concept

CENTRAL NERVOUS SYSTEM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CENTRAL NERVOUS SYSTEM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

371Connections

0Hypotheses

1Analyses

11Outgoing

50Incoming

0Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	CENTRAL NERVOUS SYSTEM
Key Genes/Proteins	ACTB, AIF1, ALZHEIMER, amyotrophic lateral sclerosis, ANXIETY, APOE
Related Diseases	aging, Alzheimer'S Disease

Pathway Diagram

graph TD
    CENTRAL_NERVOUS_SYSTEM["CENTRAL NERVOUS SYSTEM"]
    CENTRAL_NERVOUS_SYSTEM -->|"modulates"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    CENTRAL_NERVOUS_SYSTEM -->|"modulates"| Glioblastoma_Multiforme["Glioblastoma Multiforme"]
    CENTRAL_NERVOUS_SYSTEM -->|"expressed in"| Autophagy["Autophagy"]
    GPR37["GPR37"] -->|"expressed in"| CENTRAL_NERVOUS_SYSTEM
    BI_hTFR1["BI-hTFR1"] -->|"mediates"| CENTRAL_NERVOUS_SYSTEM
    AQP4["AQP4"] -->|"expressed in"| CENTRAL_NERVOUS_SYSTEM
    PIEZO1["PIEZO1"] -->|"involved_in"| CENTRAL_NERVOUS_SYSTEM
    Gut_Microbiota["Gut Microbiota"] -->|"modulates"| CENTRAL_NERVOUS_SYSTEM
    Gut_Brain_Axis["Gut-Brain Axis"] -->|"mediates"| CENTRAL_NERVOUS_SYSTEM
    Microglia["Microglia"] -->|"expressed in"| CENTRAL_NERVOUS_SYSTEM
    Microbiota_Gut_Brain_Axis["Microbiota-Gut-Brain Axis"] -->|"interacts"| CENTRAL_NERVOUS_SYSTEM

Outgoing (11)

Target	Relation	Type	Str
Hepatocellular Carcinoma	modulates	disease	0.95
Neuromyelitis Optica Spectrum Disorder	involved_in	disease	0.90
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease	involved_in	disease	0.90
limited self-repair potential	associated_with	phenotype	0.85
Glioblastoma Multiforme	modulates	disease	0.85
Self-Repair Potential	associated_with	phenotype	0.85
Limited Neuroregeneration	associated_with	phenotype	0.85
Glioblastoma Multiforme	regulates	disease	0.80
Cellular Senescence	expressed_in	process	0.80
Autophagy	expressed_in	process	0.80
Neuroregeneration	associated_with	process	0.75

Incoming (360)

Source	Relation	Type	Str
Bi-Htfr1	mediates	drug	0.98
Bi-Htfr1	targets	drug	0.96
Microbiota-Gut-Brain Axis	interacts_with	pathway	0.95
AQP4	expressed_in	protein	0.95
CRISPR	targets	process	0.95
Multiple Sclerosis	associated_with	disease	0.95
Viral Vector Gene Therapy	targets	drug	0.95
Cns Extracellular Matrix	expressed_in	biomarker	0.95
Aav-Php.Eb	targets	compound	0.95
PIEZO1	involved_in	gene	0.95
SHH	expressed_in	protein	0.95
Gut-Brain Axis	mediates	pathway	0.95
HCN	expressed_in	protein	0.95
AQUAPORINS	expressed_in	protein	0.95
AAV-PHP.eB	targets	drug	0.95
Gut Microbiota	associated_with	process	0.95
BI-hTFR1	mediates	drug	0.95
Microglia	expressed_in	cell_type	0.95
TFRC	associated_with	protein	0.92
AAV-PHP.eB	involved_in	drug	0.92
TREM2	expressed_in	protein	0.92
41787076	demonstrated sustained target engagement in	paper	0.90
CNS Extracellular Matrix Components	expressed_in	protein	0.90
Tissue-Sensing T Cells	targets	cell_type	0.90
MICROBIOTA	communicates_with	cell_type	0.90
AQP1	expressed_in	gene	0.90
40500504	is susceptible to	paper	0.90
Hsp90 inhibitors	causes	drug	0.90
AAVT42	targets	drug	0.90
AQP5	expressed_in	gene	0.90
AQP3	expressed_in	gene	0.90
AQP9	expressed_in	gene	0.90
25673413	plays a role in	paper	0.90
25673413	has strong support for a role in	paper	0.90
sleep	associated_with	process	0.90
Piezo1	associated_with	gene	0.90
canonical SHH pathway	involved_in	pathway	0.90
gut	interacts_with	brain_region	0.90
Oligonucleotide Transport Vehicle	involved_in	drug	0.88
TAU	expressed_in	protein	0.85
Neuroinflammation	expressed_in	process	0.85
Autophagy	involved_in	process	0.85
Vagus Nerve Pathway	mediates	pathway	0.85
Crispr-Cas9 Gene Therapy	involved_in	drug	0.85
FTLD-TDP Type C	expressed_in	disease	0.85
HCN1	expressed_in	gene	0.85
Gut-Brain Axis	modulates	pathway	0.85
Myeloid Cells	involved_in	cell_type	0.85
Gut Microbiota	interacts_with	cell_type	0.85
Protein Filamentous Assembly	expressed_in	process	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can chaperone enhancement approaches overcome tau seed saturation effects in adv

protein folding | 2026-04-06 | 13 hypotheses Top: 0.765

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While DNAJB1 enhancement showed promise, the debate raised concerns about whethe

closed · Rounds: 4 · Score: 0.73 · 2026-04-22

Related Research

Hypotheses and analyses mentioning CENTRAL NERVOUS SYSTEM in their description or question text

No additional research found