protein

CACNA1G

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA1G: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

291Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

10Experiments

1Debates

Summary

CACNA1G encodes Cav3.1, the alpha-1G subunit of low-voltage-activated T-type calcium channels involved in neuronal excitability and neurodegeneration.

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🔬 Protein Info

Gene Symbol	CACNA1G
Full Name	Calcium Voltage-Gated Channel Subunit Alpha1 G
Chromosome	17q22
Protein Type	Ion Channel
Target Class	Ion Channel
Function	The CACNA1G gene encodes the α1G subunit that forms the pore of the T-type (low-voltage activated) calcium channel (CaV3.1).
Mechanism of Action	Small molecule blocker of T-type calcium channel activity
Druggability	High (0.90)
Clinical Stage	Approved
Molecular Weight	262 kDa
Pathways	Synaptic function / plasticity
UniProt ID	O43497
NCBI Gene ID	8912
Ensembl ID	ENSG00000006283
GeneCards	CACNA1G
Human Protein Atlas	CACNA1G
Associated Diseases	absence seizures, Ataxia, Autism, epilepsy, Huntington's disease
Known Drugs/Compounds	Nnc-55-0396, SAK3
Interactions	AND, ANK3, APC, APP, ARID1A, ASXL1
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Sleep Spindle-Synaptic Plasticity Enhancement
KG Connections	291 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CACNA1G — AlphaFold O43497 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CACNA1G Gene

gene · 747 words

→

CACNA1G Protein - Cav3.1 T-type Calcium Channel

protein · 1354 words

→

Pathway Diagram

graph TD
    CACNA1G["CACNA1G"]
    neurodegeneration{"neurodegeneration"}
    CACNA1G -->|"implicated in"| neurodegeneration
    CACNA1G -->|"associated with"| neurodegeneration
    ADORA2A["ADORA2A"]
    CACNA1G -->|"co discussed"| ADORA2A
    ADRA2A["ADRA2A"]
    CACNA1G -->|"co discussed"| ADRA2A
    h_8d270062["h-8d270062"]
    h_8d270062 -->|"therapeutic target"| CACNA1G
    h_8d270062 -->|"targets"| CACNA1G
    BMAL1["BMAL1"]
    BMAL1 -->|"co discussed"| CACNA1G
    HCRTR2["HCRTR2"]
    HCRTR2 -->|"co discussed"| CACNA1G
    CLOCK["CLOCK"]
    CLOCK -->|"co discussed"| CACNA1G
    BDNF["BDNF"]
    BDNF -->|"co discussed"| CACNA1G
    AQP4["AQP4"]
    AQP4 -->|"co discussed"| CACNA1G
    MTNR1A["MTNR1A"]
    MTNR1A -->|"co discussed"| CACNA1G
    CX3CR1["CX3CR1"]
    CX3CR1 -->|"co discussed"| CACNA1G
    HCRT["HCRT"]
    HCRT -->|"co discussed"| CACNA1G
    style CACNA1G fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (189)

Target	Relation	Type	Str
Amyloid Beta Production	mediates	process	0.90
Calcium Homeostasis	regulates	process	0.85
Alzheimer's Disease	risk_factor_for	disease	0.85
cerebellum	expressed_in	brain_region	0.80
Pro-amyloidogenic Environment	protects_against	phenotype	0.80
sleep_spindles	generates	phenotype	0.80
Spinocerebellar Ataxia	causes	disease	0.65
Tumor	biomarker_for	disease	0.65
Ataxia	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Ataxia	causes	disease	0.65
Aging	encodes	disease	0.65
Cancer	encodes	disease	0.65
Cancer	activates	disease	0.65
Autism	inhibits	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Autism	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Schizophrenia	inhibits	disease	0.65
Aging	activates	disease	0.65
Als	expressed_in	disease	0.65
Schizophrenia	associated_with	disease	0.65
Dna Methylation	biomarker_for	pathway	0.60
Epigenetic	activates	pathway	0.60
Wnt	activates	pathway	0.60
Neuron	activates	cell_type	0.60
Wnt	expressed_in	pathway	0.60
Epigenetic	encodes	pathway	0.60
P53	encodes	protein	0.60
Bdnf	expressed_in	protein	0.60
neurons	associated_with	cell_type	0.60
cortex	expressed_in	brain_region	0.60
epigenetic regulation	participates_in	pathway	0.60
DNA	methylates	gene	0.60
neurons	expressed_in	cell_type	0.60
oxidative stress response	participates_in	pathway	0.60
AKT	expressed_in	gene	0.60
SHANK3	inhibits	gene	0.60
Rb	activates	protein	0.60
APC	activates	gene	0.60
PMS2	activates	gene	0.60
Purkinje	associated_with	cell_type	0.60
TRKB	expressed_in	gene	0.60
RAB11	expressed_in	gene	0.60
CALB1	biomarker_for	gene	0.60
KMT2A	inhibits	gene	0.60
Neuron	biomarker_for	cell_type	0.60
EPILEPSY	associated_with	gene	0.60
Neuron	associated_with	cell_type	0.60

Incoming (102)

Source	Relation	Type	Str
Nnc-55-0396	inhibits	drug	0.90
Aging	downregulates	process	0.90
h-8d270062	targets	hypothesis	0.90
NEUROG1	biomarker_for	gene	0.60
TP53	activates	gene	0.60
APC	activates	gene	0.60
MLH1	biomarker_for	gene	0.60
PMS2	activates	gene	0.60
CAV3	associated_with	gene	0.60
GAIN	associated_with	gene	0.60
WNT3A	activates	gene	0.60
SETD1A	inhibits	gene	0.60
GAIN	expressed_in	gene	0.60
KMT2B	inhibits	gene	0.60
SHANK3	inhibits	gene	0.60
KMT2D	inhibits	gene	0.60
AXIN2	expressed_in	gene	0.60
CACNA1A	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA2D2	associated_with	gene	0.60
CACNA1F	associated_with	gene	0.60
CACNA1I	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
SLC17A7	biomarker_for	gene	0.60
RAB7	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
RAB5	expressed_in	gene	0.60
RAB11	expressed_in	gene	0.60
EPILEPSY	associated_with	gene	0.60
ARID1A	activates	gene	0.60
CACNA1C	interacts_with	gene	0.60
CACNA1F	interacts_with	gene	0.60
GENES	activates	gene	0.60
AND	associated_with	gene	0.60
GENES	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
GENES	biomarker_for	gene	0.60
CDKN2A	biomarker_for	gene	0.60
CACNA1A	interacts_with	gene	0.60
SAK3	modulates	drug	0.60
LEF1	activates	protein	0.60
beta-catenin	activates	protein	0.60
CDKN2A	associated_with	gene	0.60
ENDOSOMES	expressed_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sleep Spindle-Synaptic Plasticity Enhancement	0.721	neurodegeneration	Sleep disruption as cause and consequenc

Mentioning Analyses (1)

Scientific analyses that reference this entity

Sleep disruption as cause and consequence of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.763

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
DLB Cognitive Fluctuation Mechanism Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$6,550,000
Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Neural Oscillation Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Sleep and Circadian Dysfunction as Driver of Neurodegeneration	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Sleep Disruption and Alzheimer's Disease — mechanism and intervention	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Effects of caffeine on sleep and cognition. [PMID:21531247]	Snel J, Lorist MM	Prog Brain Res	2011	1
Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and [PMID:19536808]	Kunttas-Tatli E, Bose A, Kahali B, Bisho	Genesis	2009	1
CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the [PMID:41654970]	Lu W, Kawatani K, Ren Y	Alzheimers Res Ther	2026	0
Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536]	Zheng ZW, Min PX, Luo YL, Mao XF, Zhang	Neuron	2026	0
Estradiol modulates neuronal network hyperexcitability in select NDD risk genes. [PMID:41757108]	Pruitt A, Yang L, Lee S, Balafkan N, Sea	bioRxiv : the preprint server	2026	0
Vitamin D supplementation and COVID-19 risk: a population-based, cohort study. [PMID:34273098]	["Oristrell J", "Oliva J", "Casado E", "	Journal of endocrinological in	2022	0
Intracellular calcium homeostasis and its dysregulation underlying epileptic sei [PMID:36403388]	Zhou X, Chen Z, Xiao L, Zhong Y, Liu Y,	Seizure	2022	0
Homeostatic plasticity and burst activity are mediated by hyperpolarization-acti [PMID:33547341]	Rátkai A, Tárnok K, Aouad HE, Micska B,	Scientific reports	2021	0
Machine learning reveals bilateral distribution of somatic L1 insertions in huma [PMID:33432196]	["Zhu X", "Zhou B", "Pattni R", "Gleason	Nature neuroscience	2021	0
Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. [PMID:34381213]	["Su Z", "Zhang K", "Kappel K", "Li S",	Nature	2021	0
Prevalence and follow-up of potentially inappropriate medication and potentially [PMID:32641251]	["van Loveren F", "van Berlo-van de Laar	Journal of geriatric oncology	2021	0
COPD exacerbations: finally, a more than ACCEPTable risk score. [PMID:32178778]	Surya P Bhatt	The Lancet. Respiratory medici	2020	0
Neuronal Cav3 channelopathies: recent progress and perspectives. [PMID:32638069]	Lory P, Nicole S, Monteil A	Pflugers Archiv : European jou	2020	0
Single-cell epigenomic analyses implicate candidate causal variants at inherited [PMID:33106633]	["Corces M", "Shcherbina A", "Kundu S",	Nature genetics	2020	0
Reciprocal associations between depression, anxiety and work-related injury. [PMID:31685530]	["Gerasimaviciute V", "B\u00fcltmann U",	Injury prevention : journal of	2020	0
Editorial [PMID:30896375]	Graham John	Cochlear Implants Internationa	2019	0
On-surface synthesis of planar dendrimers via divergent cross-coupling reaction. [PMID:31160575]	["Li D", "Li S", "Xie Y", "Hua X", "Long	Nature communications	2019	0
STAT4 Directs a Protective Innate Lymphoid Cell Response to Gastrointestinal Inf [PMID:31562212]	["Dulson S", "Watkins E", "Crossman D",	Journal of immunology (Baltimo	2019	0
Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of ep [PMID:29728119]	["Ayg\u00f6ren-P\u00fcrs\u00fcn E", "Mag	Orphanet journal of rare disea	2018	0
Predictors of Extended Length of Hospital Stay Following Surgical Repair of Cong [PMID:30171266]	["Azhar A", "Aljefri H"]	Pediatric cardiology	2018	0

Debates (1)

Multi-agent debates referencing this entity

Sleep disruption as cause and consequence of neurodegeneration

closed · Rounds: 4 · Score: 0.91 · 2026-04-06

Related Research

Hypotheses and analyses mentioning CACNA1G in their description or question text

No additional research found