gene 2,340 words KG: CTNNB1
Contents

CTNNB1 — Catenin Beta 1

🧬 Gene Info
Gene SymbolCTNNB1
Full NameCatenin Beta 1
Chromosome3p22.1
Primary ExpressionUbiquitous, highest in brain
Molecular Weight85 kDa
Amino Acids781 aa
PathwaysWnt signaling, Wnt, Wnt pathway
UniProt IDP35222
NCBI Gene ID1499
Ensembl IDENSG00000100994
OMIM116806
GeneCardsCTNNB1
Human Protein AtlasCTNNB1
Associated DiseasesAls, Alzheimer, Blood-Brain Barrier Integrity, Breast Cancer, Cancer, Carcinoma
Known Drugs/Compoundsrapamycin
InteractionsABCD1, ABCD2, ABCD3, ACVR2A, AKT, AKT1
SciDEX HypothesesWnt/β-catenin Pathway Restoration
KG Connections495 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (11)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
VCP-Mediated Autophagy Enhancement
Score: 0.59
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57

Related Analyses (5)

Which cell types show the most significant expression change
neurodegeneration · completed
Blood-brain barrier tight junction disruption by neuroinflam
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

AKT1 Gene
gene · KG edge: activates
ARID1A
gene · KG edge: associated_with
ABCD1 — ATP Binding Cassette Subfamily D Member 1
gene · KG edge: activates
ACVR2A Gene
gene · KG edge: activates
APC Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CTNNB1 encodes beta-catenin
LRP1 regulates CTNNB1
CTNNB1 interacts_with TCF3
TCF4 associated_with CTNNB1
MYC associated_with CTNNB1
LC3 associated_with CTNNB1
MTOR associated_with CTNNB1
BECN1 associated_with CTNNB1
CTNNB1 associated_with AXIN2
CTNNB1 associated_with GAPDH

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