protein 2,396 words KG: ATG7
Contents

ATG7 Protein — Autophagy-Related Protein 7

🔬 Protein Info
Gene SymbolATG7
Full NameAutophagy Related 7
Chromosome3p22.1
Protein TypeProtein
Functionis an essential E1-like activating enzyme that plays a central role in the execution of macroautophagy.
Molecular Weight78 kDa
PathwaysAngiogenesis, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
UniProt IDO95352
NCBI Gene ID9459
Ensembl IDENSG00000198271
OMIM607760
GeneCardsATG7
Human Protein AtlasATG7
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compoundscurcumin, CURCUMIN, nicotinamide, rapamycin, RAPAMYCIN
InteractionsACETYL-COA, ACHE, ACSL4, ACTB, Actin, AD
KG Connections1419 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (30)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.67

Related Analyses (18)

Does TRPML1 enhancement cause therapeutic benefit or paradox
neurodegeneration · completed
Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (4)

ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: associated_with
ACTB Gene
gene · KG edge: activates
AIF1 Gene
gene · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: degrades

Knowledge Graph (12 edges)

ATG7 activates ENDOTHELIAL_IMPAIRMENT
ACTB associated_with ATG7
LAMP1 activates ATG7
MTOR activates ATG7
LC3 activates ATG7
TUBB3 activates ATG7
ATG7 activates JUN
ATG7 activates SQSTM1
ATG7 activates MAP2
ATG7 activates SYN1

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