gene

PIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

179Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for PIN1 — Peptidyl-prolyl cis-trans Isomerase NIMA-Interacting 1

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🧬 Gene Info

Gene Symbol	PIN1
Full Name	Peptidyl-prolyl cis-trans Isomerase NIMA-Interacting 1
Protein Type	Isomerase
Function	PIN1 is a unique peptidyl-prolyl cis-trans isomerase (PPIase) that catalyzes the isomerization of peptide bonds preceding phosphorylated serine or threonine residues.
Amino Acids	163 aa
Pathways	MAPK, PI3K, Wnt, NF-κB
Ensembl ID	ENSG00000100429
GeneCards	PIN1
Human Protein Atlas	PIN1
WW Domain	N-terminal domain that recognizes phosphorylated serine/threonine-proline motifs
PPIase Domain	C-terminal catalytic domain that catalyzes cis-trans isomerization
Substrate Specificity	Highly specific for pSer/Thr-Pro motifs, unique among PPIases
Beneficial Function	Catalyzes isomerization of phosphorylated tau, promoting proper tau function
Pathogenic Dysfunction	In AD brain, PIN1 activity is reduced, leading to tau hyperphosphorylation and neurofibrillary tangle formation
Therapeutic Target	PIN1 activators are being explored as potential AD therapeutics
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Cancer, Dementia, Inflammation
Interactions	AD, AND, ANXA2, AΒ, CANCER, CYP46A1
KG Connections	179 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PIN1 — Peptidyl-prolyl cis-trans Isomerase NIMA-Interacting 1

gene · 584 words

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PIN1 Protein

protein · 620 words

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Pathway Diagram

graph TD
    PIN1["PIN1"]
    TRIM32["TRIM32"]
    PIN1 -->|"phosphorylates"| TRIM32
    SUMO2_3["SUMO2/3"]
    PIN1 -->|"binds"| SUMO2_3
    SENP1["SENP1"]
    PIN1 -->|"binds"| SENP1
    NRF2["NRF2"]
    PIN1 -->|"binds"| NRF2
    ANXA2["ANXA2"]
    PIN1 -->|"phosphorylates"| ANXA2
    Alzheimer_s_disease{"Alzheimer's disease"}
    PIN1 -->|"associated with"| Alzheimer_s_disease
    Aging{"Aging"}
    PIN1 -->|"regulates"| Aging
    Neurodegeneration{"Neurodegeneration"}
    PIN1 -->|"regulates"| Neurodegeneration
    Als{"Als"}
    PIN1 -->|"regulates"| Als
    Cancer{"Cancer"}
    PIN1 -->|"regulates"| Cancer
    Longevity{"Longevity"}
    PIN1 -->|"regulates"| Longevity
    Ms{"Ms"}
    PIN1 -->|"regulates"| Ms
    PKM2["PKM2"]
    PKM2 -->|"binds"| PIN1
    AGING["AGING"]
    AGING -->|"regulates"| PIN1
    SIRT6["SIRT6"]
    SIRT6 -->|"regulates"| PIN1
    PARP1["PARP1"]
    PARP1 -->|"regulates"| PIN1
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| PIN1
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"regulates"| PIN1
    P53["P53"]
    P53 -->|"regulates"| PIN1
    MYC["MYC"]
    MYC -->|"regulates"| PIN1
    DDX5["DDX5"]
    DDX5 -->|"regulates"| PIN1
    style PIN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (107)

Target	Relation	Type	Str
TRIM32	modulates	protein	0.85
TRIM32	phosphorylates	protein	0.80
ANXA2	phosphorylates	protein	0.80
SUMO2/3	binds	protein	0.80
SENP1	binds	protein	0.80
TAU	activates	gene	0.70
Alzheimer's disease	associated_with	disease	0.70
Tumor	treats	disease	0.65
Cancer	causes	disease	0.65
Neurodegeneration	treats	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Longevity	regulates	disease	0.65
Ms	regulates	disease	0.65
Tumor	regulates	disease	0.65
Als	regulates	disease	0.65
Als	associated_with	disease	0.65
Inflammation	implicated_in	disease	0.65
Aging	regulates	disease	0.65
Tumor	activates	disease	0.65
Neurodegeneration	causes	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	expressed_in	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Dementia	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
oxidative stress response	participates_in	pathway	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
CANCER	regulates	gene	0.60
AMYLOID	associated_with	gene	0.60
Metastasis	therapeutic_target	pathway	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
AMYLOID	expressed_in	gene	0.60
Mtor	therapeutic_target	pathway	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
Cell Cycle	expressed_in	pathway	0.60
Apoptosis	causes	pathway	0.60
Lysosomal Degradation	activates	pathway	0.60
SREBP2	regulates	gene	0.60
MTORC1	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60

Incoming (72)

Source	Relation	Type	Str
PKM2	binds	protein	0.80
P53	associated_with	gene	0.70
MTOR	biomarker_for	gene	0.65
AMPK	regulates	gene	0.60
NEURONS	activates	cell_type	0.60
CYP46A1	activates	gene	0.60
NEURON	disrupts	cell_type	0.60
AD	regulates	gene	0.60
AD	expresses	gene	0.60
AD	enhances	gene	0.60
AD	activates	gene	0.60
APOPTOSIS	activates	pathway	0.60
NEURON	activates	cell_type	0.60
AΒ	activates	gene	0.60
OXIDATIVE STRESS	activates	pathway	0.60
AD	causes	gene	0.60
DOPAMINERGIC	regulates	cell_type	0.60
NEURON	regulates	cell_type	0.60
NEURONS	regulates	cell_type	0.60
PICALM	expressed_in	gene	0.60
NEURODEGENERATION	treats	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ERK	implicated_in	gene	0.60
APOPTOSIS	regulates	gene	0.60
CANCER	activates	gene	0.60
AND	activates	gene	0.60
APOE	associated_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AND	regulates	gene	0.60
TAU	inhibits	gene	0.60
PI3K	therapeutic_target	gene	0.60
LRP1	associated_with	gene	0.60
JNK	implicated_in	gene	0.60
AGING	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
P53	regulates	gene	0.60
PARP1	regulates	gene	0.60
HNRNPA1	regulates	gene	0.60
MYC	regulates	gene	0.60
DDX5	regulates	gene	0.60
TAU	expressed_in	gene	0.60
APP	associated_with	gene	0.60
CD163	expressed_in	gene	0.60
LAMP2	expressed_in	gene	0.60
APOPTOSIS	causes	gene	0.60
NEURODEGENERATION	causes	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
CANCER	mediates	disease	0.60
SIRT6	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PIN1 in their description or question text

No additional research found