gene

PPP1CB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP1CB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

111Connections

0Hypotheses

0Analyses

50Outgoing

37Incoming

0Experiments

0Debates

Summary

PPP1CB is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, therapeutic target. Associated with ALS, Als, Cancer. Connected to 47 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PPP1CB
Chromosome	2p23.3
Protein Family	Protein phosphatase type 1 family
Molecular Weight	37 kDa
Pathways	Epigenetic
Ensembl ID	ENSG00000185630
GeneCards	PPP1CB
Human Protein Atlas	PPP1CB
EC Number	3.1.3.16
Structure	Catalytic subunit (~37 kDa)
[Tau protein](/proteins/tau)	Dephosphorylation at multiple AD-relevant sites (Ser202, Thr231, Ser396) [@mandelkow2004]
Glycogen synthase	Regulation of glycogen metabolism
Synaptic proteins	Synapsin, PSD-95, AMPA receptor subunits
Transcription factors	CREB, c-Jun
Tau pathology	PP1-mediated tau dephosphorylation is a key mechanism for reducing tau aggregation and toxicity [@mandelkow2004]
Associated Diseases	Als, Inflammation, Parkinson
Interactions	CANCER, HK2, NSD3, STAT3
KG Connections	111 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPP1CB Gene

gene · 538 words

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Pathway Diagram

graph TD
    PPP1CB["PPP1CB"]
    STAT3["STAT3"]
    PPP1CB -->|"modifies"| STAT3
    Als{"Als"}
    PPP1CB -->|"associated with"| Als
    Parkinson{"Parkinson"}
    PPP1CB -->|"therapeutic target"| Parkinson
    Inflammation{"Inflammation"}
    PPP1CB -->|"therapeutic target"| Inflammation
    Cancer{"Cancer"}
    PPP1CB -->|"inhibits"| Cancer
    Carcinoma{"Carcinoma"}
    PPP1CB -->|"inhibits"| Carcinoma
    ALS{"ALS"}
    PPP1CB -->|"associated with"| ALS
    PPP1CB -->|"associated with"| Parkinson
    PPP1CB -->|"associated with"| Inflammation
    TLR2["TLR2"]
    PPP1CB -->|"therapeutic target"| TLR2
    MTOR["MTOR"]
    PPP1CB -->|"associated with"| MTOR
    BID["BID"]
    PPP1CB -->|"associated with"| BID
    NSD3["NSD3"]
    NSD3 -->|"interacts with"| PPP1CB
    LAMP2["LAMP2"]
    LAMP2 -->|"associated with"| PPP1CB
    TFRC["TFRC"]
    TFRC -->|"associated with"| PPP1CB
    MTOR -->|"associated with"| PPP1CB
    GENES["GENES"]
    GENES -->|"therapeutic target"| PPP1CB
    BID -->|"associated with"| PPP1CB
    BAD["BAD"]
    BAD -->|"associated with"| PPP1CB
    TLR2 -->|"therapeutic target"| PPP1CB
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"associated with"| PPP1CB
    IFN["IFN"]
    IFN -->|"associated with"| PPP1CB
    GENES -->|"associated with"| PPP1CB
    style PPP1CB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (74)

Target	Relation	Type	Str
STAT3	modifies	protein	0.90
Antimicrobial Responses	involved_in	process	0.80
Antimicrobial Response	involved_in	process	0.80
antimicrobial peptide activity	involved_in	process	0.75
Als	associated_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Ferroptosis	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Immune Response	associated_with	pathway	0.60
PSME3	expressed_in	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
IL-1	therapeutic_target	gene	0.60
Autophagy	expressed_in	pathway	0.60
Mtor	expressed_in	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
MTOR	expressed_in	gene	0.60
Cytokine	therapeutic_target	protein	0.60
Il-17	therapeutic_target	protein	0.60
PARKINSON	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
Epigenetic	regulates	pathway	0.60
Glycolysis	inhibits	pathway	0.60
IFN-Γ	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
IFN	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
TFRC	degrades	entity	0.60
ferroptosis	participates_in	pathway	0.60
ferroptosis	associated_with	process	0.60
Ferroptosis	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Apoptosis	associated_with	pathway	0.60
STAT3	inhibits	gene	0.60
TLR2	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
IL-17	associated_with	gene	0.60
IFN-Γ	associated_with	gene	0.60

Incoming (37)

Source	Relation	Type	Str
NSD3	interacts_with	protein	0.90
LAMP2	associated_with	gene	0.60
TFRC	associated_with	gene	0.60
BID	expressed_in	gene	0.60
IL-17	associated_with	gene	0.60
BID	associated_with	gene	0.60
BAD	associated_with	gene	0.60
TLR2	therapeutic_target	gene	0.60
BAD	degrades	entity	0.60
BID	degrades	entity	0.60
LAMP2	degrades	entity	0.60
MTOR	degrades	entity	0.60
MTOR	associated_with	gene	0.60
PSME3	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
IL-1	therapeutic_target	gene	0.60
IL-17	therapeutic_target	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
BMPR1A	expressed_in	gene	0.60
GENES	therapeutic_target	gene	0.60
APOPTOSIS	associated_with	gene	0.60
IFN	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AUTOPHAGY	co_discussed	gene	0.50
GENES	co_discussed	gene	0.50
IFN-Γ	co_discussed	protein	0.50
IL-1Β	co_discussed	protein	0.50
PARKINSON	co_discussed	gene	0.50
BAD	co_discussed	gene	0.50
BID	co_discussed	gene	0.50
LAMP2	co_discussed	protein	0.50
MTOR	co_discussed	gene	0.50
PARKIN	co_discussed	gene	0.50
mTOR	expressed_in	entity	0.50
Autophagy	expressed_in	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP1CB in their description or question text

No additional research found