gene

SUMO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SUMO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

1Hypotheses

0Analyses

12Outgoing

29Incoming

0Experiments

0Debates

Summary

SUMO1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, interacts with, associated with. Associated with ALS, Als, Ms. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SUMO1
Full Name	Small Ubiquitin-Like Modifier 1
Aliases	Page for SUMO1 Protein
Chromosome	2q33
Function	SUMO1 encodes a small ubiquitin-like protein (~101 amino acids) that can be covalently attached to lysine residues in target proteins through an enzymatic cascade involving E1, E2, and E3 enzymes.
Primary Expression	Ubiquitous - High in brain, heart, liver
Molecular Weight	11.6 kDa
Amino Acids	101 aa
UniProt ID	P63165
NCBI Gene ID	7341
Ensembl ID	ENSG00000116030
OMIM	601561
GeneCards	SUMO1
Human Protein Atlas	SUMO1
Associated Diseases	Als
Interactions	AND, ATG12, ATG5, ATG7, HIF1A, LC3
KG Connections	41 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SUMO1 — AlphaFold P63165 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SUMO1 — Small Ubiquitin-Like Modifier 1

gene · 532 words

→

SUMO1 Protein - Small Ubiquitin-Like Modifier 1

protein · 852 words

→

Pathway Diagram

graph TD
    SUMO1["SUMO1"]
    Ms{"Ms"}
    SUMO1 -->|"interacts with"| Ms
    Als{"Als"}
    SUMO1 -->|"associated with"| Als
    ALS{"ALS"}
    SUMO1 -->|"associated with"| ALS
    SUMO2["SUMO2"]
    SUMO1 -->|"interacts with"| SUMO2
    RANBP2["RANBP2"]
    SUMO1 -->|"interacts with"| RANBP2
    UBIQUITIN["UBIQUITIN"]
    SUMO1 -->|"interacts with"| UBIQUITIN
    neurodegeneration["neurodegeneration"]
    SUMO1 -->|"implicated in"| neurodegeneration
    RANBP2 -->|"interacts with"| SUMO1
    MFN1["MFN1"]
    MFN1 -->|"inhibits"| SUMO1
    SENP1["SENP1"]
    SENP1 -->|"activates"| SUMO1
    UBIQUITIN -->|"inhibits"| SUMO1
    NRF1["NRF1"]
    NRF1 -->|"inhibits"| SUMO1
    OPA1["OPA1"]
    OPA1 -->|"inhibits"| SUMO1
    MFN2["MFN2"]
    MFN2 -->|"inhibits"| SUMO1
    TFAM["TFAM"]
    TFAM -->|"inhibits"| SUMO1
    SIRT1["SIRT1"]
    SIRT1 -->|"inhibits"| SUMO1
    AND["AND"]
    AND -->|"interacts with"| SUMO1
    UBIQUITIN -->|"interacts with"| SUMO1
    style SUMO1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
PKM2	modulates	protein	0.90
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
RANBP2	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
Sumo	interacts_with	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
AND	interacts_with	gene	0.60
autophagy pathway	participates_in	pathway	0.60
Alzheimer's disease	activates	disease	0.60
SUMO2	interacts_with	gene	0.60

Incoming (29)

Source	Relation	Type	Str
IR1	catalyzes	enzyme	0.90
RANGAP1	substrate_of	protein	0.90
RANBP2	exhibits_specificity_for	protein	0.90
RANBP2	exhibits_E3_ligase_activity_for	protein	0.90
IR1	binds	protein	0.85
IR2	binds	protein	0.85
OPA1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
MFN1	inhibits	gene	0.60
RANBP2	protects_against	entity	0.60
RANBP2	activates	entity	0.60
SIRT1	inhibits	gene	0.60
SENP1	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
LC3	activates	gene	0.60
ATG12	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
ATG7	inhibits	gene	0.60
HIF1A	inhibits	gene	0.60
ATG12	associated_with	gene	0.60
LC3	associated_with	gene	0.60
AND	interacts_with	gene	0.60
RNA	activates	gene	0.60
DRP1	modulates	gene	0.60
RANBP2	interacts_with	gene	0.60
SUMO2	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs	0.652	neurodegeneration	What are the specific PTM changes in syn

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SUMO1 in their description or question text

No additional research found