gene

DLK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

0Hypotheses

0Analyses

43Outgoing

20Incoming

0Experiments

0Debates

Summary

DLK1 (Delta-Like 1 Homolog) is a transmembrane protein involved in Notch signaling, cell fate decisions, neurodevelopment, and imprinted gene regulation.

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🧬 Gene Info

Gene Symbol	DLK1
Full Name	Delta Like Non-Canonical Notch Ligand 1
Aliases	Delta-Like 1 Homolog
Chromosome	14q32.12
Function	is a member of the epidermal growth factor (EGF)-like family that functions as a non-canonical Notch ligand and regulator of cell fate decisions.
Amino Acids	396 aa
Exons	8
Pathways	Notch
UniProt ID	[O00548](https://www.uniprot.org/uniprot/O00548)
Ensembl ID	ENSG00000176358
OMIM	176290
GeneCards	DLK1
Human Protein Atlas	DLK1
N-terminal signal peptide	Directs secretion
Multiple EGF-like repeats	Six EGF-like domains in the extracellular region
Associated Diseases	Als, ICPP, Idiopathic Central Precocious Puberty, Ms
Interactions	ACC, ATG12, ATG16L1, ATG5, FERROPTOSIS, GABRA1
KG Connections	63 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DLK1 Gene

gene · 977 words

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Pathway Diagram

graph TD
    DLK1["DLK1"]
    Ms{"Ms"}
    DLK1 -->|"associated with"| Ms
    Als{"Als"}
    DLK1 -->|"associated with"| Als
    DLK1 -->|"interacts with"| Als
    Aging{"Aging"}
    DLK1 -->|"activates"| Aging
    ALS{"ALS"}
    DLK1 -->|"associated with"| ALS
    Epigenetic(["Epigenetic"])
    DLK1 -->|"associated with"| Epigenetic
    Dna_Methylation(["Dna Methylation"])
    DLK1 -->|"associated with"| Dna_Methylation
    GABRA1["GABRA1"]
    DLK1 -->|"associated with"| GABRA1
    DLK1 -->|"interacts with"| GABRA1
    DLK1 -->|"interacts with"| Dna_Methylation
    DLK1 -->|"interacts with"| Epigenetic
    ATG16L1["ATG16L1"]
    DLK1 -->|"inhibits"| ATG16L1
    GABRA1 -->|"associated with"| DLK1
    GAIN["GAIN"]
    GAIN -->|"associated with"| DLK1
    GENES["GENES"]
    GENES -->|"associated with"| DLK1
    DNA["DNA"]
    DNA -->|"associated with"| DLK1
    ATG12["ATG12"]
    ATG12 -->|"inhibits"| DLK1
    TFE3["TFE3"]
    TFE3 -->|"interacts with"| DLK1
    style DLK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (43)

Target	Relation	Type	Str
Idiopathic Central Precocious Puberty	associated_with	disease	0.85
Central Precocious Puberty	risk_factor_for	disease	0.85
ICPP	associated_with	disease	0.80
Ms	associated_with	disease	0.65
Aging	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Als	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Stroke	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Ferroptosis	activates	disease	0.65
Lipid Metabolism	activates	pathway	0.60
Oligodendrocyte	activates	cell_type	0.60
T Cell	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
KISS1	interacts_with	gene	0.60
KISS1R	interacts_with	gene	0.60
FERROPTOSIS	activates	gene	0.60
MKRN3	interacts_with	gene	0.60
ACC	activates	gene	0.60
IL-10	activates	gene	0.60
DNA	associated_with	gene	0.60
GENES	associated_with	gene	0.60
KISS1R	associated_with	gene	0.60
LIN28B	associated_with	gene	0.60
KISS1	associated_with	gene	0.60
TAC3	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
GABRA1	interacts_with	gene	0.60
ATG16L1	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
LC3	activates	gene	0.60
GAIN	associated_with	gene	0.60
Dna Methylation	interacts_with	pathway	0.60
Epigenetic	interacts_with	pathway	0.60
MKRN3	associated_with	gene	0.60
TACR3	associated_with	gene	0.60
Mapk	therapeutic_target	pathway	0.60
Epigenetic	associated_with	pathway	0.60
Dna Methylation	associated_with	pathway	0.60
Differentiation	activates	pathway	0.60
GAIN	interacts_with	gene	0.50

Incoming (20)

Source	Relation	Type	Str
ATG12	inhibits	gene	0.60
TFE3	interacts_with	gene	0.60
ERK1	therapeutic_target	gene	0.60
JNK1	therapeutic_target	gene	0.60
TAK1	therapeutic_target	gene	0.60
P38	therapeutic_target	gene	0.60
UBIQUITIN	activates	gene	0.60
LIN28B	associated_with	gene	0.60
TACR3	associated_with	gene	0.60
MKRN3	associated_with	gene	0.60
KISS1	associated_with	gene	0.60
TAC3	associated_with	gene	0.60
AND	associated_with	gene	0.60
STROKE	activates	gene	0.60
ROS	activates	gene	0.60
KISS1R	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DNA	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
GAIN	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DLK1 in their description or question text

No additional research found