protein 1,438 words KG: ATG14
Contents

ATG14 Protein

🔬 Protein Info
Gene SymbolATG14
Full NameAutophagy Related 14
Chromosome10q26.3
Functionis a crucial autophagy protein that plays a central role in the initiation of autophagosome formation.
Amino Acids492 aa
Exons12
PathwaysApoptosis, Autophagy, Cell Cycle, Epithelial-Mesenchymal Transition, Inflammasome
UniProt IDQ9Y5P8
NCBI Gene ID22889
Ensembl IDENSG00000131725
OMIM614113
GeneCardsATG14
Human Protein AtlasATG14
Associated DiseasesALS, Cancer, dementia, frontotemporal, Infection, Lung Cancer
InteractionsACTB, AIM2, AMPK, AND, APOPTOSIS, AR
KG Connections324 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (12)

APOE-Dependent Autophagy Restoration
Score: 0.88
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Lysosomal Positioning Dynamics Modulation
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (11)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: regulates
ACTB Gene
gene · KG edge: activates
ar
gene · KG edge: activates

Knowledge Graph (12 edges)

ACTB associated_with ATG14
CDC42 associated_with ATG14
CASP3 associated_with ATG14
SQSTM1 regulates ATG14
TUBB3 regulates ATG14
STK11 regulates ATG14
VIM regulates ATG14
BECN1 associated_with ATG14
HDAC6 regulates ATG14
GAPDH associated_with ATG14

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