gene

ape1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ape1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

0Analyses

16Outgoing

10Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	APE1
Full Name	AP Endonuclease 1
Protein Type	Enzyme
Function	APE1 (Apurinic/Apyrimidinic Endonuclease 1) is a essential DNA repair enzyme that plays a critical role in the base excision repair (BER) pathway.
Pathways	NF-κB
Ensembl ID	ENSG00000100823
GeneCards	APE1
Human Protein Atlas	APE1
p53 dysregulation	APE1's redox regulation of p53 is impaired, affecting apoptosis decisions
Mitochondrial vulnerability	dopaminergic neurons rely on APE1 for mtDNA repair
α-synuclein interaction	pathological alpha-synuclein can interfere with APE1's DNA binding and repair function
LRRK2 connection	LRRK2 kinase activity may modulate APE1 function; G2019S mutations affect DNA damage responses
Associated Diseases	Als
Interactions	KEAP1, MITOPHAGY, NRF2, OXIDATIVE STRESS, P62, PARKINSON'S DISEASE
KG Connections	26 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

APE1 — AP Endonuclease 1

gene · 2083 words

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Pathway Diagram

graph TD
    APE1["APE1"]
    APE1 -->|"interacts"| Als["Als"]
    APE1 -->|"interacts"| Ms["Ms"]
    APE1 -->|"inhibits"| Parkinson["Parkinson"]
    APE1 -->|"inhibits"| Tumor["Tumor"]
    APE1 -->|"activates"| Glioblastoma["Glioblastoma"]
    APE1 -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    APE1 -->|"interacts"| Autophagy["Autophagy"]
    APE1 -->|"inhibits"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    P62["P62"] -->|"interacts"| APE1
    KEAP1["KEAP1"] -->|"interacts"| APE1
    SQSTM1["SQSTM1"] -->|"interacts"| APE1
    NRF2["NRF2"] -->|"interacts"| APE1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"inhibits"| APE1
    PARKIN["PARKIN"] -->|"expressed in"| APE1
    UBIQUITIN["UBIQUITIN"] -->|"expressed in"| APE1
    MITOPHAGY["MITOPHAGY"] -->|"inhibits"| APE1

Outgoing (16)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:APE1	data_in	dataset_row	0.00
Tumor	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Als	associated_with	disease	0.65
Glioblastoma	activates	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Oxidative Stress	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
PKM2	interacts_with	gene	0.60
PINK1	inhibits	gene	0.60
Alzheimer's disease	interacts_with	disease	0.60
neurodegeneration	interacts_with	disease	0.60
Mitophagy	inhibits	pathway	0.60
Oxidative Stress	inhibits	pathway	0.60
OXIDATIVE STRESS	inhibits	gene	0.60

Incoming (10)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:APE1	data_in	dataset_row	0.00
P62	interacts_with	gene	0.60
KEAP1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NRF2	interacts_with	gene	0.60
PARKIN	expressed_in	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
MITOPHAGY	inhibits	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ape1 in their description or question text

No additional research found