concept

ATG14L

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG14L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

99Connections

0Hypotheses

0Analyses

50Outgoing

25Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ATG14L
Key Genes/Proteins	AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMBRA1, AND
Related Diseases	Aging, Als, ALS, Alzheimer

Pathway Diagram

graph TD
    ATG14L["ATG14L"]
    ATG14L -->|"activates"| Als["Als"]
    ATG14L -->|"interacts"| Autophagy["Autophagy"]
    ATG14L -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
    ATG14L -.biomarker for.-> ALS["ALS"]
    ATG14L -.biomarker for.-> Aging["Aging"]
    ATG14L -->|"activates"| Tumor["Tumor"]
    ATG14L -->|"activates"| Glioblastoma["Glioblastoma"]
    ATG14L -->|"inhibits"| Renal_Cell_Carcinoma["Renal Cell Carcinoma"]
    ATG["ATG"] -->|"component_of"| ATG14L
    STX17["STX17"] -->|"interacts"| ATG14L
    MITOCHONDRIA["MITOCHONDRIA"] -.biomarker for.-> ATG14L
    ATG14["ATG14"] -.biomarker for.-> ATG14L
    ATG5["ATG5"] -.biomarker for.-> ATG14L
    AUTOPHAGY -->|"interacts"| ATG14L
    PI3K["PI3K"] -->|"interacts"| ATG14L
    AND["AND"] -->|"interacts"| ATG14L
    ATG8["ATG8"] -->|"interacts"| ATG14L

Outgoing (74)

Target	Relation	Type	Str
PI3K Signaling	involved_in	pathway	0.82
Als	activates	disease	0.75
Autophagy	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Autophagy	interacts_with	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Cancer	therapeutic_target	disease	0.65
Infection	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Carcinoma	inhibits	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Glioblastoma	activates	disease	0.65
Tumor	inhibits	disease	0.65
Renal Cell Carcinoma	inhibits	disease	0.65
Als	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
ALS	interacts_with	disease	0.65
ATG14	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
ATG8	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
ATG5	biomarker_for	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
UVRAG	interacts_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
BCL-2	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
SNAP29	interacts_with	gene	0.60
VAMP8	interacts_with	gene	0.60
Fus	interacts_with	protein	0.60
Pi3K	interacts_with	pathway	0.60
Ras	activates	protein	0.60
VPS34	activates	gene	0.60
STX17	interacts_with	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
Ubiquitin	interacts_with	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
ALZHEIMER	inhibits	gene	0.60
LYSOSOME	inhibits	gene	0.60

Incoming (25)

Source	Relation	Type	Str
ATG	component_of	gene	0.80
ULK1	activates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AND	activates	gene	0.60
STX17	interacts_with	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
ATG14	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
PI3K	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
ATG8	interacts_with	gene	0.60
SNAP29	interacts_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AUTOPHAGY	activates	gene	0.60
AGING	inhibits	gene	0.60
LYSOSOME	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
DHHC5	activates	gene	0.60
ATG5	biomarker_for	gene	0.60
ATG5	associated_with	gene	0.50
Autophagy	activates	process	0.50
ATG14	associated_with	gene	0.50
MITOCHONDRIA	associated_with	cell_type	0.50
BECN1	interacts_with	gene	0.50
Pi3K	interacts_with	pathway	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATG14L in their description or question text

No additional research found