Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BECN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Beclin 2 gene encoding a key regulator of autophagy and PI3KIII complex component critical for protein aggregate clearance in neurodegeneration.
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| Gene Symbol | BECN2 |
| Full Name | Beclin 2 |
| Chromosome | 5p15.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various tissues: |
| Molecular Weight | 39 kDa |
| Amino Acids | 349 aa |
| Exons | 14 |
| Pathways | PI3K, PI3K signaling, mTOR, AMPK |
| GeneCards | BECN2 |
| Human Protein Atlas | BECN2 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BECN2["BECN2"]
ATG14["ATG14"]
BECN2 -->|"binds"| ATG14
neurodegeneration["neurodegeneration"]
BECN2 -->|"implicated in"| neurodegeneration
style BECN2 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| ATG14 | binds | protein | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BECN2 in their description or question text
No additional research found