gene

EWSR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EWSR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

34Outgoing

9Incoming

0Experiments

0Debates

Summary

EWSR1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, associated with. Associated with Als, Cancer, Ms. Connected to 23 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	EWSR1
Full Name	Ewing Sarcoma Breakpoint Region 1
Chromosome	22q12.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	68.5 kDa
Amino Acids	655 aa
Exons	17
Pathways	oxidative stress response
UniProt ID	Q01844
NCBI Gene ID	2130
Ensembl ID	ENSG00000182944
OMIM	133450
GeneCards	EWSR1
Human Protein Atlas	EWSR1
Exon 1-7	Encodes the N-terminal transactivation domain (QSY-rich)
Associated Diseases	ALS
Interactions	AND, CANCER, FRMD4A, FUS, P53, PKM2
KG Connections	43 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EWSR1 — AlphaFold Q01844 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EWSR1["EWSR1"]
    Ms{"Ms"}
    EWSR1 -->|"expressed in"| Ms
    Cancer{"Cancer"}
    EWSR1 -->|"expressed in"| Cancer
    EWSR1 -->|"therapeutic target"| Cancer
    DDIT3["DDIT3"]
    EWSR1 -->|"associated with"| DDIT3
    YBX1["YBX1"]
    EWSR1 -->|"therapeutic target"| YBX1
    NATURAL_COMPOUNDS["NATURAL COMPOUNDS"]
    EWSR1 -->|"therapeutic target"| NATURAL_COMPOUNDS
    MECP2["MECP2"]
    EWSR1 -->|"therapeutic target"| MECP2
    CANCER["CANCER"]
    EWSR1 -->|"therapeutic target"| CANCER
    HSPA1A["HSPA1A"]
    EWSR1 -->|"therapeutic target"| HSPA1A
    APOPTOSIS["APOPTOSIS"]
    EWSR1 -->|"therapeutic target"| APOPTOSIS
    SYNCRIP["SYNCRIP"]
    EWSR1 -->|"therapeutic target"| SYNCRIP
    G3BP1["G3BP1"]
    EWSR1 -->|"therapeutic target"| G3BP1
    TAF15["TAF15"]
    TAF15 -->|"associated with"| EWSR1
    FUS["FUS"]
    FUS -->|"associated with"| EWSR1
    FLAVONOIDS["FLAVONOIDS"]
    FLAVONOIDS -->|"therapeutic target"| EWSR1
    IGF2BP1["IGF2BP1"]
    IGF2BP1 -->|"therapeutic target"| EWSR1
    style EWSR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (34)

Target	Relation	Type	Str
Circfrmd4A	promotes	compound	0.90
circFRMD4A	associated_with	compound	0.88
Cancer	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Ms	expressed_in	disease	0.65
CANCER	activates	gene	0.60
P53	activates	gene	0.60
FRMD4A	activates	gene	0.60
RNA	activates	gene	0.60
PKM2	activates	gene	0.60
DDIT3	associated_with	gene	0.60
Rb	activates	protein	0.60
Raf	activates	protein	0.60
AND	activates	gene	0.60
NATURAL COMPOUNDS	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
HSPA1A	therapeutic_target	gene	0.60
SYNCRIP	therapeutic_target	gene	0.60
G3BP1	therapeutic_target	gene	0.60
RNA	encodes	gene	0.60
P53	encodes	gene	0.60
FRMD4A	encodes	gene	0.60
YBX1	therapeutic_target	gene	0.60
MECP2	therapeutic_target	gene	0.60
oxidative stress response	participates_in	pathway	0.55
RNA	interacts_with	gene	0.55
FUS	interacts_with	gene	0.55
RNA	binds_to	gene	0.55

Incoming (9)

Source	Relation	Type	Str
P53	activates	gene	0.60
FRMD4A	activates	gene	0.60
FLAVONOIDS	therapeutic_target	gene	0.60
RNA	activates	gene	0.60
CANCER	activates	gene	0.60
TAF15	associated_with	gene	0.60
FUS	associated_with	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
PKM2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EWSR1 in their description or question text

No additional research found