gene

TLR2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TLR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

685Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

TLR2 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 284 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TLR2
Full Name	Toll-Like Receptor 2
Chromosome	4q31.3
Protein Type	Receptor
Function	TLR2 is expressed in microglia, astrocytes, and neurons throughout the brain.
Primary Expression	microglia, astrocytes, and neurons throughout the brain
Amino Acids	784 aa
Exons	3
Pathways	NF-κB, PI3K
UniProt ID	Q9Y257
NCBI Gene ID	7103
Ensembl ID	ENSG00000137462
OMIM	603028
GeneCards	TLR2
Human Protein Atlas	TLR2
Associated Diseases	Als, Alzheimer, Brain Injury, Fibrosis, HYPOXIC-ISCHEMIC ENCEPHALOPATHY
Known Drugs/Compounds	C29
Interactions	AKT, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND
KG Connections	685 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TLR2 — AlphaFold Q9Y257 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TLR2 — Toll-Like Receptor 2

gene · 884 words

→

TLR2 Protein — Toll-Like Receptor 2

protein · 653 words

→

Pathway Diagram

flowchart TD
    TLR2["TLR2
Toll-like Receptor 2"]
    TRAF6["TRAF6
TNF Receptor
Associated Factor 6"]
    NFKB["NF-kappaB
Nuclear Factor
Kappa B"]
    IRF3["IRF3
Interferon
Regulatory Factor 3"]
    STING1["STING1
Stimulator of
Interferon Genes"]
    
    ALPHA_SYN["alpha-synuclein
Protein Aggregation"]
    AUTOPHAGY["Autophagy
Cellular Clearance
Mechanism"]
    C3["C3
Complement
Component"]
    
    NEUROINFLAM["Neuroinflammation
CNS Immune
Activation"]
    PARKINSON["Parkinson's Disease
Motor Neuron
Degeneration"]
    ALZHEIMER["Alzheimer's Disease
Cognitive
Decline"]
    ALS["ALS
Motor Neuron
Disease"]
    MS["Multiple Sclerosis
Demyelinating
Disease"]
    NEURODEGENERATION["Neurodegeneration
Progressive
Cell Death"]
    
    TLR2 -->|"associates with"| TRAF6
    TRAF6 -->|"activates"| NFKB
    TLR2 -->|"activates"| NFKB
    TLR2 -->|"inhibits"| IRF3
    TLR2 -->|"modulates"| STING1
    TLR2 -->|"regulates"| C3
    
    TLR2 -->|"promotes"| ALPHA_SYN
    TLR2 -->|"inhibits"| AUTOPHAGY
    
    NFKB -->|"drives"| NEUROINFLAM
    NEUROINFLAM -->|"leads to"| NEURODEGENERATION
    ALPHA_SYN -->|"contributes to"| PARKINSON
    
    TLR2 -->|"activates"| NEUROINFLAM
    TLR2 -->|"associated with"| PARKINSON
    TLR2 -->|"regulates"| ALZHEIMER
    TLR2 -->|"activates"| ALS
    TLR2 -->|"activates"| MS
    
    NEURODEGENERATION -->|"manifests as"| PARKINSON
    NEURODEGENERATION -->|"manifests as"| ALZHEIMER
    NEURODEGENERATION -->|"manifests as"| ALS
    NEURODEGENERATION -->|"manifests as"| MS
    
    style TLR2 fill:#006494
    style AUTOPHAGY fill:#1b5e20
    style IRF3 fill:#4a1a6b
    style TRAF6 fill:#4a1a6b
    style STING1 fill:#4a1a6b
    style C3 fill:#4a1a6b
    style NFKB fill:#ef5350
    style NEUROINFLAM fill:#ef5350
    style ALPHA_SYN fill:#ef5350
    style PARKINSON fill:#5d4400
    style ALZHEIMER fill:#5d4400
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style NEURODEGENERATION fill:#5d4400

Outgoing (406)

Target	Relation	Type	Str
Nlrp3 Inflammasome	activates	protein	0.95
NLRP3	activates	gene	0.95
Pyroptosis	promotes	process	0.92
Neonatal Hypoxic-Ischemic Brain Injury	therapeutic_target	disease	0.92
GSDMD	upregulates	gene	0.90
inflammatory cytokine production	activates	mechanism	0.90
tau aggregates	recognizes	mechanism	0.90
STING1	regulates	protein	0.90
Brain Injury	causes	phenotype	0.88
Neuronal Apoptosis	promotes	process	0.88
brain injury	drives	phenotype	0.88
rosacea	associated_with	disease	0.85
neuronal apoptosis	promotes	process	0.85
IBA1	upregulates	gene	0.82
NF-κB	activates	protein	0.80
IRF3	inhibits	protein	0.80
TRAF6	associated_with	protein	0.80
cytokines	produces	process	0.80
HYPOXIC-ISCHEMIC ENCEPHALOPATHY	associated_with	disease	0.80
Parkinson	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
Inflammation	activates	disease	0.75
MTOR	associated_with	protein	0.75
IMMUNE RESPONSE	mediates	pathway	0.75
Parkinson's disease	associated_with	disease	0.70
Toll-Like Receptor	activates	pathway	0.70
autophagy	inhibits	process	0.70
α-synuclein	activates	protein	0.70
Nf-Κb	activates	pathway	0.70
Nf-Κb	inhibits	pathway	0.70
PARKINSON'S DISEASE	activates	gene	0.70
PARKINSON	activates	gene	0.70
Apoptosis	activates	pathway	0.70
NF-ΚB	inhibits	gene	0.70
NEURON	activates	gene	0.70
Toll-Like Receptor	regulates	pathway	0.70
Als	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Type 2 Diabetes	regulates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Neuroinflammation	inhibits	disease	0.65

Incoming (279)

Source	Relation	Type	Str
genes-tlr2	linked_to	wiki	1.00
C29	inhibits	drug	0.95
Cyclosporine A	downregulates	drug	0.92
hypoxic-ischemic injury	upregulates	process	0.88
ALZHEIMER'S DISEASE	associated_with	disease	0.82
APOPTOSIS	associated_with	gene	0.82
LL37	interacts_with	protein	0.80
APOPTOSIS	activates	gene	0.80
MICROGLIA	associated_with	cell_type	0.74
AMYLOID	associated_with	protein	0.74
NF-ΚB	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
MTOR	associated_with	gene	0.66
IL-1B	associated_with	gene	0.66
HSP60	causes	gene	0.60
HMGB1	activates	gene	0.60
NLRP3	activates	gene	0.60
GSDMD	activates	gene	0.60
NLRP3	regulates	gene	0.60
TLR	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-6	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NF-ΚB	inhibits	gene	0.60
RAGE	regulates	gene	0.60
CBL	inhibits	gene	0.60
MAPK1	expressed_in	gene	0.60
S100A9	expressed_in	gene	0.60
C3	expressed_in	gene	0.60
JUN	interacts_with	gene	0.60
IL1B	regulates	gene	0.60
CD14	associated_with	gene	0.60
CMKLR1	regulates	gene	0.60
BAX	inhibits	gene	0.60
PSME3	associated_with	gene	0.60
IL-17	associated_with	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
HUB GENES	regulates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
CCL2	associated_with	gene	0.60
CMPK2	activates	gene	0.60
JUN	activates	gene	0.60
PI3K	regulates	gene	0.60
AIFM1	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
TREM2	expressed_in	gene	0.60
LRP1	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TLR2 Recognition of Gut-Derived Fungal and Bacterial D-Alany	0.550	neurodegeneration	How does gut microbiome dysbiosis contri
Cross-Seeding: Gut Microbiome-Derived Bacterial Curli and Fu	0.540	neurodegeneration	How does gut microbiome dysbiosis contri

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

neurodegeneration | 2026-04-15 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract shows that Gal3 binding to pTau greatly enhances tau fibrillation,

closed · Rounds: 4 · Score: 0.92 · 2026-04-16

Related Research

Hypotheses and analyses mentioning TLR2 in their description or question text

No additional research found