concept

PI3K/AKT PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

202Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

6Debates

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💡 Concept Info

Name	PI3K/AKT PATHWAY
Key Genes/Proteins	AKT, AMYLOID, AXL, BAX, BDNF, CLU
Related Diseases	ANGIOGENESIS, APOPTOSIS, cancer, CELL SURVIVAL, CERAMIDE

Pathway Diagram

graph TD
    PI3K_AKT_PATHWAY["PI3K/AKT PATHWAY"]
    style PI3K_AKT_PATHWAY fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PI3K_AKT_PATHWAY -->|"mediates"| Cancer_Metabolism_Reprogrammin["Cancer Metabolism Reprogramming"]
    PI3K_AKT_PATHWAY -->|"promotes"| breast_cancer_drug_resistance(breast cancer drug resistance)
    PI3K_AKT_PATHWAY -->|"activates"| NRF2([NRF2])
    PI3K_AKT_PATHWAY -->|"phosphorylates"| GLUT1([GLUT1])
    PI3K_AKT_PATHWAY -->|"phosphorylates"| HK2["HK2"]
    PI3K_AKT_PATHWAY -->|"phosphorylates"| PKM2["PKM2"]
    PI3K_AKT_PATHWAY -->|"regulates"| Vascular_Barrier_Function(Vascular Barrier Function)
    PI3K_AKT_PATHWAY -->|"promotes"| TNBC_cell_proliferation["TNBC cell proliferation"]
    PI3K_AKT_PATHWAY -->|"causes"| Cancer_Metabolism(Cancer Metabolism)
    PI3K_AKT_PATHWAY -->|"regulates"| mTORC1([mTORC1])
    nomilin{"nomilin"} -.->|"inhibits"| PI3K_AKT_PATHWAY
    hesperetin{"hesperetin"} -->|"activates"| PI3K_AKT_PATHWAY
    SQDS{"SQDS"} -.->|"inhibits"| PI3K_AKT_PATHWAY
    PI3K_Inhibitor{"PI3K Inhibitor"} -.->|"inhibits"| PI3K_AKT_PATHWAY
    quinolinic_acid["quinolinic acid"] -->|"activates"| PI3K_AKT_PATHWAY
    ANGPT1([ANGPT1]) -->|"activates"| PI3K_AKT_PATHWAY
    TREM1["TREM1"] -->|"activates"| PI3K_AKT_PATHWAY
    REEP1([REEP1]) -->|"regulates"| PI3K_AKT_PATHWAY
    MYC([MYC]) -->|"regulates"| PI3K_AKT_PATHWAY
    TREM2([TREM2]) -->|"activates"| PI3K_AKT_PATHWAY

Outgoing (118)

Target	Relation	Type	Str
Aerobic Glycolysis	associated_with	process	0.95
Cancer	associated_with	disease	0.95
breast cancer drug resistance	promotes	phenotype	0.95
Cancer Metabolism Reprogramming	mediates	process	0.95
Aerobic Glycolysis	promotes	process	0.95
Cancer	associated_with	disease	0.92
GLUT1	phosphorylates	gene	0.90
GLUT1	phosphorylates	protein	0.90
PFKFB3	phosphorylates	gene	0.90
PKM2	phosphorylates	gene	0.90
Vascular Barrier Function	regulates	phenotype	0.90
Cancer Metabolism	modulates	process	0.90
Cancer	drives	disease	0.90
NRF2	activates	protein	0.90
HK2	phosphorylates	gene	0.90
glucose metabolism	regulates	process	0.90
CANCER	implicated_in	disease	0.90
HER2-positive breast cancer	associated_with	disease	0.90
TNBC cell proliferation	promotes	process	0.90
Aβ-Induced Cytotoxicity	protects_against	phenotype	0.90
Cancer Metabolism	causes	phenotype	0.90
triple negative breast cancer	upstream_of	disease	0.88
TNBC Cell Proliferation	regulates	process	0.88
mTORC1	regulates	protein	0.88
HIF-1Α	regulates	protein	0.85
GSK3	regulates	gene	0.85
FOXO	regulates	gene	0.85
Epithelial-Mesenchymal Transition	drives	process	0.85
De Novo Lipid Synthesis	modulates	process	0.85
HIF-1α	regulates	protein	0.85
MTOR	regulates	protein	0.85
MYC	regulates	protein	0.85
Vascular Barrier Function	mediates	phenotype	0.85
Neuroprotection	mediates	process	0.85
Pericyte Recruitment	mediates	process	0.85
neurogenesis	regulates	process	0.85
depression	modulates	disease	0.85
De Novo Lipid Synthesis	modulates	process	0.85
Vascular Barrier Function	mediates	phenotype	0.85
Blood-Brain Barrier Integrity	regulates	pathway	0.85
MEF2	modulates	protein	0.85
MTOR	regulates	gene	0.85
MYC	regulates	gene	0.85
HIF1A	regulates	gene	0.85
Pentose Phosphate Pathway	modulates	process	0.85
MEF2-HDAC Axis	interacts_with	mechanism	0.85
Pentose Phosphate Pathway	regulates	pathway	0.80
Pentose Phosphate Pathway	regulates	pathway	0.80
neuroinflammation	modulates	process	0.80
GABARAPL1	downregulates	gene	0.80

Incoming (84)

Source	Relation	Type	Str
nomilin	inhibits	drug	0.95
Apremilast	activates	drug	0.95
hesperetin	activates	drug	0.90
ANXA1	activates	protein	0.90
PTEN	inhibits	gene	0.90
PTEN	inhibits	gene	0.90
Nomilin	modulates	compound	0.90
SQDS	inhibits	drug	0.90
PI3K Inhibitor	inhibits	drug	0.90
PI3K	part_of	gene	0.90
quinolinic acid	activates	metabolite	0.90
SYK	activates	protein	0.90
ANGPT1	activates	protein	0.85
PDK1	inhibits	gene	0.85
AKT1	part_of	gene	0.80
PI3K	interacts_with	gene	0.80
PI3K	suppresses	gene	0.80
REEP1	regulates	gene	0.80
Ferroptosis	involved_in	process	0.75
MYC	regulates	gene	0.72
NEURON	treats	cell_type	0.70
NEURON	stabilizes	cell_type	0.70
NEURON	inhibits	cell_type	0.70
TREM2	activates	protein	0.70
LY294002	inhibits	drug	0.70
Acupuncture	regulates	process	0.70
QKF	activates	drug	0.70
SCP-oil	activates	drug	0.70
silibinin	inhibits	gene	0.70
merlin	regulates	protein	0.70
TBEV infection	perturbs	process	0.70
SYK	causes	gene	0.70
PDGF	causes	gene	0.70
GSK3β activity	regulated_by	process	0.70
SODIUM BUTYRATE	regulates	drug	0.65
SEPSIS	regulates	disease	0.65
SEPSIS	treats	disease	0.65
BAX	activates	gene	0.65
CLU	activates	gene	0.65
METASTASIS	regulates	phenotype	0.65
METASTASIS	interacts_with	phenotype	0.65
METASTASIS	activates	phenotype	0.65
ASTROCYTES	activates	cell_type	0.65
PERICYTE	interacts_with	concept	0.50
Pi3K	interacts_with	pathway	0.50
Pi3K/Akt	interacts_with	pathway	0.50
MICROGLIAL ACTIVATION	associated_with	phenotype	0.50
EPITHELIAL-MESENCHYMAL TRANSITION	associated_with	phenotype	0.50
ENDOTHELIAL	activates	concept	0.50
Pi3K	expressed_in	pathway	0.50