gene

VPS4A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

0Hypotheses

0Analyses

43Outgoing

36Incoming

0Experiments

0Debates

Summary

Page for VPS4A — Vacuolar Protein Sorting 4 Homolog A

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🧬 Gene Info

Gene Symbol	VPS4A
Full Name	Vacuolar Protein Sorting 4 Homolog A
Chromosome	16q22.1
Function	encodes an AAA+ ATPase involved in endosomal sorting, multivesicular body formation, and autophagy.
Molecular Weight	48 kDa
Amino Acids	437 aa
Pathways	Autophagosome-lysosome Fusion, Autophagy, autophagy pathway
UniProt ID	Q9Y5X0
NCBI Gene ID	27183
Ensembl ID	ENSG00000167842
OMIM	609434
GeneCards	VPS4A
Human Protein Atlas	VPS4A
Associated Diseases	neurodegeneration
Known Drugs/Compounds	Aloperine
Interactions	Actin, AMPK, AND, APOPTOSIS, AUTOPHAGY, CANCER
KG Connections	79 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VPS4A — AlphaFold Q9Y5X0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VPS4A — Vacuolar Protein Sorting 4 Homolog A

gene · 1544 words

→

VPS4A Protein — Vacuolar Protein Sorting 4 Homolog A

protein · 607 words

→

Pathway Diagram

graph TD
    VPS4A["VPS4A"]
    Cancer{"Cancer"}
    VPS4A -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    VPS4A -->|"inhibits"| Tumor
    Hepatitis{"Hepatitis"}
    VPS4A -->|"activates"| Hepatitis
    Autophagy(["Autophagy"])
    VPS4A -->|"inhibits"| Autophagy
    Tgf__(["Tgf-Beta"])
    VPS4A -->|"inhibits"| Tgf__
    Apoptosis(["Apoptosis"])
    VPS4A -->|"inhibits"| Apoptosis
    SQSTM1["SQSTM1"]
    VPS4A -->|"inhibits"| SQSTM1
    CANCER["CANCER"]
    VPS4A -->|"inhibits"| CANCER
    APOPTOSIS["APOPTOSIS"]
    VPS4A -->|"inhibits"| APOPTOSIS
    AUTOPHAGY["AUTOPHAGY"]
    VPS4A -->|"inhibits"| AUTOPHAGY
    ROS["ROS"]
    VPS4A -->|"inhibits"| ROS
    AND["AND"]
    VPS4A -->|"interacts with"| AND
    SQSTM1 -->|"inhibits"| VPS4A
    C_JUN["C-JUN"]
    C_JUN -->|"activates"| VPS4A
    CHMP1B["CHMP1B"]
    CHMP1B -->|"activates"| VPS4A
    JUN["JUN"]
    JUN -->|"activates"| VPS4A
    APOPTOSIS -->|"inhibits"| VPS4A
    LYSOSOME["LYSOSOME"]
    LYSOSOME -->|"inhibits"| VPS4A
    AMPK["AMPK"]
    AMPK -->|"activates"| VPS4A
    style VPS4A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (43)

Target	Relation	Type	Str
Autophagosome-lysosome Fusion	regulates	process	0.85
Autophagy	regulates	process	0.85
Neurodegeneration	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Diabetes	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Nafld	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Fatty Liver	regulates	disease	0.65
Lung Cancer	inhibits	disease	0.65
Hepatitis	activates	disease	0.65
Infection	interacts_with	disease	0.65
APOPTOSIS	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
ROS	activates	gene	0.60
CANCER	inhibits	gene	0.60
AND	interacts_with	gene	0.60
Actin	inhibits	protein	0.60
Fus	inhibits	protein	0.60
SQSTM1	inhibits	gene	0.60
Rb	inhibits	protein	0.60
ROS	inhibits	gene	0.60
SREBP1	associated_with	gene	0.60
CANCER	regulates	gene	0.60
SREBF1	associated_with	gene	0.60
TFE3	associated_with	gene	0.60
P62	associated_with	gene	0.60
SPART	associated_with	gene	0.60
ATG14	associated_with	gene	0.60
Autophagy	inhibits	pathway	0.60
Tgf-Β	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
LIPOPHAGY	regulates	gene	0.60
Lysosomal Degradation	associated_with	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
Alzheimer's disease	inhibits	disease	0.55
cancer	inhibits	disease	0.50
LYSOSOME	inhibits	gene	0.50
AUTOPHAGOSOME	inhibits	concept	0.50
TUMOR	inhibits	disease	0.50
CELL DEATH	inhibits	concept	0.50

Incoming (36)

Source	Relation	Type	Str
Aloperine	targets	compound	0.95
Aloperine	binds	compound	0.90
JUN	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
JNK	activates	gene	0.60
SQSTM1	inhibits	gene	0.60
CHMP1B	activates	gene	0.60
CHMP7	interacts_with	gene	0.60
C-JUN	activates	gene	0.60
AND	activates	gene	0.60
LATE	inhibits	entity	0.60
PD-L1	inhibits	gene	0.60
CHMP2B	interacts_with	gene	0.60
CHMP4B	interacts_with	gene	0.60
CANCER	inhibits	gene	0.60
LYSOSOME	inhibits	gene	0.60
NBR1	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
PPARA	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
TFEB	associated_with	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
ROS	inhibits	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
VPS4	inhibits	gene	0.55
VPS4	interacts_with	gene	0.55
ESCRT-III	interacts_with	gene	0.55
AMPK	activates	gene	0.50
TGF	co_expressed_with	protein	0.50
MLKL	co_expressed_with	gene	0.50
late	inhibits	disease	0.50
SQSTM1	co_expressed_with	gene	0.50
Autophagy	inhibits	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VPS4A in their description or question text

No additional research found