concept

LACTATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LACTATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

146Connections

7Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	LACTATE
Key Genes/Proteins	AMPK, APP, BDNF, CD47
Related Diseases	AGING, ATP, AUTOPHAGY, CANCER, CELL DEATH
Related Pathways	AMPK SIGNALING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Lactate Lactylation in Neurodegeneration

mechanism · 2167 words

→

Pathway Diagram

graph TD
    LACTATE["LACTATE"]
    LACTATE -->|"causes"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    LACTATE -->|"modulates"| RAB7A["RAB7A"]
    LACTATE -->|"promotes"| CIRP["CIRP"]
    LACTATE -->|"regulates"| HADHA["HADHA"]
    LACTATE -->|"mediates"| Histone_Lactylation["Histone Lactylation"]
    LACTATE -->|"promotes"| Metastasis["Metastasis"]
    LDHA["LDHA"] -->|"regulates"| LACTATE
    SIRT1["SIRT1"] -->|"modulates"| LACTATE
    HK2["HK2"] -->|"regulates"| LACTATE
    ischemia_reperfusion_injury["ischemia-reperfusion injury"] -->|"activates"| LACTATE
    MCT1["MCT1"] -->|"interacts"| LACTATE

Outgoing (95)

Target	Relation	Type	Str
RAB7A	modulates	protein	0.95
HADHA	regulates	protein	0.95
Metastasis	promotes	phenotype	0.95
Hepatocellular Carcinoma	causes	disease	0.95
Hepatocellular Carcinoma	promotes	disease	0.95
CIRP	promotes	protein	0.95
CIRP	promotes	protein	0.95
Histone Lactylation	substrate_of	process	0.95
Histone Lactylation	mediates	process	0.95
RAB7A lactylation	promotes	process	0.92
CIRP	upregulates	protein	0.90
Glioblastoma	contributes_to	disease	0.90
Glioblastoma Stem Cells	regulates	cell_type	0.90
RUBCN	modulates	protein	0.90
CD47	upregulates	gene	0.90
NUPR1	upregulates	gene	0.90
acute lung injury	promotes	disease	0.90
Hepatic Stellate Cell Activation	activates	process	0.90
Glial Activation	causes	process	0.88
RARγ	inhibits	protein	0.88
hepatic ischemia-reperfusion injury	exacerbates	disease	0.88
Glial Activation	promotes	process	0.88
sepsis-induced myocardial depression	promotes	phenotype	0.88
H3K9 Lactylation	promotes	process	0.87
Exosome Biogenesis	upregulates	process	0.87
H3K9 Lactylation	upregulates	process	0.85
PSMD14	upregulates	protein	0.85
Parkinson'S Disease	causes	disease	0.85
Tumor-Derived Exosome Biogenesis	regulates	process	0.85
Cd47-Dependent Immune Evasion	mediates	process	0.85
H3K18 Lactylation	mediates	process	0.85
Renal Ischemia-Reperfusion Injury	promotes	disease	0.82
LCN2	upregulates	gene	0.80
Acute Lung Injury	risk_factor_for	disease	0.80
Hepatocellular Carcinoma	associated_with	disease	0.80
NLRP3	activates	protein	0.70
lactylation	activates	process	0.70
CELL DEATH	produces	phenotype	0.65
GLYCOLYSIS	activates	phenotype	0.65
CD47	causes	gene	0.65
CD47	regulates	gene	0.65
BEVACIZUMAB	activates	drug	0.65
SIRT1	regulates	gene	0.65
CANCER	activates	disease	0.65
MAPK PATHWAY	activates	pathway	0.65
CANCER	regulates	disease	0.65
CANCER	exacerbates	disease	0.65
CELL DEATH	biomarker_for	phenotype	0.65
TUMOR GROWTH	activates	phenotype	0.65
PI3K	activates	gene	0.65

Incoming (51)

Source	Relation	Type	Str
LDHA	regulates	protein	0.95
PKM2	associated_with	gene	0.90
HK2	associated_with	gene	0.85
Gbm Stem Cells	associated_with	cell_type	0.85
Microglia/Macrophages	associated_with	cell_type	0.85
SIRT1	modulates	protein	0.85
HK2	regulates	gene	0.80
Rab7A	associated_with	protein	0.80
ischemia-reperfusion injury	activates	process	0.70
ERK	activates	gene	0.70
LAG3	inhibits	gene	0.65
ENDOTHELIAL CELLS	treats	cell_type	0.65
LRP1	inhibits	gene	0.65
IDH1	produces	gene	0.65
PKM2	causes	gene	0.65
WARBURG EFFECT	causes	phenotype	0.65
PYRUVATE	causes	phenotype	0.65
ERK	phosphorylates	gene	0.65
TUMOR MICROENVIRONMENT	interacts_with	phenotype	0.65
GLIOMA	interacts_with	disease	0.65
AMPK	treats	gene	0.65
SIRT1	interacts_with	gene	0.65
SIRT1	causes	gene	0.65
STAT3	activates	gene	0.65
STAT3	regulates	gene	0.65
NEURODEGENERATION	treats	phenotype	0.60
AMPK	causes	gene	0.60
AMPK	protects_against	gene	0.60
GLYCOLYSIS	causes	phenotype	0.60
GLUTAMATE	activates	phenotype	0.60
ASTROCYTE	targets	cell_type	0.60
ASTROCYTE	treats	cell_type	0.60
OXIDATIVE STRESS	synergizes_with	phenotype	0.60
APP	targets	gene	0.60
LDHA	activates	gene	0.60
HK2	causes	gene	0.60
GLYCOLYSIS	produces	phenotype	0.60
MCT1	interacts_with	protein	0.60
HIPPOCAMPUS	associated_with	brain_region	0.50
SUBSTANTIA NIGRA	associated_with	brain_region	0.50
GRAY MATTER	associated_with	brain_region	0.50
AMPK SIGNALING	associated_with	pathway	0.50
WHITE MATTER	associated_with	brain_region	0.50
METFORMIN	associated_with	drug	0.50
GLIAL FIBRILLARY ACIDIC PROTEIN	associated_with	biomarker	0.45
MAPK PATHWAY	associated_with	pathway	0.45
WNT SIGNALING	associated_with	pathway	0.45
BEVACIZUMAB	associated_with	drug	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
QUERCETIN	associated_with	drug	0.45

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 4: Metabolic Coupling via Lactate-Shuttling Colla	0.892	neurodegeneration	View
Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification	0.677	translational neuroscience	Which metabolic biomarkers can distingui
Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio	0.665	translational neuroscience	Which metabolic biomarkers can distingui
Parvalbumin Interneuron Vulnerability Links Lactate Transpor	0.656	neurodegeneration	What is the molecular mechanism by which
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener	0.529	neurodegeneration	Selective vulnerability of entorhinal co

Astrocyte-Neuron Lactate Shuttle (H6): Metabolic Coupling Re	0.500	neurodegeneration	Does restoring neuronal AMPK activity re
Lactate-HCAR1 signaling maintains a self-reinforcing glycoly	0.427	neuroinflammation	Do microglia actually switch between gly

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (17)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
miR-375 protects against acetaminophen-induced acute liver failure by orchestrat [PMID:40598772]	Wang Y, Liu J, Zhu S, Hu S, Chen X, Mand	Mol Ther	2025	1
Defective thyroid hormone transport to the brain leads to astroglial alterations [PMID:39097035]	Guillén-Yunta M, García-Aldea Á, Valcárc	Neurobiol Dis	2024	1
The SLC16 gene family - structure, role and regulation in health and disease. [PMID:23506875]	Halestrap AP	Mol Aspects Med	2013	1
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Tiratricol: First Approval. [PMID:40549098]	["Lamb Y"]	Drugs	2025	0
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1. [PMID:40680733]	Ge Y, Dou T, Nguyen TU, Yadav GP, Wensel	Cell	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
The interactions between monocarboxylate transporter genes MCT1, MCT2, and MCT4 [PMID:39934699]	Maculewicz E, Mastalerz A, Garbacz A, Mr	BMC genomics	2025	0
Adrenergic regulation of astroglial aerobic glycolysis and lipid metabolism: Tow [PMID:37094775]	["Zorec R", "Vardjan N"]	Neurobiology of disease	2023	0
Tsh Induces Agrp1 Neuron Proliferation in Oatp1c1-Deficient Zebrafish. [PMID:36150888]	Wasserman-Bartov T, Admati I, Lebenthal-	The Journal of neuroscience :	2022	0
The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer. [PMID:34097251]	Sohrabi E, Moslemi M, Rezaie E, Nafissi	Genes & genomics	2021	0
Thyroid Hormone Transporters. [PMID:31754699]	["Groeneweg S", "van Geest F", "Peeters	Endocrine reviews	2020	0
Neural Alterations and Hyperactivity of the Hypothalamic-Pituitary-Thyroid Axis [PMID:31797746]	["Admati I", "Wasserman-Bartov T", "Tovi	Thyroid : official journal of	2020	0
Disease characteristics of MCT8 deficiency: an international, retrospective, mul [PMID:32559475]	Groeneweg S, van Geest FS, Abacı A, Alca	The lancet. Diabetes & endocri	2020	0
Nonbiological maternal risk factor for low birth weight on Latin America: a syst [PMID:23386023]	["da Silva T"]	Einstein (Sao Paulo, Brazil)	2012	0
Thyroid hormone transporters in the brain. [PMID:20879691]	Braun D, Wirth EK, Schweizer U	Reviews in the neurosciences	2010	0
Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome [PMID:16849530]	["Eckerdt F", "Strebhardt K"]	Cancer research	2006	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity