gene

SPART

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPART: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

10Outgoing

17Incoming

0Experiments

0Debates

Summary

SPART encodes spartin, a protein involved in lipid droplet metabolism, mitochondrial function, and endosomal trafficking. Mutations cause hereditary spastic paraplegia (SPG20/Troyer syndrome).

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🧬 Gene Info

Gene Symbol	SPART
Full Name	Spartin
Aliases	SPG20/Troyer syndrome
Chromosome	4p16.3
Function	encodes a protein involved in lipid droplet metabolism, mitochondrial function, and endosomal trafficking.
Amino Acids	628 aa
UniProt ID	Q9UQ10
NCBI Gene ID	55037
Ensembl ID	ENSG00000133104
OMIM	607111
GeneCards	SPART
Human Protein Atlas	SPART
Associated Diseases	neurodegeneration
Interactions	AMPK
KG Connections	27 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SPART — AlphaFold Q9UQ10 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SPART — Spartin

gene · 2272 words

→

SPART Protein — Spartin

protein · 667 words

→

Pathway Diagram

graph TD
    SPART["SPART gene"]
    AMPK["AMPK"]
    TFEB["TFEB"]
    TFE3["TFE3"]
    FOXO1["FOXO1"]
    SQSTM1["SQSTM1/p62"]
    NBR1["NBR1"]
    OPTN["OPTN"]
    ATG14["ATG14"]
    LYSOSOMAL["Lysosomal Degradation"]
    LIPOPHAGY["Lipophagy"]
    PPARA["PPARA"]
    SREBP1["SREBP1"]
    NEURODEGENERATION["Neurodegeneration"]
    ALS["ALS"]
    NAFLD["NAFLD"]

    AMPK -->|"activates"| SPART
    SPART -->|"regulates"| LYSOSOMAL
    SPART -->|"associates with"| ATG14
    SPART -->|"associates with"| SQSTM1
    SPART -->|"associates with"| NBR1
    SPART -->|"associates with"| OPTN
    TFEB -->|"regulates"| SPART
    TFE3 -->|"regulates"| SPART
    FOXO1 -->|"regulates"| SPART
    SPART -->|"regulates"| LIPOPHAGY
    LIPOPHAGY -->|"involves"| LYSOSOMAL
    SQSTM1 -->|"mediates"| LYSOSOMAL
    SPART -->|"associates with"| PPARA
    SPART -->|"associates with"| SREBP1
    SPART -->|"regulates"| NEURODEGENERATION
    SPART -->|"regulates"| ALS
    SPART -->|"regulates"| NAFLD

    style SPART fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style AMPK fill:#1b5e20,stroke:#333,stroke-width:2px
    style TFEB fill:#4a1a6b,stroke:#333,stroke-width:2px
    style TFE3 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style FOXO1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style LYSOSOMAL fill:#1b5e20,stroke:#333,stroke-width:2px
    style LIPOPHAGY fill:#1b5e20,stroke:#333,stroke-width:2px
    style NEURODEGENERATION fill:#ef5350,stroke:#333,stroke-width:2px
    style ALS fill:#ef5350,stroke:#333,stroke-width:2px
    style NAFLD fill:#7d4200,stroke:#333,stroke-width:2px

Outgoing (10)

Target	Relation	Type	Str
Fatty Liver	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Nafld	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Lysosomal Degradation	associated_with	pathway	0.60
SREBP1	associated_with	gene	0.60
ATG14	associated_with	gene	0.60

Incoming (17)

Source	Relation	Type	Str
NEURODEGENERATION	regulates	gene	0.60
CANCER	regulates	gene	0.60
LIPOPHAGY	regulates	gene	0.60
P62	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
PPARA	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
VPS4A	associated_with	gene	0.60
SREBF1	associated_with	gene	0.60
TFE3	associated_with	gene	0.60
PSEN1	co_discussed	gene	0.50
PRESENILIN	co_discussed	protein	0.50
AMPK	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SPART in their description or question text

No additional research found