gene

BID

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BID: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

353Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Pro-apoptotic BCL2 family protein linking extrinsic and intrinsic apoptosis pathways in neurodegeneration

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🧬 Gene Info

Gene Symbol	BID
Full Name	BH3 Interacting Domain Death Agonist
Chromosome	22q11.21
Protein Family	BCL2 family, BH3-only proteins
Function	is a relatively inactive cytosolic protein.
Molecular Weight	22 kDa
Amino Acids	195 aa
Pathways	Apoptosis, Stem Cell
UniProt ID	P55957
NCBI Gene ID	637
Ensembl ID	ENSG00000105619
OMIM	603678
GeneCards	BID
Human Protein Atlas	BID
N-terminal region	Contains caspase-8 cleavage sites (D75, D81)
Associated Diseases	Aging, Als, Alzheimer, Inflammation, Neurodegeneration
Interactions	AKT, AND, APOPTOSIS, AUTOPHAGY, BAD, BAX
KG Connections	351 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BID — AlphaFold P55957 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BID — BH3 Interacting Domain Death Agonist

gene · 1168 words

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BID Protein

protein · 621 words

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Pathway Diagram

graph TD
    BID["BID"]
    BID -->|"target for"| Parkinson["Parkinson"]
    BID -->|"target for"| Inflammation["Inflammation"]
    BID -->|"activates"| Tumor["Tumor"]
    BID -->|"activates"| Als["Als"]
    BID -->|"target for"| Neurodegeneration["Neurodegeneration"]
    BID -->|"target for"| Aging["Aging"]
    BID -->|"target for"| Alzheimer["Alzheimer"]
    IFN__["IFN-gamma"] -->|"contributes to"| BID
    IFN_gamma["IFN-gamma"] -->|"contributes to"| BID
    TLR2["TLR2"] -->|"target for"| BID
    MTOR["MTOR"] -->|"target for"| BID
    PLA2G6["PLA2G6"] -->|"target for"| BID
    PANK2["PANK2"] -->|"target for"| BID
    MAX["MAX"] -->|"target for"| BID
    GENES["GENES"] -->|"target for"| BID
    ERK["ERK"] -->|"target for"| BID
    BAX["BAX"] -->|"activates"| BID

Outgoing (246)

Target	Relation	Type	Str
Oxidative Stress	mediates	process	0.90
apoptosis	mediates	process	0.85
Apoptosis	associated_with	process	0.80
Mitochondria	participates_in	entity	0.80
Tumor	activates	disease	0.75
Als	regulates	disease	0.75
Apoptosis	activates	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
Tumor	causes	disease	0.65
Frontotemporal Dementia	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	causes	disease	0.65
Frontotemporal Dementia	encodes	disease	0.65
Neurodegeneration	causes	disease	0.65
Cancer	activates	disease	0.65
Aging	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Melanoma	activates	disease	0.65
Ataxia	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	causes	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Dementia	encodes	disease	0.65
Amyotrophic Lateral Sclerosis	encodes	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	encodes	disease	0.65
Aging	therapeutic_target	disease	0.65
Spinal Muscular Atrophy	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Ferroptosis	expressed_in	disease	0.65
Als	causes	disease	0.65
Als	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Aging	encodes	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
OXIDATIVE_STRESS	causes	phenotype	0.64
ERK	causes	gene	0.60
PSME3	associated_with	gene	0.60
Apoptosis	expressed_in	pathway	0.60
APOPTOSIS	expressed_in	gene	0.60
Er Stress	expressed_in	pathway	0.60
Cell Cycle	expressed_in	pathway	0.60

Incoming (107)

Source	Relation	Type	Str
IFN-γ	contributes_to	protein	0.80
IFN-gamma	contributes_to	protein	0.80
BCL-2	interacts_with	gene	0.70
APOPTOSIS	activates	gene	0.70
BAX	activates	gene	0.70
BAX	interacts_with	gene	0.70
PLIN4	encodes	gene	0.60
HNRNPA2B1	encodes	gene	0.60
ATXN2	encodes	gene	0.60
HNRNPA1	encodes	gene	0.60
CNTN4	encodes	gene	0.60
SMN	encodes	gene	0.60
CCNF	encodes	gene	0.60
TBC1D24	encodes	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
NEURODEGENERATION	causes	gene	0.60
RAS	causes	gene	0.60
ERK	causes	gene	0.60
JAK	causes	gene	0.60
AMYLOID	causes	gene	0.60
IL-17	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
IL-1	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
BAK1	associated_with	gene	0.60
BAX	associated_with	gene	0.60
TAU	therapeutic_target	gene	0.60
BAD	degrades	entity	0.60
FUS	encodes	gene	0.60
PYROPTOSIS	causes	gene	0.60
MTOR	activates	gene	0.60
BAD	associated_with	gene	0.60
MTCH2	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
BCL2 FAMILY	regulates	gene	0.60
PLA2G6	therapeutic_target	gene	0.60
PANK2	therapeutic_target	gene	0.60
MAX	therapeutic_target	gene	0.60
PTEN	activates	gene	0.60
ATXN2	expressed_in	gene	0.60
HNRNPA1	expressed_in	gene	0.60
CNTN4	expressed_in	gene	0.60
PLIN4	expressed_in	gene	0.60
JNK	causes	gene	0.60
AKT	causes	gene	0.60
BCL2	regulates	gene	0.60
MDM2	associated_with	gene	0.60
BAX	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Drp1-S616 Phosphorylation Fission Priming Enables t-Bid-Driv	0.693	neurodegeneration	What upstream mechanisms cause TDP-43 to

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BID in their description or question text

No additional research found