protein

PKM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PKM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

447Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

Page for PKM2 Protein

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🔬 Protein Info

Gene Symbol	PKM2
Function	Pkm2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Primary Expression	Hypothalamus, Thalamus
Subcellular Localization	\| Cytoplasm, Nucleus ! Protein Family \| PKM family </div> ## Overview PKM2 Pro
Molecular Weight	57.9 kDa
Pathways	Glucose Metabolism
GeneCards	PKM2
Human Protein Atlas	PKM2
Associated Diseases	ALS, Alzheimer, Alzheimer's disease, CHEMORESISTANCE, Glioblastoma, Glioma
Known Drugs/Compounds	circFRMD4A, Circfrmd4A, PKM2-IN-1, rapamycin, Shikonin
Interactions	ACAT1, ACC, ACLY, Actin, Akt, AMPK
SciDEX Hypotheses	PKM2 nuclear translocation bridges metabolism and
KG Connections	447 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

PKM2 Metabolic Dysregulation in Alzheimer's Disease

mechanism · 2443 words

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PKM2 Protein

protein · 534 words

→

Pathway Diagram

graph TD
    PKM2("PKM2")
    GLYCOLYSIS["GLYCOLYSIS"]
    PKM2 -->|"involved_in"| GLYCOLYSIS
    PINK1("PINK1")
    PINK1 -->|"phosphorylates"| PKM2
    circFRMD4A["circFRMD4A"]
    circFRMD4A -->|"inhibits"| PKM2
    NEURODEGENERATION["NEURODEGENERATION"]
    PKM2 -->|"therapeutic_target"| NEURODEGENERATION
    PI3K_Akt_Pathway(["PI3K/Akt Pathway"])
    PI3K_Akt_Pathway -->|"phosphorylates"| PKM2
    PRMT1["PRMT1"]
    PRMT1 -->|"phosphorylates"| PKM2
    AKT1("AKT1")
    AKT1 -->|"phosphorylates"| PKM2
    circFRMD4A -->|"interacts_with"| PKM2
    AKT("AKT")
    AKT -->|"phosphorylates"| PKM2
    energy_production["energy production"]
    PKM2 -->|"regulates"| energy_production
    PIN1("PIN1")
    PKM2 -->|"binds"| PIN1
    ERK2("ERK2")
    ERK2 -->|"phosphorylates"| PKM2
    DLAT["DLAT"]
    DLAT -->|"interacts_with"| PKM2
    Akt("Akt")
    Akt -->|"regulates"| PKM2
    DRD2["DRD2"]
    DRD2 -->|"regulates"| PKM2

Outgoing (257)

Target	Relation	Type	Str
GLYCOLYSIS	associated_with	pathway	0.95
Parkinson'S Disease	associated_with	disease	0.92
Parkinson'S Disease	therapeutic_target	disease	0.90
Lactate Production	regulates	process	0.90
Lactate Production	promotes	process	0.90
Lactate	associated_with	compound	0.90
aerobic glycolysis	involved_in	pathway	0.90
Parkinson's disease	worsens	disease	0.90
NEURODEGENERATION	therapeutic_target	entity	0.90
Lactate Production	mediates	process	0.90
STAT3	phosphorylates	protein	0.90
NRF2 Promoter	binds	mechanism	0.90
Parkinsonism	causes	phenotype	0.88
energy production	regulates	process	0.87
PIN1	binds	protein	0.80
chronic neuroinflammation	targets	phenotype	0.70
MICROGLIA	causes	cell_type	0.70
MICROGLIA	regulates	cell_type	0.70
microglial metabolic state	regulates	phenotype	0.70
SIRT1	activates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
Wnt signaling	participates_in	pathway	0.70
Glucose Metabolism	inhibits	process	0.70
Glioblastoma	associated_with	disease	0.65
PARKINSON	exacerbates	disease	0.65
PARKINSON	treats	disease	0.65
Cancer	activates	disease	0.65
Parkinson	inhibits	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Ataxia	activates	disease	0.65
Traumatic Brain Injury	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
LACTATE	causes	phenotype	0.65
Tumor	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Aging	regulates	disease	0.65
Parkinson	activates	disease	0.65
Als	inhibits	disease	0.65
EGFR	regulates	gene	0.65
ALS	expressed_in	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Aging	methylates	disease	0.65

Incoming (190)

Source	Relation	Type	Str
Circfrmd4A	interacts_with	compound	0.95
SIRT1	interacts_with	protein	0.95
Circfrmd4A	inhibits	compound	0.95
PRMT1	associated_with	protein	0.95
SIRT1	associated_with	protein	0.95
PINK1	phosphorylates	protein	0.93
circFRMD4A	inhibits	compound	0.92
circFRMD4A	interacts_with	compound	0.90
PRMT1	phosphorylates	entity	0.90
ESM1	interacts_with	protein	0.90
SUMO1	modulates	protein	0.90
PI3K/AKT	phosphorylates	pathway	0.90
PSMD14	deubiquitinating	protein	0.90
Pi3K/Akt Pathway	phosphorylates	pathway	0.90
Shikonin	inhibits	drug	0.85
UBA2	modulates	protein	0.85
PKM2-IN-1	inhibits	drug	0.85
DLAT	interacts_with	gene	0.80
ERK2	phosphorylates	protein	0.80
MYC	regulates	gene	0.75
PFKFB3	activates	gene	0.70
P53	associated_with	protein	0.65
ACC	activates	gene	0.60
JAK2	activates	gene	0.60
IL-1	inhibits	gene	0.60
PINK1	activates	gene	0.60
PKM	activates	gene	0.60
MLKL	activates	gene	0.60
ABCA7	regulates	gene	0.60
CD68	associated_with	gene	0.60
ACLY	activates	gene	0.60
GLS	activates	gene	0.60
APE1	interacts_with	gene	0.60
CD36	activates	gene	0.60
P21	activates	gene	0.60
ATM	activates	gene	0.60
ROS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
DNA	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
EWSR1	activates	gene	0.60
CANCER	activates	gene	0.60
P53	activates	gene	0.60
CBP	activates	gene	0.60
AMPK	expressed_in	gene	0.60
SLC16A3	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
VAMP8	associated_with	gene	0.60
CCND1	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PKM2 nuclear translocation bridges metabolism and inflammato	0.506	neuroinflammation	Do microglia actually switch between gly

Mentioning Analyses (2)

Scientific analyses that reference this entity

Metabolic reprogramming in neurodegenerative disease

neurodegeneration | 2026-04-02 | 0 hypotheses

Synaptic pruning by microglia in early AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.703

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

Synaptic pruning by microglia in early AD

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning PKM2 in their description or question text

No additional research found