concept

JMJD3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JMJD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

8Outgoing

2Incoming

0Experiments

0Debates

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💡 Concept Info

Name	JMJD3
Key Genes/Proteins	ATG7, FGF21, H3K27ME3, PKA, PPARA, TFEB
Related Pathways	AUTOPHAGY, LIPID_DEGRADATION

Wiki Pages (1)

Knowledge base pages for this entity

KDM6B (JMJD3)

gene · 1050 words

→

Pathway Diagram

graph TD
    JMJD3["JMJD3"]
    JMJD3 -->|"upregulates"| Autophagy["Autophagy"]
    JMJD3 -->|"activates"| Lipid_Degradation["Lipid Degradation"]
    JMJD3 -->|"upregulates"| TFEB["TFEB"]
    JMJD3 -->|"upregulates"| ATG7["ATG7"]
    JMJD3 -->|"upregulates"| ATGL["ATGL"]
    JMJD3 -->|"catalyzes"| H3K27me3["H3K27me3"]
    JMJD3 -.biomarker for.-> Non_Alcoholic_Fatty_Liver_Dise["Non-Alcoholic Fatty Liver Disease"]
    JMJD3 -->|"upregulates"| FGF21["FGF21"]
    PKA["PKA"] -->|"phosphorylates"| JMJD3
    FGF21 -->|"activates"| JMJD3

Outgoing (8)

Target	Relation	Type	Str
Non-Alcoholic Fatty Liver Disease	biomarker_for	disease	0.80
AUTOPHAGY	activates	pathway	0.72
LIPID_DEGRADATION	activates	pathway	0.72
H3K27ME3	regulates	protein	0.64
PPARA	interacts_with	protein	0.64
ULK1	regulates	protein	0.64
ATG7	regulates	protein	0.64
TFEB	regulates	protein	0.64

Incoming (2)

Source	Relation	Type	Str
FGF21	activates	protein	0.72
PKA	activates	protein	0.64

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning JMJD3 in their description or question text

No additional research found