concept

SPINOCEREBELLAR ATAXIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPINOCEREBELLAR ATAXIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

238Connections

0Hypotheses

0Analyses

45Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SPINOCEREBELLAR ATAXIA
Related Diseases	AMYOTROPHIC LATERAL SCLEROSIS, AUTOPHAGY, HUNTINGTON'S DISEASE, PARKINSON'S DISEASE
Related Pathways	DNA DAMAGE RESPONSE

Pathway Diagram

graph TD
    SPINOCEREBELLAR_ATAXIA["SPINOCEREBELLAR ATAXIA"]
    TREHALOSE["TREHALOSE"] -->|"activates"| SPINOCEREBELLAR_ATAXIA
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| SPINOCEREBELLAR_ATAXIA
    ATG10["ATG10"] -->|"activates"| SPINOCEREBELLAR_ATAXIA
    ATG12["ATG12"] -->|"activates"| SPINOCEREBELLAR_ATAXIA
    CALCINEURIN["CALCINEURIN"] -->|"activates"| SPINOCEREBELLAR_ATAXIA
    GENES["GENES"] -->|"activates"| SPINOCEREBELLAR_ATAXIA
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"regulates"| SPINOCEREBELLAR_ATAXIA
    PKC["PKC"] -->|"causes"| SPINOCEREBELLAR_ATAXIA
    PRKCG["PRKCG"] -->|"causes"| SPINOCEREBELLAR_ATAXIA

Outgoing (45)

Target	Relation	Type	Str
PURKINJE CELLS	causes	cell_type	0.65
AMYOTROPHIC LATERAL SCLEROSIS	implicated_in	disease	0.55
Tdp-43	associated_with	pathway	0.55
Sod1	associated_with	pathway	0.55
Mtor	associated_with	pathway	0.55
Autophagy	associated_with	pathway	0.55
Blood-Brain Barrier	inhibits	pathway	0.55
Autophagy	regulates	pathway	0.55
Apoptosis	regulates	pathway	0.55
Mtor	regulates	pathway	0.55
Tdp-43	expressed_in	pathway	0.55
Mtor	expressed_in	pathway	0.55
Proteins	associated_with	protein	0.50
OLIGODENDROCYTES	associated_with	concept	0.50
RAPAMYCIN	activates	concept	0.50
Cortex	associated_with	brain_region	0.50
ALZHEIMER'S	associated_with	concept	0.50
PARKINSON'S	associated_with	concept	0.50
HUNTINGTON'S	associated_with	concept	0.50
Ca1	associated_with	brain_region	0.50
Ca3	associated_with	brain_region	0.50
White Matter	associated_with	brain_region	0.50
Brainstem	associated_with	brain_region	0.50
FRONTOTEMPORAL	expressed_in	concept	0.50
FIBROBLASTS	expressed_in	concept	0.50
CENTRAL NERVOUS SYSTEM	expressed_in	concept	0.50
ALZHEIMER'S	expressed_in	concept	0.50
PARKINSON'S	expressed_in	concept	0.50
HUNTINGTON'S	expressed_in	concept	0.50
STAU1	expressed_in	concept	0.50
Dna Damage Response	activates	pathway	0.50
HOMOLOGOUS RECOMBINATION	activates	concept	0.50
FRONTOTEMPORAL	activates	concept	0.50
DNA DAMAGE	activates	concept	0.50
MOTOR NEURON	activates	concept	0.50
Cerebellum	associated_with	brain_region	0.50
FTLD	regulates	concept	0.50
PARKINSON'S	regulates	concept	0.50
MOTOR NEURON	regulates	concept	0.50
Spinal Cord	associated_with	brain_region	0.50
DNA DAMAGE RESPONSE	associated_with	pathway	0.45
RAPAMYCIN	associated_with	drug	0.45
DEFERIPRONE	associated_with	drug	0.45
LEVODOPA	associated_with	drug	0.45
SODIUM BUTYRATE	associated_with	drug	0.45

Incoming (193)

Source	Relation	Type	Str
AND	causes	gene	0.65
CALB2	regulates	gene	0.65
DNAJC5	regulates	gene	0.65
AUTOPHAGY	causes	phenotype	0.65
HUNTINGTON'S DISEASE	associated_with	gene	0.65
HUNTINGTON	associated_with	gene	0.65
RNA	associated_with	gene	0.65
SMN1	associated_with	gene	0.65
LC3	associated_with	gene	0.65
MTORC1	associated_with	gene	0.65
NEURODEGENERATIVE DISORDERS	regulates	gene	0.65
WIPI2	associated_with	gene	0.65
HTT	associated_with	gene	0.65
NEURON	associated_with	gene	0.65
ACTB	associated_with	gene	0.65
ULK1	associated_with	gene	0.65
SETX	associated_with	gene	0.65
MAP1LC3	associated_with	gene	0.65
DNMT1	associated_with	gene	0.65
ATG7	associated_with	gene	0.65
HUNTINGTIN	associated_with	gene	0.65
GABARAP	associated_with	gene	0.65
GENES	regulates	gene	0.65
ALS4	associated_with	gene	0.65
DEMENTIA	associated_with	gene	0.65
TDP-43	associated_with	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.65
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.65
C9ORF72	expressed_in	gene	0.65
MTOR	expressed_in	gene	0.65
STAU1	expressed_in	gene	0.65
STAU2	associated_with	gene	0.65
NEURODEGENERATION	regulates	gene	0.65
ATXN2	regulates	gene	0.65
ALZHEIMER	associated_with	gene	0.65
AUTOPHAGY	regulates	gene	0.65
RNA	regulates	gene	0.65
C9ORF72	regulates	gene	0.65
MTOR	regulates	gene	0.65
STAU1	associated_with	gene	0.65
NEURODEGENERATIVE DISEASES	regulates	gene	0.65
APOPTOSIS	regulates	gene	0.65
DENDRITE	inhibits	gene	0.65
BRAIN INJURY	inhibits	gene	0.65
ALZHEIMER'S DISEASE	associated_with	gene	0.65
CYP46A1	associated_with	gene	0.65
PARKINSON'S DISEASE	associated_with	gene	0.65
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.65
DNAJB6	inhibits	gene	0.65
DNAJB2	inhibits	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SPINOCEREBELLAR ATAXIA in their description or question text

No additional research found