concept

WHITE MATTER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WHITE MATTER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

604Connections

13Hypotheses

0Analyses

50Outgoing

50Incoming

4Experiments

0Debates

Summary

WHITE MATTER is a concept in neurodegeneration research. Key relationships include: co discussed, activates, causes. Associated with ALS, ANXIETY, DEMENTIA. Connected to 36 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	WHITE MATTER
Key Genes/Proteins	ABI3, AKT, AMPK, AMYLOID, APOE, APOE4
Related Diseases	AGING, ALS, ALZHEIMER'S DISEASE, ANXIETY
Related Pathways	AMPK SIGNALING

Pathway Diagram

graph TD
    WHITE_MATTER["WHITE MATTER"]
    AQUAPORIN_4["AQUAPORIN-4"] -->|"expressed in"| WHITE_MATTER
    MYELIN["MYELIN"] -->|"expressed in"| WHITE_MATTER
    OLIGODENDROCYTE["OLIGODENDROCYTE"] -->|"expressed in"| WHITE_MATTER
    AQP4["AQP4"] -->|"expressed in"| WHITE_MATTER
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"expressed in"| WHITE_MATTER
    JAM2["JAM2"] -->|"expressed in"| WHITE_MATTER
    JUN["JUN"] -->|"expressed in"| WHITE_MATTER
    GENES["GENES"] -->|"expressed in"| WHITE_MATTER
    XPR1["XPR1"] -->|"expressed in"| WHITE_MATTER
    SLC20A2["SLC20A2"] -->|"expressed in"| WHITE_MATTER

Outgoing (116)

Target	Relation	Type	Str
APOE	regulates	gene	0.70
APOE	stabilizes	gene	0.70
PROTEIN AGGREGATION	stabilizes	phenotype	0.70
NEURODEGENERATION	increases_risk	phenotype	0.70
LIPID PEROXIDATION	causes	phenotype	0.70
PROTEIN AGGREGATION	activates	phenotype	0.70
APOE	treats	gene	0.70
NEURON	stabilizes	cell_type	0.70
ALS	treats	disease	0.70
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
ALZHEIMER'S DISEASE	regulates	disease	0.65
PSEN1	interacts_with	gene	0.65
NECROPTOSIS	regulates	phenotype	0.65
TRAUMATIC BRAIN INJURY	causes	disease	0.65
TREM2	regulates	gene	0.65
MICROGLIA	associated_with	cell_type	0.65
CORPUS CALLOSUM	treats	brain_region	0.60
FORNIX	treats	brain_region	0.60
FORNIX	stabilizes	brain_region	0.60
TAU	targets	protein	0.60
ALZHEIMER'S DISEASE	implicated_in	disease	0.60
SENESCENCE	associated_with	phenotype	0.50
MTOR	associated_with	gene	0.50
PI3K	associated_with	gene	0.50
AKT	associated_with	gene	0.50
TNF	associated_with	gene	0.50
SYK	associated_with	gene	0.50
OLIG2	associated_with	gene	0.50
MBP	associated_with	gene	0.50
GENE EXPRESSION	expressed_in	concept	0.50
DEMYELINATION	associated_with	concept	0.50
HDAC3	associated_with	gene	0.50
FRONTAL	interacts_with	concept	0.50
REMYELINATION	activates	concept	0.50
ISCHEMIC	activates	concept	0.50
MICROGLIAL ACTIVATION	activates	concept	0.50
CSF	associated_with	phenotype	0.50
LACTATE	associated_with	phenotype	0.50
CEREBRAL CORTEX	associated_with	concept	0.50
REMYELINATION	inhibits	concept	0.50
GRAY MATTER	associated_with	concept	0.50
DEMYELINATION	causes	concept	0.50
GRAY MATTER	causes	concept	0.50
OLIGODENDROCYTES	associated_with	concept	0.50
APP	associated_with	gene	0.50
PERICYTE	associated_with	cell_type	0.50
CXCL10	associated_with	gene	0.50
T CELLS	associated_with	cell_type	0.50
L-DOPA	associated_with	drug	0.50

Incoming (488)

Source	Relation	Type	Str
multiple sclerosis	affects	disease	0.90
Aging	causes	process	0.90
Microglia	associated_with	cell_type	0.88
Microglia Nodules	expressed_in	phenotype	0.88
TAU	associated_with	protein	0.85
aging	affects	disease	0.80
neuroinflammation	affects	disease	0.80
neurodegeneration	affects	disease	0.80
axon	enriched_in	organelle	0.70
GRAY MATTER	treats	brain_region	0.70
GRAY MATTER	stabilizes	brain_region	0.70
AGING	stabilizes	phenotype	0.70
ALS	stabilizes	disease	0.70
CYP46A1	activates	gene	0.70
ferroptosis	active_in	pathway	0.70
traumatic brain injury	affects	disease	0.70
AGING	treats	phenotype	0.70
MICROGLIAL ACTIVATION	treats	phenotype	0.70
STROKE	protects_against	disease	0.65
OLIGODENDROCYTES	activates	cell_type	0.65
GLUTAMATE	produces	phenotype	0.65
TRAUMATIC BRAIN INJURY	contributes_to	disease	0.65
TAU	phosphorylates	gene	0.65
CORTEX	phosphorylates	brain_region	0.65
CORTEX	reduces	brain_region	0.65
OLIGODENDROCYTES	causes	cell_type	0.65
NRF2	activates	gene	0.65
STING	activates	gene	0.65
OLIGODENDROCYTE	causes	cell_type	0.65
BASAL GANGLIA	activates	brain_region	0.65
CURCUMIN	treats	drug	0.65
ENTORHINAL	reduces	brain_region	0.65
NRF2	promotes	gene	0.65
PHAGOCYTOSIS	inhibits	phenotype	0.65
VEGFA	interacts_with	gene	0.65
OLIGODENDROCYTE	regulates	cell_type	0.65
AGING	exacerbates	phenotype	0.65
MACROPHAGES	causes	cell_type	0.65
GLUTAMATE	transports	phenotype	0.65
GLUTAMATE	targets	phenotype	0.65
MICROGLIA	protects_against	cell_type	0.65
CHOLESTEROL	activates	phenotype	0.65
NRF2	regulates	gene	0.65
SMPD1	inhibits	gene	0.65
NEURON	associated_with	cell_type	0.65
ISCHEMIC	causes	disease	0.65
NEURON	expressed_in	cell_type	0.65
CHOLESTEROL	causes	phenotype	0.65
MICROGLIA	associated_with	cell_type	0.65
CHOLESTEROL	implicated_in	phenotype	0.60

Targeting Hypotheses (13)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.801	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.779	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Oligodendrocyte Precursor Cell Senescence in White Matter Di	0.769	-	Senescent cell clearance as neurodegener
Metabolic Checkpoint Failure in NG2+ Oligodendrocyte Progeni	0.680	neurodegeneration	-
White Matter Oligodendrocyte Protection via CXCL10 Inhibitio	0.675	neurodegeneration	Gene expression changes in aging mouse b

White Matter Vulnerability Prevention via Oligodendrocyte Pr	0.667	neurodegeneration	Gene expression changes in aging mouse b
Oligodendrocyte White Matter Vulnerability	0.651	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling	0.649	neurodegeneration	Gene expression changes in aging mouse b
White Matter Immune Checkpoint Restoration	0.644	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Oligodendrocyte-Microglia Cross-talk in White	0.600	neurodegeneration	Gene expression changes in aging mouse b
OPC differentiation blockade contributes to white matter deg	0.599	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
TREM2-Mediated Oligodendrocyte-Microglia Signaling in White	0.587	neurodegeneration	Gene expression changes in aging mouse b
TREM2-Mediated Oligodendrocyte Metabolic Support in White Ma	0.380	neurodegeneration	TREM2 in Alzheimer's Disease: Mechanisms

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	mouse models of Alzheimer's di	proposed	N/A
CXCL10 biomarker analysis for CPSP prediction	clinical	chronic postsurgical pain	0.900	human patients undergoing thor	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	human brain tissue	proposed	N/A
E2F coordination of G2/M transcriptional program	exploratory		0.750	endocycling mammalian cells	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular ma [PMID:41053177]	Lin B, Zhou J, Geng D, Chai S, Zhang X e	Cell Death Differ	2026
Unveiling the choroidal immune landscape revealed interferon-gamma and TNF-alpha [PMID:41077603]	Ye L, Zhao T, Tian H, Li R, Li Z et al.	Sci China Life Sci	2026
METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934]	Sun Y, Ren Z, Ge J, Zhang W, Shao F et a	Biochim Biophys Acta Mol Basis	2026
Mitochondrial NAD(+)-mediated mitophagy alleviates type I interferon response to [PMID:41231107]	Lan T, Shang D, Lin L, Wang H, Zou J et	Autophagy	2026
The mechanism of Qing-Fei-Yin decoction against influenza: Synergistical inhibit [PMID:41317805]	Nie W, Wang M, Cheng M, Ren Z, Liu G et	J Ethnopharmacol	2026
IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095]	Peng M, Shu D, Chen Z, Yang Z, Zhang M e	J Neuroinflammation	2026
Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814]	Zhang X, Xue J, Zhao C, Zeng C, Zhong J	J Clin Invest	2026
Overlapping autoimmunity and demyelination syndromes associated with TNF inhibit [PMID:41652144]	Daood R, Naffaa ME, Azrilin O, Hassan F,	Clin Rheumatol	2026
Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028]	Yu D, Kang J, Jiang W, Zhang C, Zhao X e	Neuropharmacology	2026
Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614]	Li Z, Tan B, Dong K, Yu X, Zhang SW et a	Biochem Pharmacol	2026
Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873]	Main BS, Villapol S, Buenaventura RG, Ha	Brain Behav Immun	2026
Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781]	Bruna-Jara B, More J, Lobos P, Ponce DP,	Scientific reports	2026
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting [PMID:41799958]	Wu W, Cheng Z, Shi P, Gao H, Chen X et a	Bioact Mater	2026
Immune checkpoint inhibitor-associated inflammatory arthritis. [PMID:41800958]	Kim ST, Bass AR	Arthritis Rheumatol	2026
Genetic Variation in the Chemokine Network and Atherosclerosis Risk. [PMID:41824188]	Zangas P, Georgakis MK	Curr Atheroscler Rep	2026
Pathogenic mechanisms of action of autoantibody-mediated central nervous system [PMID:41831629]	Lerch M, Irani SR, Ramanathan S	Autoimmun Rev	2026
Chemokine-defined macrophage niches establish spatial organization of tumor immu [PMID:41872505]	Ghosh S, Li X, Rawat K, Dighal A, Kalino	Nat Immunol	2026
TRUE-MOGAD Score: A Novel Scoring System to Identify MOGAD Among Positive MOG-Ig [PMID:41921125]	Vilaseca A, Filippatou AG, Said Y, Sechi	Neurol Neuroimmunol Neuroinfla	2026
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. [PMID:41925507]	Flanagan EP, Hemingway C	Continuum (Minneap Minn)	2026
Therapeutic updates in NMOSD and MOGAD: From present practice to future promise. [PMID:41927387]	Elosua-Bayés I, Cobo-Calvo A	Rev Neurol (Paris)	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WHITE MATTER in their description or question text

WHITE MATTER

Understanding Entity Pages

Summary

Pathway Diagram

Outgoing (116)

Incoming (488)

Targeting Hypotheses (13)

Mentioning Analyses (0)

Experiments (4)

Related Papers (20)

Debates (0)

Related Research

White Matter Vulnerability Prevention via Oligodendrocyte Protection

Oligodendrocyte White Matter Vulnerability

TREM2-Mediated Oligodendrocyte-Microglia Metabolic Coupling in White Matter Neur

White Matter Immune Checkpoint Restoration

TREM2-Mediated Oligodendrocyte-Microglia Cross-talk in White Matter Neurodegener

OPC differentiation blockade contributes to white matter degeneration in early-s

TREM2-Mediated Oligodendrocyte-Microglia Signaling in White Matter Neurodegenera

TREM2-Mediated Oligodendrocyte Metabolic Support in White Matter Neurodegenerati