gene

CCR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

109Connections

0Hypotheses

0Analyses

50Outgoing

35Incoming

0Experiments

0Debates

Summary

C-C Chemokine Receptor Type 1 - a GPCR for CCL3, CCL5, CCL7, CCL14 involved in neuroinflammation, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and ALS

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🧬 Gene Info

Gene Symbol	CCR1
Full Name	C-C Chemokine Receptor Type 1
Chromosome	3p21.31
Protein Family	Chemokine receptors (GPCR family)
Protein Type	Receptor
Function	encodes a G protein-coupled receptor that binds multiple CC chemokines including CCL3 (MIP-1α), CCL5 (RANTES), CCL7 (MCP-3), CCL14 (HCC-1), and CCL15 (HCC-2).
Amino Acids	355 aa
Exons	5
Pathways	NF-κB
UniProt ID	P32246
NCBI Gene ID	1230
Ensembl ID	ENSG00000163631
OMIM	601626
GeneCards	CCR1
Human Protein Atlas	CCR1
Associated Diseases	Alzheimer's disease, Parkinson's disease, Multiple sclerosis, ALS
Interactions	AND, CCL2, CCL3, CCL5, CCR5, CXCL10
KG Connections	109 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CCR1 — AlphaFold P32246 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CCR1

gene · 1919 words

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Pathway Diagram

graph TD
    CCR1["CCR1"]
    Heart_Failure{"Heart Failure"}
    CCR1 -->|"regulates"| Heart_Failure
    Als{"Als"}
    CCR1 -->|"regulates"| Als
    Hepatitis{"Hepatitis"}
    CCR1 -->|"regulates"| Hepatitis
    Cardiac{"Cardiac"}
    CCR1 -->|"regulates"| Cardiac
    MRC1["MRC1"]
    CCR1 -->|"regulates"| MRC1
    C1QB["C1QB"]
    CCR1 -->|"regulates"| C1QB
    CD38["CD38"]
    CCR1 -->|"regulates"| CD38
    CD163["CD163"]
    CCR1 -->|"regulates"| CD163
    CXCL10["CXCL10"]
    CCR1 -->|"regulates"| CXCL10
    Immune_Response(["Immune Response"])
    CCR1 -->|"regulates"| Immune_Response
    neurodegeneration["neurodegeneration"]
    CCR1 -->|"implicated in"| neurodegeneration
    style CCR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (74)

Target	Relation	Type	Str
Cardiac	regulates	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
Autoimmune	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Als	regulates	disease	0.65
Hepatitis	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
Microglia	inhibits	cell_type	0.60
Macrophage	inhibits	cell_type	0.60
Complement	inhibits	pathway	0.60
Myelination	inhibits	pathway	0.60
Neuroinflammatory	inhibits	pathway	0.60
Tgf-Β	inhibits	pathway	0.60
CXCR3	expressed_in	gene	0.60
Immune Response	regulates	pathway	0.60
CCL2	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
Nf-Κb	inhibits	pathway	0.60
Monocyte	inhibits	cell_type	0.60
CCR5	expressed_in	gene	0.60
CXCL10	expressed_in	gene	0.60
MRC1	regulates	gene	0.60
C1QB	regulates	gene	0.60
CD38	regulates	gene	0.60
CD163	regulates	gene	0.60
CXCL10	regulates	gene	0.60
Immune Response	associated_with	pathway	0.60
Macrophage	associated_with	cell_type	0.60
Cytokine	inhibits	protein	0.60
complement cascade	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
CXCR3	inhibits	gene	0.60
CCR5	inhibits	gene	0.60
CCL3	inhibits	gene	0.60
HDAC3	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
CXCL10	inhibits	gene	0.60
App	associated_with	protein	0.60
JAK-STAT signaling	participates_in	pathway	0.60
Wnt signaling	participates_in	pathway	0.60
CD86	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
IL10	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
IL6	associated_with	gene	0.60

Incoming (35)

Source	Relation	Type	Str
CCL5	activates	gene	0.60
CCL5	expressed_in	gene	0.60
CCL5	interacts_with	gene	0.60
CCL3	activates	gene	0.60
MICROGLIA	inhibits	gene	0.60
CCL3	inhibits	gene	0.60
TNF	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
CCR5	inhibits	gene	0.60
HDAC3	inhibits	gene	0.60
CXCR3	inhibits	gene	0.60
CXCL10	inhibits	gene	0.60
CCL3	expressed_in	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
CCL2	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
AND	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
CYBB	associated_with	gene	0.60
CD163	associated_with	gene	0.60
CSF1R	associated_with	gene	0.60
CD4	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
AIF1	associated_with	gene	0.60
C1QB	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
CCL2	expressed_in	gene	0.60
CCL2	associated_with	gene	0.60
C1QA	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CCR1 in their description or question text

No additional research found