concept

FIBROBLASTS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FIBROBLASTS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

367Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	FIBROBLASTS
Key Genes/Proteins	AKT, ALS4, ALZHEIMER, AMPK, AMYLOID, APOE
Related Diseases	aging, ALS, ALZHEIMER'S DISEASE
Related Pathways	AMPK PATHWAY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Meningeal Fibroblasts

cell · 2289 words

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Pathway Diagram

graph TD
    FIBROBLASTS["FIBROBLASTS"]
    FIBROBLASTS -->|"activates"| FIBROSIS["FIBROSIS"]
    FIBROBLASTS -->|"activates"| STEM_CELLS["STEM CELLS"]
    FIBROBLASTS -->|"activates"| IPSC["IPSC"]
    FIBROBLASTS -->|"involved_in"| Wound_Healing["Wound Healing"]
    FIBROBLASTS -->|"contributes to"| Scar_Deposition["Scar Deposition"]
    FIBROBLASTS -->|"expressed in"| miR_3960["miR-3960"]
    FIBROBLASTS -->|"product_of"| Exosomes["Exosomes"]
    FIBROBLASTS -->|"activates"| NEURON["NEURON"]
    CANCER["CANCER"] -->|"interacts"| FIBROBLASTS
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| FIBROBLASTS
    Adaptive_Immune_Cells["Adaptive Immune Cells"] -->|"modulates"| FIBROBLASTS
    SOD1["SOD1"] -->|"regulates"| FIBROBLASTS
    SMC["SMC"] -->|"activates"| FIBROBLASTS
    BDNF["BDNF"] -->|"activates"| FIBROBLASTS

Outgoing (131)

Target	Relation	Type	Str
STEM CELLS	activates	cell_type	0.95
FIBROSIS	activates	disease	0.95
IPSC	activates	cell_type	0.95
Scar Deposition	contributes_to	process	0.90
Wound Healing	involved_in	process	0.90
Wound Healing	contributes_to	process	0.90
Exosomes	product_of	organelle	0.85
miR-3960	expressed_in	biomarker	0.85
Innate Immune Response	mediates	process	0.80
Adaptive Immune Response	mediates	process	0.80
NEURON	activates	cell_type	0.80
Skin Aging	contributes_to	biological_process	0.70
NEURAL STEM CELLS	activates	cell_type	0.65
TUMOR GROWTH	exacerbates	phenotype	0.65
ALS	produces	disease	0.65
CELL SURVIVAL	regulates	phenotype	0.65
STING	causes	gene	0.65
PI3K/AKT/MTOR	inhibits	pathway	0.65
MACROPHAGES	interacts_with	cell_type	0.65
INFLAMMATION	regulates	process	0.65
NICOTINAMIDE	associated_with	drug	0.65
IMMUNE RESPONSE	activates	phenotype	0.65
CHOLESTEROL	interacts_with	phenotype	0.65
AMPK PATHWAY	regulates	pathway	0.65
TUMOR CELLS	interacts_with	cell_type	0.65
miR_3960	activates	gene	0.64
MITOPHAGY	treats	phenotype	0.60
LEUKEMIA_CELLS	activates	cell_type	0.56
GEMCITABINE	associated_with	drug	0.55
MOTOR NEURONS	activates	cell_type	0.50
MACROPHAGES	activates	cell_type	0.50
NEUTROPHILS	associated_with	concept	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
PARKINSON'S DISEASE	activates	disease	0.50
RAPAMYCIN	associated_with	drug	0.50
PERICYTES	interacts_with	cell_type	0.50
T CELLS	interacts_with	cell_type	0.50
SENESCENCE	regulates	process	0.50
ROS	regulates	protein	0.50
NEURON	interacts_with	cell_type	0.50
FIBROSIS	regulates	disease	0.50
PULMONARY FIBROSIS	activates	disease	0.50
MTOR	activates	gene	0.50
PI3K	activates	gene	0.50
B CELLS	associated_with	concept	0.50
CELL MIGRATION	activates	concept	0.50
B CELLS	activates	concept	0.50
RESVERATROL	associated_with	concept	0.50
EXTRACELLULAR MATRIX	interacts_with	concept	0.50
CHRONIC INFLAMMATION	interacts_with	concept	0.50

Incoming (236)

Source	Relation	Type	Str
CANCER	interacts_with	disease	0.95
AUTOPHAGY	activates	process	0.95
CANCER	activates	disease	0.80
AUTOPHAGY	regulates	process	0.80
Adaptive Immune Cells	modulates	cell_type	0.80
Metformin	targets	drug	0.75
TNF	activates	gene	0.70
NEURONS	associated_with	cell_type	0.65
ULK1	causes	gene	0.65
METFORMIN	treats	drug	0.65
SNAP25	inhibits	gene	0.65
C9orf72	causes	gene	0.65
CANCER	causes	disease	0.65
PDGF	activates	gene	0.65
ASTROCYTES	produces	cell_type	0.65
MYC	activates	gene	0.65
AUTOPHAGOSOMES	regulates	organelle	0.65
AUTOPHAGOSOMES	activates	organelle	0.65
C9orf72	transports	gene	0.65
ULK1	phosphorylates	gene	0.65
SOD1	regulates	gene	0.64
SMC	activates	cell_type	0.64
TH	synergizes_with	gene	0.60
AUTOPHAGOSOMES	expressed_in	organelle	0.55
TAU	expressed_in	protein	0.55
RIPK1	activates	gene	0.50
TAX1BP1	activates	gene	0.50
Necroptosis	activates	pathway	0.50
inflammation	interacts_with	pathway	0.50
aging	interacts_with	phenotype	0.50
Reactive Oxygen Species	interacts_with	process	0.50
inflammation	activates	pathway	0.50
inflammation	associated_with	pathway	0.50
SLC16A2	associated_with	concept	0.50
MIRO1	regulates	protein	0.50
MIRO1	associated_with	protein	0.50
RHOT1	activates	gene	0.50
MIRO1	activates	protein	0.50
PARKINSON	activates	gene	0.50
Parkinson's Disease	activates	disease	0.50
disease	activates	disease	0.50
PARKINSON'S	activates	concept	0.50
STEM CELLS	activates	concept	0.50
GAIN	associated_with	gene	0.50
STAT3	activates	gene	0.50
Pancreatic Cancer	activates	disease	0.50
FIBROSIS	interacts_with	disease	0.50
CARCINOMA	interacts_with	disease	0.50
Cirrhosis	interacts_with	disease	0.50
HEPATOCELLULAR CARCINOMA	interacts_with	disease	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1	0.492	neurodegeneration	How do perivascular cells specifically r
RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upre	0.442	neurodegeneration	How do perivascular cells specifically r

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FIBROBLASTS in their description or question text

No additional research found