCDH15	associated_with	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
FGFR2	associated_with	gene	0.60
FGFR2	interacts_with	gene	0.60
KRAS	therapeutic_target	gene	0.60
FGFR2	expressed_in	gene	0.60
PDGFRA	inhibits	gene	0.60
RNA	inhibits	gene	0.60
ERBB3	inhibits	gene	0.60
HER3	activates	gene	0.60
NRG1	activates	gene	0.60
PTEN	therapeutic_target	gene	0.60
BRAF	causes	gene	0.60
RNA	therapeutic_target	gene	0.60
EGFR	causes	gene	0.60
AKT1	therapeutic_target	gene	0.60
NF1	therapeutic_target	gene	0.60
KRAS	causes	gene	0.60
NF2	therapeutic_target	gene	0.60
KRAS	inhibits	gene	0.60
MEK	inhibits	gene	0.60
FGFR2	regulates	gene	0.60
MET	inhibits	gene	0.60
FGFR2	inhibits	gene	0.60
DNA	activates	gene	0.60
FGF1	interacts_with	gene	0.60
FGF2	activates	gene	0.60
VEGFB	activates	gene	0.60
BMP2	activates	gene	0.60
RUNX2	activates	gene	0.60
ANGPT1	activates	gene	0.60
PDGFRB	activates	gene	0.60
VEGF	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FGF in their description or question text

No additional research found

FGF

Understanding Entity Pages

Wiki Pages (21)

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FGF10 — Fibroblast Growth Factor 10

FGF23 — Fibroblast Growth Factor 23

FGF Signaling Pathway in Neurodegeneration

FGF7 — Fibroblast Growth Factor 7

FGF Signaling in Parkinson's Disease

FGF6 Gene

FGF8 Gene

FGF21 — Fibroblast Growth Factor 21

FGF16 Gene

FGF13-MTCH2 Neuroprotection in Parkinson's Disease

FGF4 — Fibroblast Growth Factor 4

FGF-2 Protein (bFGF)

AD FGF/FGFR Signaling Companies

FGF17 Protein

FGFR3 - Fibroblast Growth Factor Receptor 3

PD FGF/FGFR Signaling Companies

FGF13 — Fibroblast Growth Factor 13

Fibroblast Growth Factor 21 (FGF21)

FGF14 — Fibroblast Growth Factor 14

FGF19 — Fibroblast Growth Factor 19