gene 874 words KG: ent-gene-a5287159
Contents

ATG16L1 - Autophagy Related 16 Like 1

🧬 Gene Info
Gene SymbolATG16L1
Full NameAutophagy Related 16 Like 1
Chromosome2q37.1
Functionis a core autophagy protein essential for autophagosome formation and cellular protein quality control.
Primary Expressionneurons and glial cells throughout the brain, including the cortex, [hippocam
Amino Acids607 aa
PathwaysAkt, Autophagy, Epigenetic, Mapk, Mtor
Ensembl IDENSG00000085978
GeneCardsATG16L1
Human Protein AtlasATG16L1
Associated DiseasesInflammation, Intestinal Disease, Osteoarthritis, Parkinson, Rheumatoid Arthritis, Tumor
Known Drugs/Compoundsrapamycin
InteractionsABP, AIM2, AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections559 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

APOE-Dependent Autophagy Restoration
Score: 0.88
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Circadian Clock-Autophagy Synchronization
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Extracellular Matrix Stiffness Modulation
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
VCP-Mediated Autophagy Enhancement
Score: 0.59
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (8)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (1)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40

See Also (12)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
ACTB Gene
gene · KG edge: associated_with
AKT1 Gene
gene · KG edge: regulates
AMBRA1 Gene
gene · KG edge: regulates

Knowledge Graph (2 edges)

ent-gene-a5287159 data_in benchmark_ot_ad_answer_key:ATG16L1
benchmark_ot_ad_answer_key:ATG16L1 data_in ent-gene-a5287159

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