concept

NMDAR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NMDAR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

104Connections

2Hypotheses

0Analyses

46Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	NMDAR
Key Genes/Proteins	ABETA, AKT, APOE, APOE4, APP, ASC
Related Diseases	ALZHEIMER, Alzheimer's disease, ALZHEIMER'S DISEASE
Related Pathways	apoptosis pathway, autophagy pathway
Linked Hypotheses	2 hypotheses

Pathway Diagram

graph TD
    NMDAR[NMDAR]
    NMDAR -->|mediates| Activity_Dependent_Synaptic_Pl[Activity-Dependent Synaptic Plasticity]
    NMDAR -->|activates| pro_BDNF_Signaling[pro-BDNF Signaling]
    NMDAR -->|expressed in| neurons[neurons]
    NMDAR -.protects against.-> APP[APP]
    NMDAR -->|activates| AKT[AKT]
    NMDAR -->|activates| NEURODEGENERATION[NEURODEGENERATION]
    NMDAR -->|expressed in| SST[SST]
    NMDAR -->|activates| TLR2[TLR2]
    NMDAR -->|activates| TLR4[TLR4]
    EEF2[EEF2] -->|inhibits| NMDAR
    Ketamine[Ketamine] -->|inhibits| NMDAR
    ABETA[ABETA] -->|activates| NMDAR
    APOE[APOE] -->|activates| NMDAR
    SYNAPTIC_PLASTICITY[SYNAPTIC PLASTICITY] -->|activates| NMDAR
    MEMANTINE[MEMANTINE] -->|inhibits| NMDAR
    SST_INs[SST-INs] -->|expressed in| NMDAR

Outgoing (46)

Target	Relation	Type	Str
Activity-Dependent Synaptic Plasticity	mediates	process	0.85
pro-BDNF Signaling	activates	pathway	0.80
Alzheimer's disease	associated_with	disease	0.70
neurons	expressed_in	cell_type	0.70
NEURODEGENERATION	activates	phenotype	0.65
APP	protects_against	gene	0.65
APP	treats	gene	0.65
AKT	activates	gene	0.65
epigenetic regulation	participates_in	pathway	0.60
Parkinson's disease	interacts_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
synaptic plasticity	participates_in	pathway	0.60
T cells	expressed_in	cell_type	0.60
PINK1	activates	gene	0.60
PARKIN	activates	gene	0.60
blood-brain barrier	participates_in	pathway	0.60
Alzheimer's disease	activates	disease	0.60
MAPK signaling	participates_in	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
RNA	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
SST	expressed_in	gene	0.60
TLR2	activates	gene	0.60
TLR4	activates	gene	0.60
neurodegeneration	interacts_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
schizophrenia	causes	disease	0.60
epilepsy	causes	disease	0.60
glutamate signaling	participates_in	pathway	0.60
stroke	implicated_in	disease	0.60
neurodegeneration	activates	disease	0.60
epilepsy	activates	disease	0.60
PV	expressed_in	gene	0.60
schizophrenia	inhibits	disease	0.60
schizophrenia	associated_with	disease	0.60
NEURODEGENERATION	regulates	phenotype	0.56
PS1	activates	gene	0.55
PSD-95	activates	gene	0.55
PSD-95	associated_with	gene	0.55
neurotrophin signaling	participates_in	pathway	0.55
ALZHEIMER'S DISEASE	implicated_in	disease	0.55
CA1	associated_with	brain_region	0.50
CA3	associated_with	brain_region	0.50

Incoming (58)

Source	Relation	Type	Str
Ketamine	inhibits	drug	0.90
EEF2	inhibits	gene	0.90
ABETA	activates	protein	0.80
SYNAPTIC PLASTICITY	activates	phenotype	0.70
APOE	activates	gene	0.70
APOE	regulates	gene	0.70
MEMANTINE	treats	drug	0.65
MEMANTINE	regulates	drug	0.65
MEMANTINE	inhibits	drug	0.65
IFN	regulates	gene	0.60
ERK	activates	gene	0.60
IFN	activates	gene	0.60
LAMP2B	interacts_with	gene	0.60
NLR	activates	gene	0.60
MAPK	activates	gene	0.60
ASK1	activates	gene	0.60
EAAT2	activates	gene	0.60
NMDA	causes	gene	0.60
GABA	associated_with	gene	0.60
EAAT2	associated_with	gene	0.60
SST-INs	expressed_in	cell_type	0.60
CYP46A1	protects_against	gene	0.60
CYP46A1	associated_with	gene	0.60
CYP46A1	regulates	gene	0.60
HMGCR	regulates	gene	0.60
CYP46A1	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
AKT	activates	gene	0.60
ASC	activates	gene	0.60
ATF3	activates	gene	0.60
ATG5	activates	gene	0.60
CCR2	activates	gene	0.60
CHOP	activates	gene	0.60
IRAK1	activates	gene	0.60
ISG15	activates	gene	0.60
JNK	activates	gene	0.60
LAMP2	activates	gene	0.60
LC3	activates	gene	0.60
MLKL	activates	gene	0.60
NLRP3	activates	gene	0.60
SYNAPTIC PLASTICITY	implicated_in	phenotype	0.60
MAPK	protects_against	gene	0.60
memantine	targets	drug	0.60
APOE4	regulates	gene	0.60
GRIN2A	associated_with	gene	0.60
CD14	activates	gene	0.60
HDAC1	activates	gene	0.60
APP	regulates	gene	0.60
GDNF	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Fyn-anchored dendritic tau/NMDAR signaling persists after tr	0.670	neurodegeneration	Does tau dendritic missorting persist in
Subtle NMDAR Inhibition Attenuates Excitotoxicity-Driven Tau	0.620	neurodegeneration	Investigate prion-like spreading of tau

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NMDAR in their description or question text

No additional research found