protein 653 words KG: TLR2PROTEIN
Contents

TLR2 Protein — Toll-Like Receptor 2

🔬 Protein Info
Gene SymbolTLR2
Full NameToll-Like Receptor 2
Chromosome4q31.3
Protein TypeReceptor
FunctionTLR2 is expressed in microglia, astrocytes, and neurons throughout the brain.
Primary Expressionmicroglia, astrocytes, and neurons throughout the brain
Amino Acids784 aa
Exons3
PathwaysNF-κB, PI3K
UniProt IDQ9Y257
NCBI Gene ID7103
Ensembl IDENSG00000137462
OMIM603028
GeneCardsTLR2
Human Protein AtlasTLR2
Associated DiseasesAls, Alzheimer, Brain Injury, Fibrosis, HYPOXIC-ISCHEMIC ENCEPHALOPATHY
Known Drugs/CompoundsC29
InteractionsAKT, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND
KG Connections685 knowledge graph edges
DatabasesGeneCardsHPASTRING

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UniProtWikipedia

Related Hypotheses (16)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (10)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (4)

Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90
TLR expression analysis in Parkinson's disease patients
clinical · proposed · Score: 0.85
TLR expression in α-synuclein overexpressing mice
validation · proposed · Score: 0.80
NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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