protein 1,001 words KG: CTNNB1PROTEIN
Contents

CTNNB1 Protein

🔬 Protein Info
Gene SymbolCTNNB1
Full NameCatenin Beta 1
Chromosome3p22.1
Primary ExpressionUbiquitous, highest in brain
Subcellular LocalizationCytoplasm, nucleus, cell membrane, synapses
Molecular Weight85 kDa
Amino Acids781 aa
PathwaysWnt signaling, Wnt, Wnt pathway
UniProt IDP35222
NCBI Gene ID1499
Ensembl IDENSG00000100994
OMIM116806
GeneCardsCTNNB1
Human Protein AtlasCTNNB1
Associated DiseasesAls, Alzheimer, Blood-Brain Barrier Integrity, Breast Cancer, Cancer, Carcinoma
Known Drugs/Compoundsrapamycin
InteractionsABCD1, ABCD2, ABCD3, ACVR2A, AKT, AKT1
SciDEX HypothesesWnt/β-catenin Pathway Restoration
KG Connections498 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (8)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 4 hypotheses
Cerebral Amyloid Angiopathy in Neurodegeneration
mechanism · Pages share 4 hypotheses
Endosomal-Lysosomal Pathway in Neurodegeneration
mechanism · Pages share 4 hypotheses
Neurovascular Unit Dysfunction in Neurodegeneration
mechanism · Pages share 4 hypotheses

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