protein

PFKFB3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PFKFB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

221Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming
0Experiments
0Debates

Summary

Page for PFKFB3 Protein

View on Wiki →

No AI portrait yet

🔬 Protein Info
Gene SymbolPFKFB3
FunctionPFKFB3 Protein is a protein involved in various cellular processes.
Subcellular Localizationsignal (NLS) and can translocate to the nucleus, where it may regulate glycolyti
Molecular Weight58 kDa
PathwaysAerobic Glycolysis
GeneCardsPFKFB3
Human Protein AtlasPFKFB3
Associated DiseasesALS, Cancer, Inflammation, Multiple Sclerosis, Neurodegeneration, TRAUMATIC BRAIN INJURY
Known Drugs/CompoundsBergenin
InteractionsAKT, AKT1, AND, APOPTOSIS, App, Bergenin
KG Connections221 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (1)

Knowledge base pages for this entity

PFKFB3 Protein

protein · 598 words

Pathway Diagram

graph TD
    PFKFB3["PFKFB3"]
    Microglial_Glycolytic_Reprogramming(["Microglial Glycolytic Reprogramming"])
    PFKFB3 -->|"activates"| Microglial_Glycolytic_Reprogramming
    Neuroinflammation(["Neuroinflammation"])
    PFKFB3 -->|"mediates"| Neuroinflammation
    Microglia["Microglia"]
    PFKFB3 -->|"expressed in"| Microglia
    Aerobic_Glycolysis(["Aerobic Glycolysis"])
    PFKFB3 -->|"involved in"| Aerobic_Glycolysis
    Bergenin["Bergenin"]
    Bergenin -->|"binds"| PFKFB3
    Bergenin -->|"inhibits"| PFKFB3
    style PFKFB3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (150)

TargetRelationTypeStr
Traumatic Brain Injurydrivesdisease0.95
MICROGLIALexpressed_incell_type0.80
glycolytic-inflammatory crosstalkdrivesprocess0.80
Aerobic Glycolysisinvolved_inprocess0.80
MICROGLIALdrivescell_type0.80

Incoming (71)

SourceRelationTypeStr
PRMT1associated_withprotein0.95
PRMT1phosphorylatesentity0.90
Pi3K/Akt Pathwayphosphorylatespathway0.90
Bergenininteracts_withcompound0.90
h-2a1a95c1targetshypothesis0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PFKFB3 in their description or question text

No additional research found